Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Adam Sike"'
Autor:
Sudhir Kumar Chauhan, Claire Dunn, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Gjertrud Skorstad, Adam Sike, Bjørnar Gilje, Sunil Xavier Raj, Kanutte Huse, Bjørn Naume, Jon Amund Kyte
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Immunotherapies blocking the PD-1/PD-L1 checkpoint show some efficacy in metastatic breast cancer (mBC) but are often hindered by immunosuppressive mechanisms. Understanding these mechanisms is crucial for personalized treatments, with perip
Externí odkaz:
https://doaj.org/article/21138a5be7fa4ef6868ac4e8d5f2a5bf
Autor:
Yixin Jin, Claire Dunn, Irene Persiconi, Adam Sike, Gjertrud Skorstad, Carole Beck, Jon Amund Kyte
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 586 (2024)
We have developed a chimeric antigen receptor (CAR) against the six-transmembrane epithelial antigen of prostate-1 (STEAP1), which is expressed in prostate cancer, Ewing sarcoma, and other malignancies. In the present study, we investigated the effec
Externí odkaz:
https://doaj.org/article/a629e6a06cd2429d8ab78ab7f593e619
Autor:
Yixin Jin, Kristina Berg Lorvik, Yang Jin, Carole Beck, Adam Sike, Irene Persiconi, Emilie Kvaløy, Fahri Saatcioglu, Claire Dunn, Jon Amund Kyte
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 189-206 (2022)
Chimeric antigen receptors (CARs) that retarget T cells against CD19 show clinical efficacy against B cell malignancies. Here, we describe the development of a CAR against the six-transmembrane epithelial antigen of prostate-1 (STEAP1), which is expr
Externí odkaz:
https://doaj.org/article/78ece43bd6684e589e295a37b73f23e1
Autor:
Carole Beck, Nicholas Paul Casey, Irene Persiconi, Neda Nejati Moharrami, Adam Sike, Yixin Jin, Jon Amund Kyte
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 459 (2023)
Therapy employing T cells modified with chimeric antigen receptors (CARs) is effective in hematological malignancies but not yet in solid cancers. CAR T cell activity in solid tumors is limited by immunosuppressive factors, including transforming gro
Externí odkaz:
https://doaj.org/article/cc6b3e2ca1914ce4b4c0035c66af2581
Autor:
Yixin Jin, Kristina Berg Lorvik, Yang Jin, Carole Beck, Adam Sike, Irene Persiconi, Emilie Kvaløy, Fahri Saatcioglu, Claire Dunn, Jon Amund Kyte
Publikováno v:
Molecular therapy oncolytics. 26
Chimeric antigen receptors (CARs) that retarget T cells against CD19 show clinical efficacy against B cell malignancies. Here, we describe the development of a CAR against the six-transmembrane epithelial antigen of prostate-1 (STEAP1), which is expr
Autor:
Adám Sike, Enikő Nagy, Balázs Vedelek, Dávid Pusztai, Péter Szerémy, Anikó Venetianer, Imre M Boros
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84915 (2014)
The multidrug-resistant phenotype of tumor cells is acquired via an increased capability of drug efflux by ABC transporters and causes serious problems in cancer treatment. With the aim to uncover whether changes induced by epigenetic mechanisms in t
Externí odkaz:
https://doaj.org/article/0e2ae1dea29841c2980015e76d8c4d76