Výsledky vyhledávání - "Adam Stirling"

Patient-reported Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Harboring DNA Damage Response Alterations Treated with Talazoparib: Results from TALAPRO-1

Autor: Fred Saad, Johann de Bono, Philippe Barthélémy, Tanya Dorff, Niven Mehra, Giorgio Scagliotti, Adam Stirling, Jean-Pascal Machiels, Vincent Renard, Marco Maruzzo, Celestia S. Higano, Howard Gurney, Cynthia Healy, Helen Bhattacharyya, Bhakti Arondekar, Alexander Niyazov, Karim Fizazi

Publikováno v: European Urology, 83, 352-360
European Urology, 83, 4, pp. 352-360
European urology, Vol. 83, no. 4, p. 352-360 (2023)

Contains fulltext : 290894.pdf (Publisher’s version ) (Open Access) BACKGROUND: Talazoparib has shown antitumor activity with a manageable safety profile in men with metastatic castration-resistant prostate cancer (mCRPC) and DNA damage response (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163988fbbcdcaa12a4cdf0961aa4b196
https://doi.org/10.1016/j.eururo.2022.05.030

Zobrazit plný text záznamu

Prehospital Pericardiocentesis Using a Pneumothorax Needle

Autor: Kelsey Vanderbosch, Nicholas S Simpson, Aaron E Robinson, Adam Stirling, Gregg A Jones, Paul C. Nystrom

Publikováno v: Prehospital Emergency Care. 26:406-409

Case: We discuss a patient with a penetrating knife wound to the chest who lost pulses from cardiac tamponade. Prehospital ultrasound was able to quickly identify the tamponade and a pericardiocentesis was performed using a Simplified Pneumothorax Em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42671ca91ff3366171bdca706a80e717
https://doi.org/10.1080/10903127.2021.1977441

Zobrazit plný text záznamu

Talazoparib, a Poly(ADP-ribose) Polymerase Inhibitor, for Metastatic Castration-resistant Prostate Cancer and DNA Damage Response Alterations: TALAPRO-1 Safety Analyses

Autor: Niven Mehra, Karim Fizazi, Johann S de Bono, Philippe Barthélémy, Tanya Dorff, Adam Stirling, Jean-Pascal Machiels, Davide Bimbatti, Deepak Kilari, Herlinde Dumez, Consuelo Buttigliero, Inge M van Oort, Elena Castro, Hsiang-Chun Chen, Nicola Di Santo, Liza DeAnnuntis, Cynthia G Healy, Giorgio V Scagliotti

Publikováno v: Oncologist, 27, 10, pp. e783-e795
Oncologist, 27, e783-e795
The oncologist, Vol. 27, no.10, p. e783-e795 (2022)

Background The phase II TALAPRO-1 study (NCT03148795) demonstrated durable antitumor activity in men with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC). Here, we detail the safety profile of talazoparib. Patients and Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5bbcc94516b0548cfb5b8ae5bada51
https://repository.ubn.ru.nl/handle/2066/282353

Zobrazit plný text záznamu

Abstract CT031: TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)– Exploration of genomic loss of heterozygosity (gLOH) and potential associations with antitumor activity

Autor: Johann S. de Bono, Niven Mehra, A. Douglas Laird, Elena Castro, Philippe Barthelemy, Remy Delva, Giorgio V. Scagliotti, Marco Maruzzo, Adam Stirling, Jean-Pascal Machiels, Herlinde Dumez, Vincent Renard, Julia F. Hopkins, Lee A. Albacker, Hsiang-Chun Chen, Cynthia G. Healy, Jijumon Chelliserry, Tanya Dorff, Karim Fizazi

Publikováno v: Cancer Research. 82:CT031-CT031

Background: TALAPRO-1 enrolled men with progressive mCRPC, measurable soft-tissue disease, and tumor DDRm involved directly or indirectly in homologous recombination repair (HRR) (11 gene panel). Men had received 1-2 taxane-based chemotherapy regimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f80df33da798bdec67000a46209f6a6c
https://doi.org/10.1158/1538-7445.am2022-ct031

Zobrazit plný text záznamu

TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)—Exploration of germline DDR alteration landscape and potential associations with antitumor activity

Autor: Tanya B. Dorff, Karim Fizazi, Douglas Laird, Philippe Barthélémy, Remy Delva, Marco Maruzzo, Adam Stirling, Jean-Pascal H. Machiels, Herlinde Dumez, Vincent Renard, Julia Hopkins, Lee A. Albacker, Hsiang-Chun Chen, Cynthia G. Healy, Jijumon Chelliserry, Inge M. van Oort, Giorgio V. Scagliotti, Johann S. De Bono, Niven Mehra

Publikováno v: Journal of Clinical Oncology. 40:157-157

157 Background: TALAPRO-1 enrolled men with progressive mCRPC with measurable soft-tissue disease and tumor DDRm involved directly or indirectly in homologous recombination repair (HRR) (11 gene panel). These men had received 1–2 taxane chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11f2229059c093ee7e21a908db18a244
https://doi.org/10.1200/jco.2022.40.6_suppl.157

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání