Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam Spong"'
Autor:
Liou Y Sun, Adam Spong, William R Swindell, Yimin Fang, Cristal Hill, Joshua A Huber, Jacob D Boehm, Reyhan Westbrook, Roberto Salvatori, Andrzej Bartke
Publikováno v:
eLife, Vol 2 (2013)
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of gene
Externí odkaz:
https://doaj.org/article/4ce78ac1ab71494b8bc7fc2a1bcca3f1
Autor:
Michael S Bonkowski, Fernando P Dominici, Oge Arum, Juliana S Rocha, Khalid A Al Regaiey, Reyhan Westbrook, Adam Spong, Jacob Panici, Michal M Masternak, John J Kopchick, Andrzej Bartke
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4567 (2009)
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or insulin signaling. Calorie restriction (CR) is the only intervention that reliably increases mouse longevity. There is considerable phenotypic overla
Externí odkaz:
https://doaj.org/article/524c0a3d81ce4f4788b018626ff937bd
Autor:
Andrzej Bartke, Michal M. Masternak, Adam Gesing, Vinal Menon, Liou Y. Sun, Denise S. Wiesenborn, Andrew Do, Xu Zhi, Adam Spong
Publikováno v:
Aging (Albany NY)
Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early‐life treatment with thyr
Autor:
Andrzej Bartke, Tamara Tchkonia, Darlene E. Berryman, Allyson K. Palmer, Tamar Pirtskhalava, Edward O. List, James L. Kirkland, Carlos Escande, Michal M. Masternak, Michael B. Stout, Richard A. Miller, Ellen R. Lubbers, Nathan K. LeBrasseur, Adam Spong, John J. Kopchick, Ann L. Oberg
Publikováno v:
Aging (Albany NY)
The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indic
Autor:
Tanvir Hossain, Adam Gesing, Michal M. Masternak, Xu Zhi, Andrzej Bartke, Adam Spong, Vinal Menon
Publikováno v:
Aging Cell
Ames dwarf (Prop1(df), df/df) mice are characterized by growth hormone (GH), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. Plasma levels of a
Autor:
Dong-Myung Shin, John J. Kopchick, Mariusz Z. Ratajczak, Magda Kucia, Adam Spong, Michal M. Masternak, R Liu, Katarzyna Mierzejewska, Janina Ratajczak, Andrzej Bartke
Publikováno v:
AGE. 35:315-330
It is well known that attenuated insulin/insulin-like growth factor signaling (IIS) has a positive effect on longevity in several animal species, including mice. Here, we demonstrate that a population of murine pluripotent very small embryonic-like s
Autor:
Andrzej Bartke, Ravneet K. Boparai, Larry F. Hughes, Feiya Wang, Michal M. Masternak, Reyhan Westbrook, Yimin Fang, John J. Kopchick, Teresa Liberati, Adam Gesing, Adam Spong, Adam B. Salmon
Publikováno v:
Aging Cell. 11:73-81
Mice with targeted deletion of the growth hormone receptor (GHRKO mice) are growth hormone (GH) resistant, small, obese, hypoinsulinemic, highly insulin sensitive and remarkably long-lived. To elucidate the unexpected coexistence of adiposity with im
Autor:
James M. Harper, Andrzej Bartke, Michal M. Masternak, Jacob A. Panici, Richard A. Miller, Adam Spong
Publikováno v:
The FASEB Journal. 24:5073-5079
Hypopituitary Ames dwarf mice were injected either with growth hormone (GH) or thyroxine for a 6-wk period to see whether this intervention would reverse their long life span or the resistance of their cells to lethal stresses. Ames dwarf mice surviv
Autor:
Jacob A. Panici, James M. Harper, Richard A. Miller, Andrzej Bartke, Adam Spong, Michal M. Masternak
Publikováno v:
The FASEB Journal. 24:5073-5079
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :24-30
The disruption of the growth hormone (GH) axis in mice promotes insulin sensitivity and is strongly correlated with extended longevity. Ames dwarf (Prop1(df), df/df) mice are GH, prolactin (PRL), and thyrotropin (TSH) deficient and live approximately