Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adam S Neal"'
Autor:
Cheryl Wotus, Travis R Lilley, Adam S Neal, Nicole L Suleiman, Stefanie C Schmuck, Benjamin L Smarr, Brian J Fischer, Horacio O de la Iglesia
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68793 (2013)
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; however, the independent contributions from oscillators within the different subregions of the SCN to the glucocorticoid rhythm remain unclear. Here, we use
Externí odkaz:
https://doaj.org/article/25f994d611064355be8eabd5c77f74df
Autor:
Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 759-772.e10 (2019)
Summary: Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by s
Externí odkaz:
https://doaj.org/article/be7e1143ef2a432fb03f9abb2af5253d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 305 (2020)
One of the major challenges in the treatment of cancer are differential responses of patients to existing standard of care anti-cancer drugs. These differential responses may, in part, be due to a diverse range of genomic, epigenomic, proteomic, and
Externí odkaz:
https://doaj.org/article/7cd203bc58a04d3da6298ac6189af0cd
Autor:
Ian R. Sweet, Benjamin J. Reed, Huiliang Zhang, Austin M. Rountree, Adam S. Neal, Kelly Kernan, William R. A. Osborne, Brian Van Yserloo, Wang Wang
Publikováno v:
Biochemical Journal. 473:4443-4456
A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic and pathophysiologic states. Current methods do not provide the sensitivity, specificity and sp
Autor:
Craig W. Philips, Daniel L. Cook, Gamal Khalil, Dominic P. Williams, Adam S. Neal, Peter Newham, Ian R. Sweet, Terrance J. Kavanagh, Austin M. Rountree
Publikováno v:
Toxicological Sciences. 148:594-602
There is a general need to detect toxic effects of drugs during preclinical screening. We propose that increased sensitivity of xenobiotics toxicity combined with improved in vitro physiological recapitulation will more accurately assess potentially
Autor:
Yassmin Parsaei, Xiaojian Zhao, Ian R. Sweet, Ali Nasiri, Orian H. Shirihai, Anila K. Madiraju, Tiago C. Alves, Sean R. Jesinkey, Rebecca L. Cardone, William M. Philbrick, Xinran Liu, Gina M. Butrico, Dane M. Wolf, Anthony J.A. Molina, Adam S. Neal, Richard G. Kibbey, Austin M. Rountree, Orlando Yarborough, John Sterpka
Publikováno v:
Cell reports, vol 28, iss 3
Cell Reports, Vol 28, Iss 3, Pp 759-772.e10 (2019)
Cell Reports, Vol 28, Iss 3, Pp 759-772.e10 (2019)
Summary: Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by s
Autor:
Austin M. Rountree, Sarah A. White, Francis Kim, Dan S. Luciani, Ian R. Sweet, Jared Radtke, Mark Lisowski, Adam S. Neal, Christiane S. Hampe, Norma O. Rizzo
Publikováno v:
Journal of Biological Chemistry. 289:19110-19119
The aim of the study was to assess the relative control of insulin secretion rate (ISR) by calcium influx and signaling from cytochrome c in islets where, as in diabetes, the metabolic pathways are impaired. This was achieved either by culturing isol
Autor:
Michael W. Schwartz, Christiane S. Hampe, Vincenzo Cirulli, Jared Radtke, Ian R. Sweet, Jianzhu Yin, Jonathan D. Posner, Adam S. Neal, Austin M. Rountree
Publikováno v:
Scientific Reports
Functional characterization of individual cells within heterogeneous tissue preparations is challenging. Here, we report the development of a versatile imaging method that assesses single cell responses of various endpoints in real time, while identi
Autor:
Brian J. Fischer, Travis R. Lilley, Horacio O. de la Iglesia, Cheryl Wotus, Stefanie C. Schmuck, Nicole L. Suleiman, Benjamin L. Smarr, Adam S. Neal
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e68793 (2013)
PLoS ONE, Vol 8, Iss 7, p e68793 (2013)
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; however, the independent contributions from oscillators within the different subregions of the SCN to the glucocorticoid rhythm remain unclear. Here, we use