Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Adam P Patterson"'
Autor:
Abigail V. Sharrock, Jeff S. Mumm, Elsie M. Williams, Narimantas Čėnas, Jeff B. Smaill, Adam V. Patterson, David F. Ackerley, Gintautas Bagdžiūnas, Vickery L. Arcus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6593 (2024)
Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (E. coli NfsB F70A/F108Y) for
Externí odkaz:
https://doaj.org/article/35db6809fd4042d9882cc7c017640035
Autor:
Victoria Jackson-Patel, Emily Liu, Matthew R. Bull, Amir Ashoorzadeh, Gib Bogle, Anna Wolfram, Kevin O. Hicks, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under patholo
Externí odkaz:
https://doaj.org/article/c34ba5238adc4eb49a0ab52ce8b13172
Autor:
Linda Spiegelberg, Ruud Houben, Raymon Niemans, Dirk de Ruysscher, Ala Yaromina, Jan Theys, Christopher P. Guise, Jeffrey B. Smaill, Adam V. Patterson, Philippe Lambin, Ludwig J. Dubois
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 15, Iss , Pp 62-69 (2019)
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II results, the
Externí odkaz:
https://doaj.org/article/75c6748e20a543519df6ae43fdf0f2f0
Autor:
Amir Ashoorzadeh, Alexandra M. Mowday, Christopher P. Guise, Shevan Silva, Matthew R. Bull, Maria R. Abbattista, Janine N. Copp, Elsie M. Williams, David F. Ackerley, Adam V. Patterson, Jeff B. Smaill
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 185 (2022)
PR-104A is a dual hypoxia/nitroreductase gene therapy prodrug by virtue of its ability to undergo either one- or two-electron reduction to its cytotoxic species. It has been evaluated extensively in pre-clinical GDEPT studies, yet off-target human al
Externí odkaz:
https://doaj.org/article/9dcd35635dfd4a64b8e3fee16b54111f
Autor:
Maria R. Abbattista, Amir Ashoorzadeh, Christopher P. Guise, Alexandra M. Mowday, Rituparna Mittra, Shevan Silva, Kevin O. Hicks, Matthew R. Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A. Prosser, Neil K. Lambie, Gabi U. Dachs, David F. Ackerley, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1231 (2021)
PR-104 is a phosphate ester pre-prodrug that is converted in vivo to its cognate alcohol, PR-104A, a latent alkylator which forms potent cytotoxins upon bioreduction. Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which
Externí odkaz:
https://doaj.org/article/b19c86e2af6c49538c7e81a3e7b91af6
Autor:
Ziad Omran, Chris P. Guise, Linwei Chen, Cyril Rauch, Ashraf N. Abdalla, Omeima Abdullah, Ikhlas A. Sindi, Peter M. Fischer, Jeff B. Smaill, Adam V. Patterson, Yuxiu Liu, Qingmin Wang
Publikováno v:
Molecules, Vol 26, Iss 11, p 3327 (2021)
Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of Asclepiadaceas. They are characterized by interesting biological activities, such as pronounced cytotoxicity against diffe
Externí odkaz:
https://doaj.org/article/c9e24773f32e4df19e750c5e5c98a534
Publikováno v:
Cells, Vol 10, Iss 5, p 1006 (2021)
The magnitude of the host immune response can be regulated by either stimulatory or inhibitory immune checkpoint molecules. Receptor-ligand binding between inhibitory molecules is often exploited by tumours to suppress anti-tumour immune responses. I
Externí odkaz:
https://doaj.org/article/005f909081724a54accec5e2af897a59
Autor:
Chris P. Guise, Maria R. Abbattista, Robert F. Anderson, Dan Li, Rana Taghipouran, Angela Tsai, Su Jung Lee, Jeff B. Smaill, William A. Denny, Michael P. Hay, William R. Wilson, Kevin O. Hicks, Adam V. Patterson
Publikováno v:
Molecules, Vol 25, Iss 21, p 4888 (2020)
Hypoxia is an adverse prognostic feature of solid cancers that may be overcome with hypoxia-activated prodrugs (HAPs). Tirapazamine (TPZ) is a HAP which has undergone extensive clinical evaluation in this context and stimulated development of optimiz
Externí odkaz:
https://doaj.org/article/5febd59fbfbd4a7e9055143bd569de28
Autor:
Caitlin E Older, Alison Diesel, Adam P Patterson, Courtney Meason-Smith, Timothy J Johnson, Joanne Mansell, Jan S Suchodolski, Aline Rodrigues Hoffmann
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178555 (2017)
The skin is inhabited by a multitude of microorganisms. An imbalance of these microorganisms is associated with disease, however, the causal relationship between skin microbiota and disease remains unknown. To describe the cutaneous bacterial microbi
Externí odkaz:
https://doaj.org/article/55e2cd549a2b44228d67e18172c398ae
Publikováno v:
Molecules, Vol 14, Iss 11, Pp 4517-4545 (2009)
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to
Externí odkaz:
https://doaj.org/article/3b90ff071cfa4179ab022d6f78a0efe6