Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Adam Raes"'
Autor:
Jaak Billen, Sammy Goemaere, Roger Bouillon, Tom Fiers, Dorien Baetens, An Desloovere, Martine Cools, Adam Raes, Dirk Vanderschueren, Ivo Jans, E. De Baere, J. De Schepper, JM Kaufman
Publikováno v:
Bone. 81:89-96
Background Bi-allelic CYP24A1 mutations can cause idiopathic infantile hypercalcemia (IIH), adult-onset nephrocalcinosis, and possibly bone metabolism disturbances. It is currently unclear if heterozygous carriers experience clinical problems or bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2604a85724209879cf043c858f51f2
https://doi.org/10.1016/j.bone.2015.06.018
https://doi.org/10.1016/j.bone.2015.06.018
Autor:
Adam Raes, Alain J. Labro, Alessandro Grottesi, Mark S.P. Sansom, Diane Van Hoorick, Dirk J. Snyders
Publikováno v:
Scopus-Elsevier
The journal of general physiology
JOURNAL OF GENERAL PHYSIOLOGY
The Journal of General Physiology
The journal of general physiology
JOURNAL OF GENERAL PHYSIOLOGY
The Journal of General Physiology
Voltage-dependent K(+) channels transfer the voltage sensor movement into gate opening or closure through an electromechanical coupling. To test functionally whether an interaction between the S4-S5 linker (L45) and the cytoplasmic end of S6 (S6(T))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e392bb9972118ec2336205a3bb4f14
https://doi.org/10.1085/jgp.200810048
https://doi.org/10.1085/jgp.200810048
Publikováno v:
American journal of physiology: cell physiology
The Kv1–4 families of K+ channels contain a tandem proline motif (P XP) in the S6 helix that is crucial for channel gating. In human Kv1.5, replacing the first proline by an alanine resulted in a nonfunctional channel. This mutant was rescued by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0c3f1aeafadfe2600d85bb001b6b62
https://doi.org/10.1152/ajpcell.00479.2007
https://doi.org/10.1152/ajpcell.00479.2007
Publikováno v:
Acta ornithologica
During two hours of observation, a female Blackbird made approximately 30 attempts to catch fish, 20 of which were successful. The bird watched and followed a minnow shoal in shallow parts of the river, hopping from stone to stone in a way that resem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c29bed0ec41808f85c9b30300da681e
https://doi.org/10.3161/000164508x395351
https://doi.org/10.3161/000164508x395351
Publikováno v:
The Journal of Physiology. 585:325-337
Co-assembly of KCNQ1 α-subunits with KCNE1 β-subunits results in the channel complex underlying the cardiac IKs current in vivo. Like other voltage-gated K+ channels, KCNQ1 has a tetrameric configuration. The S6 segment of each subunit lines the io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164c8cce50591110c9fb5ff3c5ca85db
https://doi.org/10.1113/jphysiol.2007.145813
https://doi.org/10.1113/jphysiol.2007.145813
Publikováno v:
The Journal of Physiology. 583:959-969
The KChIP1b splice variant has been shown to induce slow recovery from inactivation for Kv4.2 whereas KChIP1a enhanced the recovery. Both splice variants differ only by the insertion of the exon1b, rich in aromatic residues (5/11). We analysed in det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8710ce477fce54d96ccb3c21c706794f
https://doi.org/10.1113/jphysiol.2007.139550
https://doi.org/10.1113/jphysiol.2007.139550
Publikováno v:
Biophysical journal
Human ether-a-go-go-related gene (HERG) potassium channels contribute to the repolarization of the cardiac action potential and display unique gating properties with slow activation and fast inactivation kinetics. Deletions in the N-terminal ‘proxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8abf1e20fa0aa24337739adae9c6bbb
Publikováno v:
The Journal of Physiology. 568:737-747
The subunit Kv6.3 encodes a voltage-gated potassium channel belonging to the group of electrically silent Kv subunits, i.e. subunits that do not form functional homotetrameric channels. The lack of current, caused by retention in the endoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4409ad24dcc8be6c7686e807709898
https://doi.org/10.1113/jphysiol.2005.090142
https://doi.org/10.1113/jphysiol.2005.090142
Publikováno v:
The journal of general physiology
The Journal of General Physiology
The Journal of General Physiology
Voltage-gated K+ channels play a central role in the modulation of excitability. In these channels, the voltage-dependent movement of the voltage sensor (primarily S4) is coupled to the (S6) gate that opens the permeation pathway. Because of the tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d99e9139e7c2e216704e09d35ea6ac1
https://doi.org/10.1085/jgp.200409194
https://doi.org/10.1085/jgp.200409194
Publikováno v:
Molecular and Cellular Neuroscience. 24:357-366
The beta-subunits of the KChIP family modulate properties and expression level of Kv4 channels. We report the cloning of the first splice variant of KChIP1 (KChIP1b) which contains an extra exon, rich in aromatic residues, in the amino terminus. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3080922769c3eabefea3782bd5807c
https://doi.org/10.1016/s1044-7431(03)00174-x
https://doi.org/10.1016/s1044-7431(03)00174-x