Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Adam Shahine"'
Autor:
Tanja D de Gruijl, Roeland Lameris, Jamie Rossjohn, Myrthe Veth, David Lutje Hulsik, Adam Shahine, Bart Westerman, Dale I Godfrey, Patricia Brouwer, Hans J van der Vliet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies. Antibody-mediated targeting of CD1d on multiple myeloma cell
Externí odkaz:
https://doaj.org/article/44eecee2a3e44705a7cd0649a4af661d
Autor:
Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derive
Externí odkaz:
https://doaj.org/article/8b688ab776554395acd758b05b541c3e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2617 (2021)
T cells represent a critical arm of our immune defense against pathogens. Over the past two decades, considerable inroads have been made in understanding the fundamental principles underpinning the molecular presentation of peptide-based antigens by
Externí odkaz:
https://doaj.org/article/9b5fc59f470e45f28305884cb84d042b
Autor:
Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D. Tuttle, Laurent Gapin, Jérôme Le Nours, D. Branch Moody, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-r
Externí odkaz:
https://doaj.org/article/6334ebee5b454f54b0c32fa67fdc1261
Publikováno v:
Current Opinion in Immunology. 83:102339
Autor:
Tonatiuh A. Ocampo, Adrian Hayday, Adam Shahine, Jamie Rossjohn, Benjamin S. Gully, Pierre Vantourout, D. Branch Moody, Ildiko Van Rhijn, Josephine F. Reijneveld
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944-22952. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944. National Academy of Sciences
γδ T cells form an abundant part of the human cellular immune system, where they respond to tissue damage, infection, and cancer. The spectrum of known molecular targets recognized by Vδ1-expressing γδ T cells is becoming increasingly diverse. H
The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)
Autor:
Matthew A. Perugini, Sarah Preston, Adam Shahine, David Piedrafita, Dhanasekaran Sakthivel, Robin B. Gasser, M D Shakif-Azam, Jorge F. González, Julia N. Hernández, Travis Clarke Beddoe, Jamie Rossjohn, Els N.T. Meeusen, Peter Lock, Tatiana P. Soares da Costa
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-8 (2020)
Communications Biology
Communications Biology
Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identi
Autor:
Gwennaëlle C. Monnot, Marcin Wegrecki, Tan-Yun Cheng, Yi-Ling Chen, Brigitte N. Sallee, Reka Chakravarthy, Ioanna Maria Karantza, Shin Yi Tin, Alexandra E. Khaleel, Isha Monga, Laura N. Uwakwe, Alice Tillman, Bin Cheng, Soundos Youssef, Soo Weei Ng, Adam Shahine, Javier A. Garcia-Vilas, Anne-Catrin Uhlemann, Lindsey A. Bordone, Arnold Han, Christine H. Rohde, Graham Ogg, D. Branch Moody, Jamie Rossjohn, Annemieke de Jong
Publikováno v:
Nature immunology. 24(1)
Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a presents microbial ligands from bacteria colonizing the skin is unclear. Here we identified CD1a-dependent
Autor:
Gijsbert A. van der Marel, Dennis Dam, Laura Marino, Jamie Rossjohn, D. Branch Moody, Jeroen D. C. Codée, Tan-Yun Cheng, Ildiko Van Rhijn, Thinh-Phat Cao, Josephine F. Reijneveld, Martin D. Witte, Dmitri V. Filippov, Adriaan J. Minnaard, Adam Shahine, Sara Suliman
Publikováno v:
Journal of Biological Chemistry, 297(4)
Journal of Biological Chemistry, 297(4), 1. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
Journal of Biological Chemistry, 297(4):101197. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Biological Chemistry, 297(4), 1. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
Journal of Biological Chemistry, 297(4):101197. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Whereas proteolytic cleavage is crucial for peptide presentation by classical major histocompatibility complex (MHC) proteins to T cells, glycolipids presented by CD1 molecules are typically presented in an unmodified form. However, the mycobacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1fe6f3f452d6963f984cd927cb195
Autor:
Adam Shahine
Publikováno v:
Molecular Immunology. 104:27-36
The CD1 family of glycoproteins are MHC class I-like molecules that present a wide array of self and foreign lipid antigens to T-cell receptors (TCRs) on T-cells. Humans express three classes of CD1 molecules, denoted as Group 1 (CD1a, CD1b, and CD1c