Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Adam M. Sonabend"'
Autor:
Víctor A. Arrieta, Andrew Gould, Kwang-Soo Kim, Karl J. Habashy, Crismita Dmello, Gustavo I. Vázquez-Cervantes, Irina Palacín-Aliana, Graysen McManus, Christina Amidei, Cristal Gomez, Silpol Dhiantravan, Li Chen, Daniel Y. Zhang, Ruth Saganty, Meghan E. Cholak, Surya Pandey, Matthew McCord, Kathleen McCortney, Brandyn Castro, Rachel Ward, Miguel Muzzio, Guillaume Bouchoux, Carole Desseaux, Michael Canney, Alexandre Carpentier, Bin Zhang, Jason M. Miska, Maciej S. Lesniak, Craig M. Horbinski, Rimas V. Lukas, Roger Stupp, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbub
Externí odkaz:
https://doaj.org/article/79679c002d644430b29884550815aa26
Publikováno v:
Biologics, Vol 4, Iss 2, Pp 161-176 (2024)
Traumatic Brain Injury (TBI) is a debilitating condition that poses a significant public health concern. Historically linked to motor vehicle accidents, the epidemiology of TBI has evolved. Falls now emerge as the predominant cause, particularly amon
Externí odkaz:
https://doaj.org/article/75663a668b13416c91d41cc62d7e0ca4
Autor:
Alexandre Carpentier, Roger Stupp, Adam M. Sonabend, Henry Dufour, Olivier Chinot, Bertrand Mathon, François Ducray, Jacques Guyotat, Nathalie Baize, Philippe Menei, John de Groot, Jeffrey S. Weinberg, Benjamin P. Liu, Eric Guemas, Carole Desseaux, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Ahmed Idbaih
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are repo
Externí odkaz:
https://doaj.org/article/e712a20f4c934b6c8309df6f0e891005
Autor:
David Hou, Hanxiao Wan, Joshua L. Katz, Si Wang, Brandyn A. Castro, Gustavo I. Vazquez-Cervantes, Victor A. Arrieta, Silpol Dhiantravan, Hinda Najem, Aida Rashidi, Tzu-yi Chia, Tarlan Arjmandi, Jimena Collado, Leah Billingham, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Amy B. Heimberger, Peng Zhang, Jason Miska, Catalina Lee-Chang
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells
Externí odkaz:
https://doaj.org/article/6ecf574030ed40ef851a4a0c31efda84
Autor:
Peng Zhang, Aida Rashidi, Junfei Zhao, Caylee Silvers, Hanxiang Wang, Brandyn Castro, Abby Ellingwood, Yu Han, Aurora Lopez-Rosas, Markella Zannikou, Crismita Dmello, Rebecca Levine, Ting Xiao, Alex Cordero, Adam M. Sonabend, Irina V. Balyasnikova, Catalina Lee-Chang, Jason Miska, Maciej S. Lesniak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Glioblastoma is an immunologically cold tumour, with poor CD8 + T cell infiltration and enrichment in immunosuppressive tumour-associated myeloid cells. Here, the authors generate a bispecific lipid nanoparticle targeting CD47 and PD-L1, combined wit
Externí odkaz:
https://doaj.org/article/70608dccfdaf43fd8925f863fd3fe044
Autor:
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Victor A. Arrieta, Daniel Y. Zhang, Kwang-Soo Kim, Deepak Kanojia, Peng Zhang, Jason Miska, Ragini Yeeravalli, Karl Habashy, Ruth Saganty, Seong Jae Kang, Jawad Fares, Connor Liu, Gavin Dunn, Elizabeth Bartom, Matthew J. Schipma, Patrick D. Hsu, Mahmoud S. Alghamri, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Immunotherapies have shown limited efficacy in patients with glioma. Here, based on an in vivo kinome knockout CRISPR screen, the authors show that checkpoint kinase 2 promotes CD8 T cell immune evasion and that its depletion or inhibition improve su
Externí odkaz:
https://doaj.org/article/add0ff19941e4f458a8e86e32cf2095c
Autor:
Surya Pandey, Meghan E. Cholak, Rishita Yadali, Jeffrey A. Sosman, Marie-Pier Tetreault, Deyu Fang, Seth M. Pollack, Sacha Gnjatic, Rebecca C. Obeng, H. Kim Lyerly, Adam M. Sonabend, José A. Guevara-Patiño, Lisa H. Butterfield, Bin Zhang, Holden T. Maecker, I. Caroline Le Poole
Publikováno v:
Cancers, Vol 16, Iss 3, p 475 (2024)
As part of a symposium, current and former directors of Immune Monitoring cores and investigative oncologists presented insights into the past, present and future of immune assessment. Dr. Gnjatic presented a classification of immune monitoring techn
Externí odkaz:
https://doaj.org/article/7402fd7fa9c0421399dc6aa703afec4f
Autor:
Víctor A. Arrieta, Crismita Dmello, Daniel J. McGrail, Daniel J. Brat, Catalina Lee-Chang, Amy B. Heimberger, Dhan Chand, Roger Stupp, Adam M. Sonabend
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show that subsets of patients with glioma exhibit durable responses to immunotherapy, the effica
Externí odkaz:
https://doaj.org/article/e5116efe28b640fab150259dd932a2e9
Autor:
Collin J. Larkin, Víctor A. Arrieta, Hinda Najem, Gongbo Li, Peng Zhang, Jason Miska, Peiwen Chen, Charles David James, Adam M. Sonabend, Amy B. Heimberger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors. Single cell analysis techniques such as single ce
Externí odkaz:
https://doaj.org/article/91cd612427b341e3acf22d05b23a71a7
Autor:
Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel Verhaak, Anand Shankar, Santhoshi N. Krishnan, Frederick S. Varn, Víctor A. Arrieta, Pravesh Gupta, Sherise D. Ferguson, Jason T. Huse, Gregory N. Fuller, James P. Long, Daniel E. Winkowski, Ben A. Freiberg, Charles David James, Leonidas C. Platanias, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
BACKGROUND Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.METHODS En bloc resections of gliomas (n = 10) and lung metastases (n = 10) w
Externí odkaz:
https://doaj.org/article/ee2104f14ae1491f89501b1b618cfbda