Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Adam R. Taylor"'
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 4 (2010)
We have previously shown that male rats exposed to gestational stress exhibit phenotypes resembling what is observed in schizophrenia, including hypersensitivity to amphetamine, blunted sensory gating, disrupted social behavior, impaired stress axis
Externí odkaz:
https://doaj.org/article/756fa4fd71014717b233e1ddf176be31
Autor:
Luke M Kraven, Adam R Taylor, Philip L Molyneaux, Toby M Maher, John E McDonough, Marco Mura, Ivana V Yang, David A Schwartz, Yong Huang, Imre Noth, Shwu Fan Ma, Astrid J Yeo, William A Fahy, R Gisli Jenkins, Louise V Wain
Publikováno v:
Thorax
BackgroundConsiderable clinical heterogeneity in idiopathic pulmonary fibrosis (IPF) suggests the existence of multiple disease endotypes. Identifying these endotypes would improve our understanding of the pathogenesis of IPF and could allow for a bi
Autor:
Hannah V, Woodcock, Jessica D, Eley, Delphine, Guillotin, Manuela, Platé, Carmel B, Nanthakumar, Matteo, Martufi, Simon, Peace, Gerard, Joberty, Daniel, Poeckel, Robert B, Good, Adam R, Taylor, Nico, Zinn, Matthew, Redding, Ellen J, Forty, Robert E, Hynds, Charles, Swanton, Morten, Karsdal, Toby M, Maher, Andrew, Fisher, Giovanna, Bergamini, Richard P, Marshall, Andy D, Blanchard, Paul F, Mercer, Rachel C, Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12557e14bc29bc74428c19dab93849b
Publikováno v:
Neuroscience Letters. 531:131-135
The cognitive deficits observed in schizophrenia are considered a core feature of the disease. Neuregulin-1 is a risk gene for schizophrenia that is involved in many neurodevelopmental and synaptic plasticity-related processes relevant to schizophren
Publikováno v:
Behavioural Brain Research. 224:223-232
Neuregulin 1 (NRG1) is an important growth factor involved in the development and plasticity of the central nervous system. Since its identification as a susceptibility gene for schizophrenia, several transgenic mouse models have been employed to elu
Autor:
Aron M. Geurts, Adam R. Taylor, Sara B. Taylor, James I. Koenig, B.Z. Kanaskie, Julie A. Markham
Publikováno v:
Physiology & Behavior. 104:205-214
Exposure to stress can result in an increased risk for psychiatric disorders, especially among genetically predisposed individuals. Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia and is also associated with psychotic bipolar disorder.
Publikováno v:
Neuron. 51:509-520
SummaryWe monitored single-neuron activity in the orbitofrontal cortex of rats performing a time-discounting task in which the spatial location of the reward predicted whether the delay preceding reward delivery would be short or long. We found that
Publikováno v:
Neuroscience. 249
The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put geneticall