Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Adam M. Spivak"'
Autor:
Tiffany F. Ho, Brian Zenger, Bayarmaa Mark, Laurel Hiatt, Erika Sullivan, Benjamin A. Steinberg, Ann Lyons, Adam M. Spivak, Cori Agarwal, Marisa Adelman, James Hotaling, Bernadette Kiraly, Sharon Talboys
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/c21bb4d3a4104e309ac97e47d5d93e96
Autor:
Eugene V. Ravkov, Elizabeth S. C. P. Williams, Marc Elgort, Adam P. Barker, Vicente Planelles, Adam M. Spivak, Julio C. Delgado, Leo Lin, Timothy M. Hanley
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe clinical manifestations of acute severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) suggest a dysregulation of the host immune response that leads to inflammation, throm
Externí odkaz:
https://doaj.org/article/c52ac4d8929e452ab412db6de5ac603e
Autor:
Oriol Mitjà, Gilmar Reis, David R. Boulware, Adam M. Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D. Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C. Lee, Katherine Huppler Hullsiek, Emily G. McDonald, Rachel Hess, Michael Hughes, Jared M. Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W. Chew, Eric Daar, David Wohl, Michael Dunne
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 524-535 (2023)
Abstract Hydroxychloroquine (HCQ) was initially promoted as an oral therapy for early treatment of coronavirus disease 2019 (COVID‐19). Conventional meta‐analyses cannot fully address the heterogeneity of different designs and outcomes of randomi
Externí odkaz:
https://doaj.org/article/2f0332ecf5a2428ebd4d3c3b0d83894f
Autor:
Vanessa Redecke, Kazuki Tawaratsumida, Erin T. Larragoite, Elizabeth S. C. P. Williams, Vicente Planelles, Adam M. Spivak, Lincoln Hirayama, Marc Elgort, Shane Swenson, Rick Smith, Bryan Worthen, Russ Zimmerman, Patricia Slev, Ben Cahoon, Mark Astill, Hans Häcker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Diagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard
Externí odkaz:
https://doaj.org/article/1655f619167244489c5e59a7785e3869
Autor:
Yue Zheng, Erin T. Larragoite, Elizabeth S. C. P. Williams, Juan Lama, Isabel Cisneros, Julio C. Delgado, Patricia Slev, Jenna Rychert, Emily A. Innis, Mayte Coiras, Matthew T. Rondina, Adam M. Spivak, Vicente Planelles
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-6 (2021)
Abstract Background Virus neutralization by antibodies is an important prognostic factor in many viral diseases. To easily and rapidly measure titers of neutralizing antibodies in serum or plasma, we developed pseudovirion particles composed of the s
Externí odkaz:
https://doaj.org/article/23bf90048a4649b098183e1247d1a8c6
Autor:
Emily Cruz-Lorenzo, Nora-Guadalupe P. Ramirez, Jeon Lee, Sonali Pandhe, Lei Wang, Juan Hernandez-Doria, Adam M. Spivak, Vicente Planelles, Tianna Petersen, Mamta K. Jain, Elisabeth D. Martinez, Iván D’Orso
Publikováno v:
Viruses, Vol 14, Iss 10, p 2288 (2022)
Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding. Here, using a screen approach on CD4+ T cell models of HIV-1 latency, we revealed Small Molecule R
Externí odkaz:
https://doaj.org/article/c7a4d40bbedc40dd9dbcbd1dc2a1f3a3
Autor:
Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The mitochondrial antiviral signaling protein (MAVS) is part of the cell’s innate immune mechanism of defense. MAVS mRNA is bicistronic and can give rise to a full length-MAVS and a shorter isoform termed miniMAVS. In response to viral infections,
Externí odkaz:
https://doaj.org/article/2d9d89e2d68d41a7894a9b45ae46dc68
Autor:
Daniel B. Reeves, Elizabeth R. Duke, Thor A. Wagner, Sarah E. Palmer, Adam M. Spivak, Joshua T. Schiffer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generate
Externí odkaz:
https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0
Autor:
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)
Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induc
Externí odkaz:
https://doaj.org/article/844b2284d4654ae7b526e217e79fb151
Autor:
Yu-Chi Tsai, Racheal A. Nell, Jonathan E. Buckendorf, Norbert Kúsz, Peter Waweru Mwangi, Róbert Berkecz, Dóra Rédei, Andrea Vasas, Adam M. Spivak, Judit Hohmann
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 653 (2021)
Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated. A variety of compounds isolated from Euphorbia species ha
Externí odkaz:
https://doaj.org/article/e23372ff63244118a4209bcf19f4045d