Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Adam S. Dingens"'
Autor:
Adam S. Dingens, Katharine H. D. Crawford, Amanda Adler, Sarah L. Steele, Kirsten Lacombe, Rachel Eguia, Fatima Amanat, Alexandra C. Walls, Caitlin R. Wolf, Michael Murphy, Deleah Pettie, Lauren Carter, Xuan Qin, Neil P. King, David Veesler, Florian Krammer, Jane A. Dickerson, Helen Y. Chu, Janet A. Englund, Jesse D. Bloom
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
COVID-19 disease is less common in children than adults, but the extent to which SARS-CoV-2 infections are missed through symptom-driven testing is not well understood. In this study, the authors show that approximately 1% of children seeking care fo
Externí odkaz:
https://doaj.org/article/399ad20101ad4ac9854352e24ec39d01
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100255- (2021)
Summary: Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis for coronavirus disease 2019 (COVID-19). However, ongoing evolution of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can render monoclona
Externí odkaz:
https://doaj.org/article/eab24cccb8eb433c98bbf08707f5c672
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened her
Externí odkaz:
https://doaj.org/article/f1374489112c4b6484f89a474867ce79
Autor:
Katherine L. Williams, Bingjie Wang, Dana Arenz, James A. Williams, Adam S. Dingens, Valerie Cortez, Cassandra A. Simonich, Stephanie Rainwater, Dara A. Lehman, Kelly K. Lee, Julie Overbaugh
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 682-691 (2018)
Summary: Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals with broad and potent plasma neutralizing activity targeting one epitope have gui
Externí odkaz:
https://doaj.org/article/d2f932fc2bb3434597cf2cf86c15ef2e
Autor:
Keshet Ronen, Adam S. Dingens, Susan M. Graham, Walter Jaoko, Kishor Mandaliya, R. Scott McClelland, Julie Overbaugh
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 216-224 (2017)
HIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response to natural HIV infection. T
Externí odkaz:
https://doaj.org/article/b5477b3bbd3f476cac391cc470ef03e8
Autor:
Katharine H. D. Crawford, Rachel Eguia, Adam S. Dingens, Andrea N. Loes, Keara D. Malone, Caitlin R. Wolf, Helen Y. Chu, M. Alejandra Tortorici, David Veesler, Michael Murphy, Deleah Pettie, Neil P. King, Alejandro B. Balazs, Jesse D. Bloom
Publikováno v:
Viruses, Vol 12, Iss 5, p 513 (2020)
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-Co
Externí odkaz:
https://doaj.org/article/88a2dcbba5204bbe892d526add0ceb42
Publikováno v:
Viruses, Vol 12, Iss 2, p 241 (2020)
Although Rhesus macaques are an important animal model for HIV-1 vaccine development research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic determinant of this species-specific restriction is a non-synonymous muta
Externí odkaz:
https://doaj.org/article/1e6e82d476cd4291ad762548174f9288
Autor:
Katherine L. Williams, Valerie Cortez, Adam S. Dingens, Johannes S. Gach, Stephanie Rainwater, Julie F. Weis, Xuemin Chen, Paul Spearman, Donald N. Forthal, Julie Overbaugh
Publikováno v:
EBioMedicine, Vol 2, Iss 10, Pp 1464-1477 (2015)
HIV-specific antibodies (Abs) can reduce viral burden by blocking new rounds of infection or by destroying infected cells via activation of effector cells through Fc–FcR interaction. This latter process, referred to as antibody-dependent cellular c
Externí odkaz:
https://doaj.org/article/6174c86b170e432ebd34d500fcb54b17
Publikováno v:
Viruses, Vol 11, Iss 5, p 439 (2019)
Identifying drug resistance mutations is important for the clinical use of antivirals and can help define both a drug’s mechanism of action and the mechanistic basis of resistance. Resistance mutations are often identified one-at-a-time by studying
Externí odkaz:
https://doaj.org/article/fbbcb787aca742a9ba6283e3873f56d8
Autor:
Adam S Dingens, Payal Pratap, Keara Malone, Sarah K Hilton, Thomas Ketas, Christopher A Cottrell, Julie Overbaugh, John P Moore, PJ Klasse, Andrew B Ward, Jesse D Bloom
Publikováno v:
eLife, Vol 10 (2021)
Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use tw
Externí odkaz:
https://doaj.org/article/fa6f1f9b6b094cd8a36eefa873071ef2