Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Adam P. Uldrich"'
Autor:
Catarina F. Almeida, Benjamin S. Gully, Claerwen M. Jones, Lukasz Kedzierski, Sachith D. Gunasinghe, Michael T. Rice, Richard Berry, Nicholas A. Gherardin, Trang T. Nguyen, Yee-Foong Mok, Josephine F. Reijneveld, D. Branch Moody, Ildiko Van Rhijn, Nicole L. La Gruta, Adam P. Uldrich, Jamie Rossjohn, Dale I. Godfrey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are a
Externí odkaz:
https://doaj.org/article/a4fb52352ddb44ba9d2176f3352758f0
Autor:
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with
Externí odkaz:
https://doaj.org/article/752fb81bb7254b64a74120356ca7f38e
Autor:
Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105259- (2022)
Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here,
Externí odkaz:
https://doaj.org/article/8d6f566f8f3c4f6d9a283613b3b50fb7
Autor:
Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose th
Externí odkaz:
https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142
Autor:
Hui-Fern Koay, Nicholas A. Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P. Fairlie, James McCluskey, Daniel G. Pellicci, Adam P. Uldrich, Dale I. Godfrey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are f
Externí odkaz:
https://doaj.org/article/1b1b3b4abd8747eea3ce8b9c98588996
Autor:
Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus
Externí odkaz:
https://doaj.org/article/19f35c34e90047c3a1089ce7f064778b
Autor:
Calvin Xu, Shihan Li, Thomas S Fulford, Susan N Christo, Laura K Mackay, Daniel HD Gray, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey, Hui-Fern Koay
Publikováno v:
Mucosal Immunology.
Autor:
Kirsty R. Field, Kathleen M. Wragg, Wen Shi Lee, Marc Rigau, Adam P. Uldrich, Stephen J. Kent, Jennifer A. Juno
Publikováno v:
European Journal of Immunology.
Autor:
null Kirsty R. Field, null Kathleen M. Wragg, null Wen Shi Lee, null Marc Rigau, null Adam P. Uldrich, null Stephen J. Kent, null Jennifer A. Juno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6858400666b887998976785925c839f
https://doi.org/10.1002/eji.202250220/v2/response1
https://doi.org/10.1002/eji.202250220/v2/response1
Publikováno v:
Trends in Immunology. 42:670-680
Vγ9Vδ2+ T cells form part of the innate immune repertoire and are activated by phosphorylated antigens produced by many bacteria and tumors. They have long been suggested as promising targets for anti-tumor therapies, but clinical trials so far hav