Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam R Lefferts"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although studies have identified the presence of gut-associated cells in the enthesis of joints affected by spondylarthritis (SpA), a direct link through cellular transit between the gut and joint has yet to be formally demonstrated. Using KikGR tran
Externí odkaz:
https://doaj.org/article/96ce9b50bee947af9591c297cbf5462a
Autor:
Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones, Kristine A. Kuhn
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of both diseases (CD-
Externí odkaz:
https://doaj.org/article/b7e8a04f6b5e45008107ad8d812fec37
Autor:
Mayara Garcia de Mattos Barbosa, Adam R. Lefferts, Daniel Huynh, Hui Liu, Yu Zhang, Beverly Fu, Jenna Barnes, Milagros Samaniego, Richard J. Bram, Raif S. Geha, Ariella Shikanov, Eline T. Luning Prak, Evan A. Farkash, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-media
Externí odkaz:
https://doaj.org/article/a070c085b731448ba55137aa11437ce9
Autor:
Jeffrey L. Platt, Mayara Garcia de Mattos Barbosa, Daniel Huynh, Adam R. Lefferts, Juhi Katta, Cyra Kharas, Peter Freddolino, Christine M. Bassis, Christiane Wobus, Raif Geha, Richard Bram, Gabriel Nunez, Nobuhiko Kamada, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only
Externí odkaz:
https://doaj.org/article/2aff0f4d4cf946c4a166ddace676d083
Autor:
Meagan E. Chriswell, Adam R. Lefferts, Michael R. Clay, Alex Ren Hsu, Jennifer Seifert, Marie L. Feser, Cliff Rims, Michelle S. Bloom, Elizabeth A. Bemis, Sucai Liu, Megan D. Maerz, Daniel N. Frank, M. Kristen Demoruelle, Kevin D. Deane, Eddie A. James, Jane H. Buckner, William H. Robinson, V. Michael Holers, Kristine A. Kuhn
Publikováno v:
Science Translational Medicine. 14
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that occurs with disease. However, the connection between the mucosa and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fccfa630d531c39b9143ebc18b089b
https://doi.org/10.1126/scitranslmed.abn5166
https://doi.org/10.1126/scitranslmed.abn5166
Autor:
Meagan Chriswell, Adam R. Lefferts, Michael Clay, Alex Hsu, Jennifer Seifert, Marie L. Feser, Cliff Rims, Michelle Bloom, Elizabeth A. Bemis, M. Kristen Demoruelle, Kevin D. Deane, Eddie A. James, Jane H. Buckner, William H. Robinson, V. Michael Holers, Kristine A. Kuhn
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation and/or perpetuation of the systemic autoimmunity that occurs with disease. However, the connection between the mucosa a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::124fc7988c4caede50f0e006fc6331a5
https://doi.org/10.1101/2022.06.09.495381
https://doi.org/10.1101/2022.06.09.495381
Autor:
Frank I. Scott, Kristine A. Kuhn, Mark E. Gerich, Blair Fennimore, Kenneth L. Jones, Andrew Stahly, Emilie Regner, Adam R. Lefferts, Alison E. Freeman, Becky O’Rourke
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of both diseases (CD-axSpA) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28bb11bbfbda673704e70019fea3c6c
https://doaj.org/article/b7e8a04f6b5e45008107ad8d812fec37
https://doaj.org/article/b7e8a04f6b5e45008107ad8d812fec37
Autor:
Mayara Garcia de Mattos Barbosa, Richard J. Bram, Daniel Huynh, Cyra Kharas, Christine M. Bassis, Raif S. Geha, Juhi Katta, Marilia Cascalho, Adam R. Lefferts, Gabriel Núñez, Nobuhiko Kamada, Jeffrey L. Platt, Peter L. Freddolino, Christiane E. Wobus
Publikováno v:
JCI Insight.
TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223a2d55f6a80f1f4c53f8f706954368
https://doi.org/10.1172/jci.insight.148208
https://doi.org/10.1172/jci.insight.148208
Autor:
Raif S. Geha, Kharas C, Richard J. Bram, Daniel Huynh, Katta J, Marilia Cascalho, Nobuhiko Kamada, Adam R. Lefferts, de Mattos Barbosa Mg, Christiane E. Wobus, Christine M. Bassis, Jeffrey L. Platt, Peter L. Freddolino, Gabriel Núñez
TNFRSF13B encodes the “transmembrane-activator and CAML-interactor” (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051d465e8e797653f4da701b704c2313
https://doi.org/10.1101/2021.01.29.428850
https://doi.org/10.1101/2021.01.29.428850
Autor:
Kent Riemondy, Anjana Rao, Brian P. O'Connor, S. Harsha Krovi, Laurent Gapin, Adam R. Lefferts, Jay R. Hesselberth, Leonard L. Dragone, Catherine Halluszczak, Philippa Marrack, Jingjing Zhang, Lisa K. Peterson, Kathryn D. Tuttle, Laura Harmacek, James P. Scott-Browne, Romain Bedel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e4c35d3becfa75c6b45c62a82a633
http://link.springer.com/article/10.1038/s41467-018-05026-6
http://link.springer.com/article/10.1038/s41467-018-05026-6