Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Adam Schafer"'
Autor:
Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E Ramirez, Norton P Peet, Michael Caffrey, Gregory R J Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://doaj.org/article/513584dcab26402ea212101359422d10
Autor:
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A. Davey, Han Cheng, Lijun Rong
Publikováno v:
Viruses, Vol 10, Iss 4, p 152 (2018)
The recent 2014–2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is avai
Externí odkaz:
https://doaj.org/article/42aeef8a6ba540aeb112ba13acc8a22e
Autor:
Norton P. Peet, Adam Schafer, Lijun Rong, Julianna Han, Balaji Manicassamy, Han Cheng, Jasmine T. Perez
Publikováno v:
Curr Med Chem
Background: Influenza viruses cause severe upper respiratory illness in children and the elderly during seasonal epidemics. Influenza viruses from zoonotic reservoirs can also cause pandemics with significant loss of life in all age groups. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4a90ec787623f17465495928e7de3c
https://doi.org/10.2174/0929867324666170920165926
https://doi.org/10.2174/0929867324666170920165926
Autor:
Hyun Lee, Adam Schafer, Lijun Rong, Norton P. Peet, Yangfeng Li, Raghad Nowar, Rui Xiong, Erica Ollmann Saphire, Han Cheng, Michael Caffrey, Laura Cooper, Benjamin E. Ramirez, Gregory R. J. Thatcher
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
PLoS Pathogens
PLoS Pathogens
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e2e2dba33d62491007061fd573a91b
https://doaj.org/article/513584dcab26402ea212101359422d10
https://doaj.org/article/513584dcab26402ea212101359422d10
Autor:
Katherine Dye, Yangfeng Li, Adam Schafer, Lijun Rong, Raghad Nowar, Rui Xiong, Zhengnan Shen, Han Cheng, Manu Anantpadma, Robert A. Davey, Bani Medegan Fagla, Gregory R. J. Thatcher, Laura Cooper
Publikováno v:
J Med Chem
Filoviridae, including Ebola (EBOV) and Marburg (MARV) viruses, are emerging pathogens that pose a serious threat to public health. No agents have been approved to treat filovirus infections, representing a major unmet medical need. The selective est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceac47af00b029a01465ace24e344796
https://pubmed.ncbi.nlm.nih.gov/32886512
https://pubmed.ncbi.nlm.nih.gov/32886512
Autor:
Han Cheng, Lijun Rong, Norton P. Peet, Adam Schafer, Letitia Wong, Manu Anantpadma, Irina N. Gaisina, Robert A. Davey, Gregory R. J. Thatcher
Publikováno v:
J Med Chem
The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have discovered a new series of remarkably potent small molecule inhibitors of Ebola virus entry. These 4-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fec83c6d317babf7e714cf21796d988
https://pubmed.ncbi.nlm.nih.gov/32490678
https://pubmed.ncbi.nlm.nih.gov/32490678
Autor:
Adam Schafer, Veronica Soloveva, Feiyan Mo, Sina Bavari, Lijun Rong, Gregory R. J. Thatcher, Cary Retterer, Rui Xiong, Han Cheng
Publikováno v:
Antiviral Research
Ebola and Marburg are filoviruses and biosafety level 4 pathogens responsible for causing severe hemorrhagic fevers in humans with mortality rates up to 90%. The most recent outbreak in West Africa resulted in approximately 11,310 deaths in 28,616 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a558e6898487b4fba38d8bc0cb80cd55
https://doi.org/10.1016/j.antiviral.2018.07.003
https://doi.org/10.1016/j.antiviral.2018.07.003
Autor:
Veronica Soloveva, Dima N. Gharaibeh, Adam Schafer, Norton P. Peet, Cary Retterer, Tara Kenny, Rouzbeh Zamani, Lijun Rong, Han Cheng, Sina Bavari
Publikováno v:
Antiviral Research
Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f3d4e9e8ec9dfb90dbf235f2b665d8
https://doi.org/10.1016/j.antiviral.2017.06.015
https://doi.org/10.1016/j.antiviral.2017.06.015
Autor:
Lijun Rong, Balaji Manicassamy, Jasmine T. Perez, Norton P. Peet, Adam Schafer, Ruikun Du, Julianna Han, Han Cheng, Charles Lee
Publikováno v:
Current medicinal chemistry. 25(38)
Ebola virus has caused 26 outbreaks in 10 different countries since its identification in 1976, making it one of the deadliest emerging viral pathogens. The most recent outbreak in West Africa from 2014-16 was the deadliest yet and culminated in 11,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9689f86acf6ae30bb01ce615642ed
https://pubmed.ncbi.nlm.nih.gov/29032747
https://pubmed.ncbi.nlm.nih.gov/29032747
Autor:
Paul D. Farrall, Adam Schafer, Thomas Engel, David Brinkley, Gerhard Gantner, Amy Szuchmacher, Michelle Dietrich
Publikováno v:
Surface Science. 395:292-306
The adsorption-desorption kinetics of H2O have been studied on three well-defined surface configurations of TiO2(110) using temperature programmed desorption (TPD) and modulated molecular beam scattering in order to measure the extent of dissociative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8861e4fcda7d0002ac496df2dd76d110
https://doi.org/10.1016/s0039-6028(97)00633-x
https://doi.org/10.1016/s0039-6028(97)00633-x