Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adam Petrone"'
Autor:
Michal A. Stanczak, Natalia Rodrigues Mantuano, Nicole Kirchhammer, David E. Sanin, Francis Jacob, Ricardo Coelho, Arun V. Everest-Dass, Jinyu Wang, Marcel P. Trefny, Gianni Monaco, Anne Bärenwaldt, Melissa A. Gray, Adam Petrone, Abhishek S. Kashyap, Katharina Glatz, Benjamin Kasenda, Karl Normington, James Broderick, Li Peng, Oliver M.T. Pearce, Erika L. Pearce, Carolyn R. Bertozzi, Alfred Zippelius, Heinz Läubli
Publikováno v:
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with cancer, but the majority experiences limited benefit, supporting the need for new therapeutic approaches. Up-regulation of sialic acid–containing glycans, te
Autor:
Adam Petrone, Elia Aguado-Fraile, Sunantha Sethuraman, Adrienne Johnson, Ian Silverman, Gary Marshall, Jorge S. Reis-Filho, John Iafrate, Artur Veloso, Victoria Rimkunas
Publikováno v:
Cancer Research. 83:2132-2132
Amplification of CCNE1 is a recurrent genetic alteration that has been associated with chemoresistance and poor prognosis in gynecological malignancies. We identified Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) as a novel synthe
Autor:
Jimmy Fourtounis, John Martino, Rino Stocco, Prasamit Baruah, Nicole Duffy, David Gallo, Sarah Fournier, JingJing Li, Li Li, Elia Aguado, Adam Petrone, Anne Roulston, Yael Mamane, Stephen Morris, Janek Szychowski, Robert Papp, Mike Zinda, C. Gary Marshall
Publikováno v:
Cancer Research. 82:5650-5650
Cyclin E1, the protein product of the CCNE1 gene, complexes with CDK2 and is a key regulator of the G1-S transition in cycling cells. CCNE1 amplification has been associated with increased replication stress and genomic instability associated with tu
Publikováno v:
Cancer Immunology Research. 8:PR18-PR18
Cancer therapy has been revolutionized by inhibiting immune checkpoints to harness the power of the immune system in fighting cancer. However, the majority of patients are resistant to the current immuno-oncology drugs. There is a strong need to iden
Autor:
Benjamin Chittick, Daniel B. Graham, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Elizaveta S. Leshchiner, Virendar K. Kaushik, Zhifang Cao, Andrew J. Phillips, Michael A. Durney, Ramnik J. Xavier, Huixian Wu, Joshua A. Bittker, Jason S. Rush, Vlado Dančík, Mark J. Daly, Adam Petrone, Alykhan F. Shamji
Advances in human genetics have dramatically expanded our understanding of complex heritable diseases. Genome-wide association studies have identified an allelic series of CARD9 variants associated with increased risk of or protection from inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3de701edf206bec5b7e8f5faa106a3
https://europepmc.org/articles/PMC5664502/
https://europepmc.org/articles/PMC5664502/
Autor:
Cao Lizhi, Xu Lihui, Robert LeBlanc, Jeffrey Brown, Wei Yao, Michele Mayo, Peng Li, Michal A. Stanczak, Nerle Sujata, James Broderick, Karl Normington, Gatlin Wayne, Heinz Läubli, Zakir Siddiquee, Adam Petrone, Das Abhishek, Carolyn R. Bertozzi, Che Jenny
Publikováno v:
Cancer Research. 79:LB-109
Cancer therapy has been revolutionized by the recent developments of immune-checkpoint inhibitors (ICI) to harness the power of the immune system in fighting cancer. However, most patients fail to have durable responses or become resistant to ICI, hi
Autor:
Andrew J. Phillips, Adam Petrone, Daniel B. Graham, Alykhan F. Shamji, Huixian Wu, Thomas B. Sundberg, Stuart L. Schreiber, Isabel J. Latorre, Taebo Sim, Hwan Geun Choi, Ramnik J. Xavier, Nam Doo Kim, José Carlos Rodríguez Pérez, Bernard Khor, Liv Johannessen, Nathanael S. Gray, Yanke Liang
Publikováno v:
ACS chemical biology. 11(8)
Salt-inducible kinases (SIKs) are promising therapeutic targets for modulating cytokine responses during innate immune activation. The study of SIK inhibition in animal models of disease has been limited by the lack of selective small-molecule probes
Publikováno v:
Tetrahedron Letters. 52:5073-5076
The Barbier type allylation of carbonyl compounds is a useful organic transformation as the resultant homoallylic alcohols are important building blocks for many biologically active molecules. Tin mediated Barbier allylation of different carbonyl com
Publikováno v:
ChemInform. 43
The Barbier type allylation of carbonyl compounds is a useful organic transformation as the resultant homoallylic alcohols are important building blocks for many biologically active molecules. Tin mediated Barbier allylation of different carbonyl com