Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adam P Marcus"'
Autor:
Richa Sharma, Shagun Sharma, Pratik Shriwas, Labdhi Mehta, An H. Vu, Janna K. Mouw, Junghui Koo, Chunzi Huang, Veronika Y. Matsuk, Carol Tucker-Burden, Gregory Joseph, Madhusmita Behera, Shi-Yong Sun, Melissa A. Roy, Melissa Gilbert-Ross, Ticiana Leal, Adam I. Marcus, Mala Shanmugam
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111133- (2024)
Summary: Non-small cell lung cancer (NSCLC) collective invasion is supported by cooperativity of proliferative (follower) and invasive (leader) cells. H1299-isolated follower cells exhibit higher Yes-associated protein (YAP) expression, while leader
Externí odkaz:
https://doaj.org/article/1e28ac5e046f4e7e805bffe2f27cb0f5
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52472 (2012)
Translesion synthesis (TLS) provides a mechanism of copying damaged templates during DNA replication. This potentially mutagenic process may operate either at the replication fork or at post-replicative gaps. We used the example of T-T cyclobutane py
Externí odkaz:
https://doaj.org/article/c1d45c4373cd4473b07f306a92333905
Autor:
Christina M. Knippler, Jamie L. Arnst, Isaac E. Robinson, Veronika Matsuk, Tala O. Khatib, R. Donald Harvey, Mala Shanmugam, Janna K. Mouw, Haian Fu, Thota Ganesh, Adam I. Marcus
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109591- (2024)
Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-act
Externí odkaz:
https://doaj.org/article/23b5922f597f4f7084cf0f89ddff9f8a
Autor:
Tala O Khatib, Angelica M Amanso, Christina M Knippler, Brian Pedro, Emily R Summerbell, Najdat M Zohbi, Jessica M Konen, Janna K Mouw, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292554 (2023)
Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized
Externí odkaz:
https://doaj.org/article/fe27ed5d193243e1a74544f879fb7a81
Autor:
Jai Sidpra, Adam P Marcus, Ulrike Löbel, Sebastian M Toescu, Derek Yecies, Gerald Grant, Kristen Yeom, David M Mirsky, Hani J Marcus, Kristian Aquilina, Kshitij Mankad
Publikováno v:
Neuro-oncology advances. 4(1)
Background Postoperative pediatric cerebellar mutism syndrome (pCMS) is a common but severe complication that may arise following the resection of posterior fossa tumors in children. Two previous studies have aimed to preoperatively predict pCMS, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6789d5adc165fc225d6feb2dffb20023
https://pubmed.ncbi.nlm.nih.gov/35233531
https://pubmed.ncbi.nlm.nih.gov/35233531
Autor:
Jai Sidpra, Adam P Marcus, Ulrike Löbel, Sebastian Toescu, Derek Yecies, Gerald Grant, Kristen Yeom, David M Mirsky, Hani J Marcus, Kristian Aquilina, Kshitij Mankad
Publikováno v:
Neuro-Oncology. 24:i76-i77
BACKGROUND: Postoperative paediatric cerebellar mutism syndrome (pCMS) is a common but severe complication which may arise following the resection of posterior fossa tumours in children. Two previous studies have aimed to preoperatively predict pCMS,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222676374afeddd6976dd9c30cc164e1
https://doi.org/10.1093/neuonc/noac079.279
https://doi.org/10.1093/neuonc/noac079.279
Publikováno v:
Bioconjugate Chemistry; Dec2008, Vol. 19 Issue 12, p2559-2567, 9p
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Spheroid cultures derived from explanted cancer specimens are an increasingly utilized resource for studying complex biological processes like tumor cell invasion and metastasis, representing an important bridge between the simplicity and pr
Externí odkaz:
https://doaj.org/article/8098aaddc24a4afebe20581829e7721b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 5, p e1006131 (2018)
Many tumors are characterized by genetic instability, producing an assortment of genetic variants of tumor cells called subclones. These tumors and their surrounding environments form complex multi-cellular ecosystems, where subclones compete for res
Externí odkaz:
https://doaj.org/article/c58b7352d59a494ea4a5dd733b38b2ba
Autor:
Zhen Yang, Anapatricia Garcia, Songli Xu, Doris R Powell, Paula M Vertino, Shivendra Singh, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75069 (2013)
Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastat
Externí odkaz:
https://doaj.org/article/a7742008364146ddb1b746a5a5b08b69