Výsledky vyhledávání - "Adam Přibylka"

The Assignment of the Absolute Configuration of β-Chiral Primary Alcohols with Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid

Autor: Adam Přibylka, Petr Cankař, David Profous, Michal Kriegelstein

Publikováno v: The Journal of Organic Chemistry. 85:12912-12921

Axially chiral trifluoromethylbenzimidazolylbenzoic acid (TBBA) was used as a chiral derivatization agent for the assignment of the absolute configuration of β-chiral primary alcohols. The structures varied from simple aliphatic alcohols to complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e819eea226b3a5e9a2946c3e942d00f
https://doi.org/10.1021/acs.joc.0c01510

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Greening Solid-Phase Organic Synthesis: Environmentally Conscious Synthesis of Pharmaceutically Relevant Privileged Structures 5,6-Dihydropyridin-2(1H)-ones and Quinolin-2(1H)-ones

Autor: Viktor Krchňák, Eva Schütznerová, Noelia S. Medran, Adam Přibylka

Publikováno v: The Journal of Organic Chemistry. 85:11867-11881

Solid-phase organic synthesis (SPOS) is a very efficient methodology for the synthesis of diverse organic molecules, particularly exploited in drug discovery. Here, we present the transformation of...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::595876ddf22e67483c2b0a3df9d53986
https://doi.org/10.1021/acs.joc.0c01623

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Environmentally friendly SPPS I. Application of NaOH in 2-MeTHF/methanol for Fmoc removal

Autor: Eva Schütznerová, Adam Přibylka, Viktor Krchňák

Publikováno v: Green Chemistry. 21:775-779

Focusing on the step-by-step transformation of the traditional solid-phase peptide synthesis (SPPS) into an environmentally friendly process, we herein report the elimination of environmentally hazardous components (piperidine, DMF and DCM) from this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cca905f831a7bde7a71194d8103ce40
https://doi.org/10.1039/c8gc03778g

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Environmentally Friendly SPPS II: Scope of Green Fmoc Removal Protocol Using NaOH and Its Application for Synthesis of Commercial Drug Triptorelin

Autor: Eva Schütznerová, Viktor Krchňák, Adam Přibylka

Publikováno v: The Journal of organic chemistry. 85(14)

With the growing necessity to consider environmental impacts when synthesizing peptide-based drugs and to expand upon the recently published short communication report, we herein present a thorough evaluation of a green Fmoc removal protocol. Our pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f3b7a35c16d6d8b7edd9ff53f0706c
https://pubmed.ncbi.nlm.nih.gov/32519543

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Nα-Amino acid containing privileged structures: design, synthesis and use in solid-phase peptide synthesis

Autor: Viktor Krchňák, Eva Schütznerová, Adam Přibylka

Publikováno v: Organic & Biomolecular Chemistry. 16:5359-5362

Fmoc-protected Nα-amino acid containing heterocyclic privileged structures, O-(1-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)-l-serine and O-((S)-5-oxo-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)-l-serine, were synthesized on the solid phase from simple com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4550fb00eae96e789b3784d71a4b56f
https://doi.org/10.1039/c8ob01485j

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The application of anisole in greener solid-phase peptide synthesis protocols – Compatibility with green bases in Fmoc removal and new green binary mixture for coupling

Autor: Adam Přibylka, Eva Schütznerová, Martin Grepl, Milan Pastorek

Publikováno v: Tetrahedron. 99:132452

As a step toward green Fmoc solid-phase peptide synthesis (SPPS), we explored the compatibility of the green bases morpholine, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and NaOH with the green solvent anisole as a replacement for the traditionally use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b89ea8cdde4d5e3f2802fb0752cef8b
https://doi.org/10.1016/j.tet.2021.132452

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Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid: A Chiral Derivatizing Agent for α-Chiral Primary Amines and Secondary Alcohols To Determine the Absolute Configuration

Autor: Sandra Benická, Michal Kriegelstein, Adam Přibylka, Antonín Lyčka, David Profous, Tereza Volná, Zdeněk Trávníček, Petr Cankař

Publikováno v: The Journal of organic chemistry. 84(18)

Racemic 2-(2-trifluoromethyl)-1H-benzo[d]imidazol-1-yl)benzoic acid (TBBA) was synthesized in three steps from 1-fluoro-2-nitrobenzene. Target (P)- and (M)-TBBA atropisomers were stable with a racemization barrier above 30 kcal/mol. As a chiral deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea701483fc7d9f0472915898d11a683c
https://pubmed.ncbi.nlm.nih.gov/31449414

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Enantioseparation of d,l-2-hydroxyglutaric acid by capillary electrophoresis with tandem mass spectrometry—Fast and efficient tool for d- and l-2-hydroxyglutaracidurias diagnosis

Autor: Adam Přibylka, Martin Švidrnoch, Vratislav Smolka, Vojtěch Bekárek, Vítězslav Maier, Juraj Ševčík

Publikováno v: Journal of Chromatography A. 1467:383-390

A novel capillary electrophoresis–tandem mass spectrometry method for the enantioseparation and identification of 2-hydroxyglutaric acid enantiomers without derivatization for clinical purposes was described. Vancomycin chloride was used as an effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350da81c63fd6c70371b7eddc0717e0a
https://doi.org/10.1016/j.chroma.2016.05.095

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