Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Adam Siddiqui-Jain"'
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance. Although drug combination therapies were originally devised primarily by empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009230c7b846415ab8368b86d944ad43
https://doi.org/10.1158/1535-7163.c.6536134.v1
https://doi.org/10.1158/1535-7163.c.6536134.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 148K, The effects of CK2, MDC1 or XRCC1 depletion by siRNA on Gamma-H2AX levels induced by cisplatin or gemcitabine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fb6cb4e739d4f966916283f31a97e5
https://doi.org/10.1158/1535-7163.22499401.v1
https://doi.org/10.1158/1535-7163.22499401.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 97K, Quantified western blots for Gamma-H2AX and cleaved PARP levels normalized to �eta-actin levels from cisplatin or gemcitabine combinations with CX-4945.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e37083b780678c4a83fbc6e1748ed1
https://doi.org/10.1158/1535-7163.22499404.v1
https://doi.org/10.1158/1535-7163.22499404.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 1.0MB, The global role of CK2 in DNA repair and cancer therapies that potentially rely on CK2 mediated repair mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9190126d915dc4ca655ca09925838
https://doi.org/10.1158/1535-7163.22499398
https://doi.org/10.1158/1535-7163.22499398
Autor:
William G. Rice, Kenna Anderes, Daniel Von Hoff, John K. C. Lim, Jeffrey P. Whitten, Katy Trent, Chris Proffitt, Caroline B. Ho, Josh Bliesath, Amy Lin, Michael Schwaebe, Sean O'Brien, Adam Siddiqui-Jain, Denis Drygin
Supplementary Methods and Materials from Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507050d577b19fc474daaa9d68bdaef
https://doi.org/10.1158/0008-5472.22378134
https://doi.org/10.1158/0008-5472.22378134
Autor:
William G. Rice, Kenna Anderes, David Ryckman, Ross D. Hannan, Megan J. Bywater, Elaine Sanij, Jaclyn E. Quin, Nicole Streiner, Adam Siddiqui-Jain, Michael K. Schwaebe, Mustapha Haddach, Mayuko Omori, Chris Proffitt, Sean E. O'Brien, Caroline B. Ho, Josh Bliesath, Amy Lin, Denis Drygin
Supplementary Materials from Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b64b9899bae18205e730a978712b0
https://doi.org/10.1158/0008-5472.22387916.v1
https://doi.org/10.1158/0008-5472.22387916.v1
Autor:
Kenna Anderes, William G. Rice, David M. Ryckman, Michael K. Schwaebe, Chris Proffitt, Caroline Ho, Nanni Huser, Mayuko Omori, Josh Bliesath, Sean E. O'Brien, Fabrice Pierre, Peter Chua, Nicole Streiner, Denis Drygin, Adam Siddiqui-Jain
Malignant transformation and maintenance of the malignant phenotype depends on oncogenic and non-oncogenic proteins that are essential to mediate oncogene signaling and to support the altered physiologic demands induced by transformation. Protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1119ad46a45018a2830b6d70f1b000dd
https://doi.org/10.1158/0008-5472.c.6501576
https://doi.org/10.1158/0008-5472.c.6501576
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:934-941
Microtubule-targeting agents are important tools in cancer treatment. Generating novel microtubule targeting agents with novel pharmacology could dramatically expand the utility of this class of drugs. Here we characterize the pharmacology of recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18362db7379817a11923050c11155b7
https://doi.org/10.1016/j.bmcl.2018.01.053
https://doi.org/10.1016/j.bmcl.2018.01.053
Autor:
Clifford J. Whatcott, Ethika Tyagi, David J. Bearss, Steven L. Warner, Yuta Matsumura, Adam Siddiqui-Jain, Jason M. Foulks
Publikováno v:
Cancer Research. 80:5813-5813
Cyclin-dependent kinase 9 (CDK9) is a promising target for cancer therapy due to its regulation of RNA polymerase II (RPB1) and key downstream anti-apoptosis proteins such as myeloid cell leukemia-1 (MCL-1). TP-1287 is a novel oral prodrug of alvocid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146f0234c0841fc1196fad8154add74c
https://doi.org/10.1158/1538-7445.am2020-5813
https://doi.org/10.1158/1538-7445.am2020-5813
Autor:
Ethika Tyagi, Adam Siddiqui-Jain, Yuta Matsumura, Evita Weagel, Steven L. Warner, David J. Bearss, Jason M. Foulks, Tetyana V. Forostyan, Clifford J. Whatcott
Publikováno v:
Molecular Cancer Therapeutics. 18:C081-C081
Prostate cancer is the most prevalent cancer in men, comprising 20% of all new cancer cases in United States, as per the Cancer Statistics, 2019. Many therapies for prostate cancer function by lowering androgen levels and include androgen deprivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3642f568f4265a1ce55a8799e79b9d22
https://doi.org/10.1158/1535-7163.targ-19-c081
https://doi.org/10.1158/1535-7163.targ-19-c081