Zobrazeno 1 - 10 of 112 pro vyhledávání: '"Adam S Adler"'
1
Akademický článek
Predicting antibody binders and generating synthetic antibodies using deep learning
Autor: Yoong Wearn Lim, Adam S. Adler, David S. Johnson
Publikováno v: mAbs, Vol 14, Iss 1 (2022)
The antibody drug field has continually sought improvements to methods for candidate discovery and engineering. Historically, most such methods have been laboratory-based, but informatics methods have recently started to make an impact. Deep learning
Externí odkaz: https://doaj.org/article/4acccd0633eb4a30a55c0019db29197d
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2
Akademický článek
Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment
Autor: Yoong Wearn Lim, Garry L. Coles, Savreet K. Sandhu, David S. Johnson, Adam S. Adler, Erica L. Stone
Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background The anti-tumor activity of anti-PD-1/PD-L1 therapies correlates with T cell infiltration in tumors. Thus, a major goal in oncology is to find strategies that enhance T cell infiltration and efficacy of anti-PD-1/PD-L1 therapy. TGF
Externí odkaz: https://doaj.org/article/00fd9007a4614376a1b047d12d4c3430
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4
Akademický článek
Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
Autor: Jan Fredrik Simons, Yoong Wearn Lim, Kyle P. Carter, Ellen K. Wagner, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v: mAbs, Vol 12, Iss 1 (2020)
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated an
Externí odkaz: https://doaj.org/article/ac6112ed99b44416933c0b907771131b
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