Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Adam Naguib"'
Autor:
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 58-67 (2018)
Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference. Highly se
Externí odkaz:
https://doaj.org/article/ef92114328e64222bc2c836f7460a8f4
Autor:
Adam Naguib, Gyula Bencze, Dannielle D. Engle, Iok I.C. Chio, Tali Herzka, Kaitlin Watrud, Szilvia Bencze, David A. Tuveson, Darryl J. Pappin, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 10, Iss 1, Pp 8-19 (2015)
Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal transduction system that is deregulated in cancer. In stark contrast to PIP inositol head-group
Externí odkaz:
https://doaj.org/article/53b18fd79ede4d1d8913e6ee1a3bf047
Publikováno v:
Cell reports. 26(1)
Summary SUPT4H1 is a transcription elongation factor that makes up part of the RNA polymerase II complex. Recent studies propose a selective role for SUPT4H1 in the transcription of repeat-containing DNA, the translated products of which contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b03666895b948d2895b81d3859653f
https://pubmed.ncbi.nlm.nih.gov/30605685
https://pubmed.ncbi.nlm.nih.gov/30605685
Autor:
Chio, Szilvia Bencze, Lloyd C. Trotman, Dannielle D. Engle, Kaitlin Watrud, David A. Tuveson, Adam Naguib, Gyula Bencze, Darryl J. Pappin, Tali Herzka
Publikováno v:
Cell Reports, Vol 10, Iss 1, Pp 8-19 (2015)
SummaryPhosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal transduction system that is deregulated in cancer. In stark contrast to PIP inositol head
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9d404459804c0f7a95b701d5cf507
Autor:
Adam Naguib
Publikováno v:
Science Signaling. 9
Gloss Lipids can serve as cellular signaling molecules. Phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] is one such lipid that is the key molecular product of the pathway involving phosphoinositide 3-kinase (PI3K), which synthesizes PtdI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c1554411e5a66cc8868b381de24bb8
https://doi.org/10.1126/scisignal.aad7885
https://doi.org/10.1126/scisignal.aad7885
Autor:
Richard Bowman, Richard Y. Ball, James C Cooke, Philip A. Burns, Jennifer Keen, Robert Luben, Panagiota N. Mitrou, Adam Naguib, Marleen A. H. Lentjes, Mark J. Arends, Kay-Tee Khaw, Gunter G. C. Kuhnle, Ashraf E.K. Ibrahim
Publikováno v:
The Journal of Pathology. 228:405-415
The tumour suppressor APC is the most commonly altered gene in colorectal cancer (CRC). Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC. Analysis of APC mutations in the extended m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a784ec3960ce2a021090b7285bbdb527
https://doi.org/10.1002/path.4085
https://doi.org/10.1002/path.4085
Autor:
Wu Zheng, Ante Tocilj, Nadia Jaber, Christopher R. Faehnle, Lloyd C. Trotman, Muhan Chen, Michael S. Marks, Wei-Xing Zong, Hyejin Cho, Gyula Bencze, Leemor Joshua-Tor, Elad Elkayam, Adam Naguib, Christopher P. Pratt, Darryl J. Pappin
Publikováno v:
Molecular cell. 58(2)
PTEN is proposed to function at the plasma membrane, where receptor tyrosine kinases are activated. However, the majority of PTEN is located throughout the cytoplasm. Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a40cc7b53667adf01e5af31f3c0da1
https://pubmed.ncbi.nlm.nih.gov/26017306
https://pubmed.ncbi.nlm.nih.gov/26017306
Autor:
Adam Naguib, Lloyd C. Trotman
Publikováno v:
Trends in cell biology. 23(8)
PTEN loss drives many cancers and recent genetic studies reveal that often PTEN is antagonised at the protein level without alteration of DNA or RNA expression. This scenario can already cause malignancy since PTEN is haploinsufficient. We here revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822c7c94cb43f8e5153c9c18d6be4080
https://pubmed.ncbi.nlm.nih.gov/23578748
https://pubmed.ncbi.nlm.nih.gov/23578748
Autor:
Laura J, Gay, Panagiota N, Mitrou, Jennifer, Keen, Richard, Bowman, Adam, Naguib, James, Cooke, Gunter G, Kuhnle, Philip A, Burns, Robert, Luben, Marleen, Lentjes, Kay-Tee, Khaw, Richard Y, Ball, Ashraf Ek, Ibrahim, Mark J, Arends
Publikováno v:
The Journal of pathology. 228(3)
The tumour suppressor APC is the most commonly altered gene in colorectal cancer (CRC). Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors for CRC. Analysis of APC mutations in the extended m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::518d3e8272f042bf03a9618c19092be9
https://pubmed.ncbi.nlm.nih.gov/22864938
https://pubmed.ncbi.nlm.nih.gov/22864938
Autor:
Lloyd C. Trotman, Adam Naguib, Matthew Dixon, John Silke, Perry F. Bartlett, Alison Macintyre, Tim Thomas, Vicki E. Hammond, Ulrich Putz, Jennifer K. Callaway, Jenny Lackovic, Baoli Yang, Ley-Hian Low, Sharad Kumar, Jason Howitt, Seong-Seng Tan, Choo-Peng Goh
Publikováno v:
The Journal of Cell Biology
PTEN nuclear entry driven by ubiquitination is mediated by the ligase-interacting protein Ndfip1 and is essential for neuronal survival in mice after cerebral ischemia.
PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the maj
PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c901e2e9bc91fa1b729e73ac3d7bee7
https://hdl.handle.net/1959.8/155251
https://hdl.handle.net/1959.8/155251
