Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Adam S, Helms"'
Autor:
Donia W. Ahmed, Madeline K. Eiken, Samuel J. DePalma, Adam S. Helms, Rachel L. Zemans, Jason R. Spence, Brendon M. Baker, Claudia Loebel
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108472- (2023)
Summary: Mechanical forces provide critical biological signals to cells during healthy and aberrant organ development as well as during disease processes in adults. Within the cardiopulmonary system, mechanical forces, such as shear, compressive, and
Externí odkaz:
https://doaj.org/article/e7b858929c674a51bceb3ef902c56cbc
Autor:
Juan R. Gimeno, Iacopo Olivotto, Ana Isabel Rodríguez, Carolyn Y. Ho, Adrián Fernández, Alejandro Quiroga, Mari Angeles Espinosa, Cristina Gómez‐González, María Robledo, Lucas Tojal‐Sierra, Sharlene M. Day, Anjali Owens, Roberto Barriales‐Villa, Jose María Larrañaga, Jose Rodríguez‐Palomares, Maribel González‐del‐Hoyo, Jesús Piqueras‐Flores, Nosheen Reza, Olga Chumakova, Euan A. Ashley, Victoria Parikh, Matthew Wheeler, Daniel Jacoby, Alexandre C. Pereira, Sara Saberi, Adam S. Helms, Eduardo Villacorta, María Gallego‐Delgado, Daniel deCastro, Fernando Domínguez, Tomás Ripoll‐Vera, Esther Zorio‐Grima, José Carlos Sánchez‐Martínez, Ana García‐Álvarez, Elena Arbelo, María Victoria Mogollón, María Eugenia Fuentes‐Cañamero, Elias Grande, Carlos Peña, Lorenzo Monserrat, Neal K. Lakdawala, Dilema International Cardiomyopathy and Heart Failure Registry and international SHaRe (Sarcomeric Human Cardiomyopathy Registry) Investigators group
Publikováno v:
ESC Heart Failure, Vol 9, Iss 4, Pp 2189-2198 (2022)
Abstract Aims To describe the natural history of SARS‐CoV‐2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Methods and results Three hundred and five patien
Externí odkaz:
https://doaj.org/article/91483f6a810740f68b374d86c8670633
Autor:
Yao-Chang Tsan, Samuel J. DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu-Wei Wu, Brynn Elder, Isabella Panse, Kathryn Ufford, Daniel L. Matera, Sabrina Friedline, Thomas S. O’Leary, Nadab Wubshet, Kenneth K. Y. Ho, Michael J. Previs, David Nordsletten, Lori L. Isom, Brendon M. Baker, Allen P. Liu, Adam S. Helms
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale
Externí odkaz:
https://doaj.org/article/866175855d3a4449bdab9d5e10355c8b
Autor:
Sarah Abou Alaiwi, Thomas M. Roston, Peter Marstrand, Brian Lee Claggett, Victoria N. Parikh, Adam S. Helms, Jodie Ingles, Rachel Lampert, Neal K. Lakdawala, Michelle Michels, Anjali T. Owens, Joseph W. Rossano, Sara Saberi, Dominic J. Abrams, Euan A. Ashley, Christopher Semsarian, John C. Stendahl, James S. Ware, Erin Miller, Thomas D. Ryan, Mark W. Russell, Sharlene M. Day, Iacopo Olivotto, Christoffer R. Vissing, Carolyn Y. Ho
Publikováno v:
Circulation.
BACKGROUND: The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de6b0064003d77ee80f48de33a990fd
https://doi.org/10.1161/circulationaha.122.062517
https://doi.org/10.1161/circulationaha.122.062517
Publikováno v:
JACC: Basic to Translational Science
Highlights • Knowledge of the genetic etiologies of cardiomyopathies has created novel opportunities for treatments. • Emerging treatments targets include gene therapy, myofilament function, protein quality control, and metabolism. • Considerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c656f79b564e9e437a00ca02b88041ed
https://doi.org/10.1016/j.jacbts.2021.07.012
https://doi.org/10.1016/j.jacbts.2021.07.012
Autor:
Matthias G. Friedrich, Michelle Michels, Stefan K. Piechnik, Dana Dawson, Daniel Jacoby, Patrice Desvigne-Nickens, John P. DiMarco, William Bradlow, Christopher M. Kramer, Carolyn Y. Ho, Jeanette Schulz-Menger, Chiara Buccarelli-Ducci, Adam S. Helms, Michael Salerno, Hugh Watkins, Barbara Casadei, Lubna Choudhury, James A. White, Martin S. Maron, Jonathan W. Weinsaft, Paul Kolm, Amedeo Chiribiri, Anjali T. Owens, Sarahfaye Dolman, Evan Appelbaum, Hcmr Investigators, Raymond Y. Kwong, William S. Weintraub, Sherif F. Nagueh, Dong-Yun Kim, Milind Y. Desai, Stefan Neubauer, Michael Jerosch-Herold, Nancy L. Geller, Masliza Mahmod, Colin Berry
Publikováno v:
JACC Clin Electrophysiol
Objectives This study sought to identify predictors of major clinically important atrial fibrillation endpoints in hypertrophic cardiomyopathy. Background Atrial fibrillation (AF) is a common morbidity associated with hypertrophic cardiomyopathy (HCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038ece792bb3eeb7fd6f931202cf750d
https://doi.org/10.1016/j.jacep.2021.04.004
https://doi.org/10.1016/j.jacep.2021.04.004
Autor:
Andrea D. Thompson, Marcus J. Wagner, Juliani Rodriguez, Alok Malhotra, Steve Vander Roest, Ulla Lilienthal, Hao Shao, Jaime M. Yob, Benjamin L. Prosser, Adam S. Helms, Jason E. Gestwicki, David Ginsburg, Sharlene M. Day
Structured AbstractObjectiveWe aim to identify regulators of myosin binding protein C3 (MyBP-C) protein homeostasis.BackgroundVariants in myosin binding protein C3 (MYBPC3) account for approximately 50% of familial hypertrophic cardiomyopathy (HCM).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::281c9b5a6016155e592a2b1dcbe91e25
https://doi.org/10.1101/2022.10.08.511444
https://doi.org/10.1101/2022.10.08.511444
Autor:
Adam S. Helms, Peter Marstrand, Larry Han, Michelle Michels, Neal K. Lakdawala, Jodie Ingles, Joseph W. Rossano, Euan A. Ashley, Anjali T. Owens, Alexandre C. Pereira, Sara Saberi, Sunil Kapur, Daniel Jacoby, Samuel G. Wittekind, Victor Nauffal, Christopher Semsarian, Sharlene M. Day, Victoria N. Parikh, Carolyn Y. Ho, James S. Ware, Iacopo Olivotto
Publikováno v:
Eur Heart J
Aims Risk stratification algorithms for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) and regional differences in clinical practice have evolved over time. We sought to compare primary prevention implantable cardioverter defibrillat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490378bb93e50fa6edb498923d8a50ab
https://doi.org/10.1093/eurheartj/ehab598
https://doi.org/10.1093/eurheartj/ehab598
Autor:
Carolyn Y. Ho, Euan A. Ashley, James S. Ware, Sharlene M. Day, Sara Saberi, Joseph W. Rossano, Samuel G. Wittekind, Daniel Jacoby, Alexandre C. Pereira, Adam S. Helms, Iacopo Olivotto, Steven D. Colan, Michelle Michels, Jodie Ingles, Larry Han, Christopher Semsarian, Nicholas A Marston
Publikováno v:
European Heart Journal, 42(20), 1988-1996. Oxford University Press
Aims Childhood-onset hypertrophic cardiomyopathy (HCM) is far less common than adult-onset disease, thus natural history is not well characterized. We aim to describe the characteristics and outcomes of childhood-onset HCM. Methods and results We per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6cd3b9549dfed17dd23c4adcf79ac7
https://doi.org/10.1093/eurheartj/ehab148
https://doi.org/10.1093/eurheartj/ehab148
Autor:
Vi T. Tang, Kathryn Ufford, Zhaowen Tong, Allen P. Liu, Sabrina Friedline, Stephanie L. Bielas, Adam S. Helms, Amani S. Dobbs, Yao-Chang Tsan
Publikováno v:
Stem Cell Reports
Summary Disease modeling and pharmaceutical testing using cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) requires accurate assessment of contractile function. Micropatterning iPSC-CMs on elastic substrates controls cell shape a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154c591212a944f7d88f4f00063d3fdc
https://doi.org/10.1016/j.stemcr.2021.01.007
https://doi.org/10.1016/j.stemcr.2021.01.007