Výsledky vyhledávání - "Adam O. Shea"

Data from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223 dichloride, 223RaCl2), has stimulated significant interest in the development of new alpha-particle emitting drugs in oncology. Unlike radium-223 (223Ra), the parent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e35ca4b99143e9db09cefc4dfb3643
https://doi.org/10.1158/1535-7163.c.6537598.v1

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Supplementary Figure S3. Analysis of white blood cell and red blood cell counts from disseminated xenograft model. from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

Blood samples from animals treated with vehicle and CD33-TTC, administered at the different dose levels, were taken at Day -1, Day 67 and Day 123. (A) White blood cell counts, expressed in 109/L. (B) Red blood cell counts, expressed in 1012/L.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e61add3f7aa0bbca94cc30520932a5
https://doi.org/10.1158/1535-7163.22504039.v1

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Supplementary Figures from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

Supplementary figure legends.

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https://doi.org/10.1158/1535-7163.22504033

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Supplementary Figure S1. Decay chain of thorium-227. from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

Thorium-227 is purified from actinium-227 (227Ac). Thorium-227 decays via its alpha- and beta-emitting daughters to stable nonradioactive 207Pb. The energy emitted at each decay step (in MeV) are summarized. When thorium-227 decays to radium-223, the

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https://doi.org/10.1158/1535-7163.22504045

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Supplementary Figure S4. Evaluation of disease state in vehicle control treated animals by IHC. from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

Isolated kidneys (A, B) and bone marrow (C, D) were co-stained with a CD33-specific antibody (A, C) and a CD45-specific antibody (B, D).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fb2fc7d4c3690db8486abc7ecb072
https://doi.org/10.1158/1535-7163.22504036

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Supplementary Figure S2. Flow cytometry analysis of CD33 antibody and CD33 antibody-chelator conjugate to HL-60 cells. from In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann

Binding of CD33 antibody and CD33 antibody chelator-conjugate to CD33-positive HL-60 cells by FACS staining in comparison to an isotype control. Bound antibodies were detected using secondary PE-labeled anti-human antibody. Median fluorescence intens

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https://doi.org/10.1158/1535-7163.22504042

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In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

Autor: Kristine Sponheim, Jenny Karlsson, Katrine Wickstroem, Ellen Wang, Adam O. Shea, Urs B. Hagemann, Alan Cuthbertson, Roger M. Bjerke, Olav B. Ryan

Publikováno v: Molecular Cancer Therapeutics. 15:2422-2431

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https://doi.org/10.1158/1535-7163.mct-16-0251

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