Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adam Oberstein"'
Publikováno v:
Viruses, Vol 16, Iss 1, p 49 (2023)
Human cytomegalovirus (HCMV) has a broad cellular tropism and epithelial cells are important physiological targets during infection. The retinal pigment epithelial cell line ARPE-19 has been used to model HCMV infection in epithelial cells for decade
Externí odkaz:
https://doaj.org/article/de3a8a70014e4248934ceab0138596ed
Autor:
Maciej T. Nogalski, Alexander Solovyov, Anupriya S. Kulkarni, Niyati Desai, Adam Oberstein, Arnold J. Levine, David T. Ting, Thomas Shenk, Benjamin D. Greenbaum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affec
Externí odkaz:
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
Autor:
Jihye Park, Kevin Sean Gill, Ali Asghar Aghajani, Jeremiah Dallas Heredia, Hannah Choi, Adam Oberstein, Erik Procko
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008647 (2020)
A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα poten
Externí odkaz:
https://doaj.org/article/4e5648466d92460796e2f22e32c6f476
Autor:
Niyati Desai, Maciej T. Nogalski, Alexander Solovyov, David T. Ting, Arnold J. Levine, Benjamin Greenbaum, Adam Oberstein, Anupriya S. Kulkarni, Thomas Shenk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706c4dc56cec6fef3d12c50c2d2b1afe
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(42)
Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in fibroblasts and a pentameric complex (gH/gL/pUL128-pUL130-pUL131A) that medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7c901a02a2f6161b7e429c83798013
https://pubmed.ncbi.nlm.nih.gov/30275317
https://pubmed.ncbi.nlm.nih.gov/30275317
Autor:
Todd M. Greco, Adam Oberstein, Yibin Kang, Rommel A. Mathias, Ileana M. Cristea, Rumela Chakrabarti, Hanna G. Budayeva, Elizabeth A. Rowland, Thomas Shenk
Publikováno v:
Cell. 159(7):1615-1625
SummarySirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d96603deb3919674457450d3aef47
Autor:
Adam Oberstein, Thomas Shenk
Human cytomegalovirus (HCMV) is the prototypical human β-herpes virus. Here we perform a systems analysis of the HCMV host-cell transcriptome, using gene set enrichment analysis (GSEA) as an engine to globally map the host-pathogen interaction acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076c8b25ba92b4fd7309e76a82a6ae8f
https://europepmc.org/articles/PMC5625929/
https://europepmc.org/articles/PMC5625929/
Publikováno v:
Journal of Biological Chemistry. 282:13123-13132
Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2b2dae2fb066a960fb2ae769c3cdb8
https://doi.org/10.1074/jbc.m700492200
https://doi.org/10.1074/jbc.m700492200
Replication of human cytomegalovirus is regulated in part by cellular kinases and the single viral Ser/Thr kinase, pUL97. The virus-coded kinase augments the replication of human cytomegalovirus (HCMV) by enabling nuclear egress and altering cell cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be745ed8da723f74f3d30cf16034984
https://europepmc.org/articles/PMC4522931/
https://europepmc.org/articles/PMC4522931/
Publikováno v:
Developmental Biology. 276:541-551
The Drosophila body plan is composed of a linear array of cephalic, thoracic, and abdominal segments along the anterior posterior axis. The number and positions of individual segments are established by a transcriptional network comprised of maternal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed2e1f6a5db40782cddabf3bf61a864
https://doi.org/10.1016/j.ydbio.2004.09.025
https://doi.org/10.1016/j.ydbio.2004.09.025