Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Adam S, Hogendorf"'
1
Akademický článek
N-Skatyltryptamines—Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential
Autor: Agata Hogendorf, Adam S. Hogendorf, Rafał Kurczab, Grzegorz Satała, Bernadeta Szewczyk, Paulina Cieślik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staroń, Ryszard Bugno, Beata Duszyńska, Andrzej J. Bojarski
Publikováno v: Molecules, Vol 26, Iss 15, p 4605 (2021)
A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activi
Externí odkaz: https://doaj.org/article/161dfe1128284230be1a6f666c15721d
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2
Akademický článek
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
Autor: Adam S. Hogendorf, Agata Hogendorf, Rafał Kurczab, Grzegorz Satała, Tomasz Lenda, Maria Walczak, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Joanna M. Wierońska, Monika Woźniak, Paulina Cieślik, Ryszard Bugno, Jakub Staroń, Andrzej J. Bojarski
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van Leusen multicomponent reaction. The chemotype is the first example of low-basicity scaffolds exhibiting high affinity for 5-HT7 receptor together with agonist func
Externí odkaz: https://doaj.org/article/b2815ce3d4e34da783160c0d85d688cb
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4
Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats
Autor: Agnieszka Nikiforuk, Adam S. Hogendorf, Agata Kuziak, Jakub Staroń, Martyna Krawczyk, Ryszard Bugno, Piotr Popik
Publikováno v: Journal of Psychopharmacology. 33:1447-1455
Purpose: Like other psychedelics, D-lysergic acid diethylamide (LSD) affects numerous serotonin receptors, and according to the current dogma, the 5-HT2A receptors are considered the main target for its hallucinogenic effects. LSD, however, also disp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaeac33cfe52a352984adc9e0757618
https://doi.org/10.1177/0269881119867603
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6
How can fluorine directly and indirectly affect the hydrogen bonding in molecular systems? - A case study for monofluoroanilines
Autor: Rafał Kurczab, Rafał Kafel, Adam S. Hogendorf, Marek Żylewski, Wojciech Pietruś, Justyna Kalinowska-Tłuścik, Ewa Machalska, Andrzej J. Bojarski, Malgorzata Baranska
Publikováno v: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 252
Hydrogen bonds (HBs) directly engaging fluorine has been extensively studied, but the indirect effect of fluorine on adjacent donors and acceptors is poorly understood and still difficult to predict. The indirect and direct effect of the fluorination
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c10051cb44aeee0546965e43c67e36d
https://pubmed.ncbi.nlm.nih.gov/33588362
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7
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
Autor: Oskar Popik, Adam S. Hogendorf, Mikołaj Matłoka, Rafal Moszczynski, Agnieszka Nikiforuk, Agnieszka Potasiewicz, Piotr Popik, Joanna Golebiowska, Jeffrey M. Witkin, Agata Kuziak, Shaun Yon-Seng Khoo
Although (S)-ketamine was approved for use in treatment-resistant depression in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0f4c1a98b634c8feec99d9671ff685
https://doi.org/10.1016/j.pbb.2020.173011
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9
The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT6 receptor antagonists and beyond
Autor: Anna Krawczuk, Justyna Kalinowska-Tłuścik, Grzegorz Satała, Andrzej J. Bojarski, Adam S. Hogendorf, Jakub Staroń, Stefan Mordalski, Dawid Warszycki
Publikováno v: RSC Advances. 8:18672-18681
The development of compounds with enhanced activity and selectivity by a conserved spatial orientation of the pharmacophore elements has a long history in medicinal chemistry. Rigidified compounds are an example of this concept. However, the intramol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbaf7c8b62245b245337ccf42c1684a
https://doi.org/10.1039/c8ra03107j
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10
Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine
Autor: Dawid Warszycki, Ryszard Bugno, Agata Hogendorf, Rafał Kurczab, Beata Duszyńska, Adam S. Hogendorf, Andrzej J. Bojarski, Wojciech Pietruś, Tomasz Lenda, Jakub Staroń, Grzegorz Satała, Anna Wantuch
Publikováno v: European Journal of Medicinal Chemistry. 220:113533
The selective serotonin reuptake inhibitors (SSRIs), acting at the serotonin transporter (SERT), are one of the most widely prescribed antidepressant medications. All five approved SSRIs possess either fluorine or chlorine atoms, and there is a limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92afc552b4b8acf7ae6d6795197acdc8
https://doi.org/10.1016/j.ejmech.2021.113533
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