Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adam R. M. Stewart"'
Autor:
Helena Kempski, Qian An, G A A Burke, Jonathan C. Strefford, M Martineau, Adam R. M. Stewart, M Dainton, Zoe J. Konn, David Webb, W Myooren, Christine J. Harrison, Mary Taj
Publikováno v:
Leukemia. 24:649-652
There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac514dc375c3c10fa3a90d84d6fc0f44
https://doi.org/10.1038/leu.2009.238
https://doi.org/10.1038/leu.2009.238
Autor:
G. Reza Jalali, Christine J. Harrison, Jonathan C. Strefford, Sarah Wright, Rachel L. Harris, Kerry E. Barber, Anthony V. Moorman, Mike Griffiths, Hazel M. Robinson, Zoë J. Broadfield, Louise Harewood, Adam R. M. Stewart, Fiona M. Ross, M Martineau, Kan L. Cheung
Publikováno v:
British Journal of Haematology. 129:520-530
Summary Interphase fluorescence in situ hybridization (iFISH) was used independently to reveal chromosomal abnormalities of prognostic importance in a large, consecutive series of children (n = 2367) with acute lymphoblastic leukaemia (ALL). The fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a2cbecdf29b06771d86138a0b0ff7
https://doi.org/10.1111/j.1365-2141.2005.05497.x
https://doi.org/10.1111/j.1365-2141.2005.05497.x
Autor:
Jonathan C. Strefford, Nick Bown, Sarina Sulong, Helen Parker, Sarah L. Wright, Anthony V. Moorman, Marian Case, Simon Bailey, Zoe J. Konn, Lynne Minto, Christine J. Harrison, Julie Irving, Adam R. M. Stewart, Andrew G. Hall, Kerry E. Barber
Publikováno v:
Blood. 113(1)
Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic leukemia (ALL) and frequency in biologically relevant subgroups. Mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c839a312dac7a0ff2463ee778e1dc301
https://pubmed.ncbi.nlm.nih.gov/18838613
https://pubmed.ncbi.nlm.nih.gov/18838613
Autor:
Christine J. Harrison, Jonathan C. Strefford, Kerry E. Barber, Zoe J. Konn, Andrew G. Hall, Adam R. M. Stewart, Helen Parker, Fiona M. Ross, Sarah L. Wright, Michael J. Griffiths, Julie Irving, Marian Case, Qian An, Anthony V. Moorman, Teresa Davies
Publikováno v:
Genes, chromosomescancer. 47(12)
The ETV6-RUNX1 fusion is the molecular consequence of the t(12;21)(p13;q22) seen in approximately 25% of children with acute lymphoblastic leukemia (ALL). Studies have shown that the fusion alone is insufficient for the initiation of leukemia; additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968fcc7ca4de8bc6f00d79fbc7cf0777
https://pubmed.ncbi.nlm.nih.gov/18767146
https://pubmed.ncbi.nlm.nih.gov/18767146
Autor:
Kerry E. Barber, Zoë J. Broadfield, Anthony V. Moorman, Adam R. M. Stewart, Jonathan C. Strefford, Sarah L. Wright, M Martineau, Christine J. Harrison
Publikováno v:
Genes, chromosomescancer. 46(5)
The t(1; 19)(q23;p 13.3) is one of the most common chromosomal abnormalities in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and usually gives rise to the TCF3-PBXI fusion gene. Additional rare, and sometimes cytogenetically cryptic, trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311a06fbb0c367922b75e7b03346dac4
https://pubmed.ncbi.nlm.nih.gov/17311319
https://pubmed.ncbi.nlm.nih.gov/17311319
Autor:
Anthony V. Moorman, Hazel M. Robinson, F W van Delft, Helen Worley, Christine J. Harrison, Sarah Wright, Jonathan C. Strefford, G Bettney, Fiona M. Ross, Vaskar Saha, Teresa Davies, Adam R. M. Stewart, Sandra Hing, Polly Talley, Mike Griffiths, Mark G. Atherton, Kerry E. Barber
Publikováno v:
Oncogene. 26(29)
Chromosomal abnormalities are important for the classification and risk stratification of patients with acute lymphoblastic leukemia (ALL). However, approximately 30% of childhood and 50% of adult patients lack abnormalities with clinical relevance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0275152e463acabc955a3d6a303eb3e1
https://pubmed.ncbi.nlm.nih.gov/17237825
https://pubmed.ncbi.nlm.nih.gov/17237825
Autor:
Kerry E. Barber, Jonathan C. Strefford, Sue Richards, Helen Parker, Sarah L. Wright, Chris Mitchell, Anthony V. Moorman, Zoe J. Konn, Sally E. Kinsey, Adam R. M. Stewart, O. B. Eden, Ajay Vora, Christine J. Harrison
Publikováno v:
Blood. 112:430-430
Approximately 20–25% of children with B-cell precursor ALL harbour the t(12;21) (p13;q22)/ETV6-RUNX1 fusion which has been associated, almost universally, with a favourable outcome. However, as some ETV6-RUNX1 patients relapse additional predictors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1fc38685c7831d6c760216349f1010
https://doi.org/10.1182/blood.v112.11.430.430
https://doi.org/10.1182/blood.v112.11.430.430
Autor:
Jonathan C. Strefford, Christine J. Harrison, Sarah Wright, Zoë J. Broadfield, Adam R. M. Stewart, Kerry E. Barber, M Martineau, Anthony V. Moorman
Publikováno v:
Blood. 108:2062-2062
Increasing numbers of genetic changes are being described in T lineage acute lymphoblastic leukaemia (T ALL), which may be used to classify patients into subgroups, defining multi-step oncogenic pathways. We have integrated the significant abnormalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719ea2024fe5c2f11f8e2bf44ead8e44
https://doi.org/10.1182/blood.v108.11.2062.2062
https://doi.org/10.1182/blood.v108.11.2062.2062