Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adam M. Heck"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Yoon Jung Choi, Adam M. Heck, Brian J. Hayes, Daniel Lih, Samuel G. Rayner, Brandon Hadland, Ying Zheng
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonst
Externí odkaz:
https://doaj.org/article/7f8f2a25dadc43d59ce34ae1926483f8
Autor:
Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109675- (2021)
Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyelo
Externí odkaz:
https://doaj.org/article/aeadf5874656435cb00af40d81bd981a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
During embryonic development, sequential waves of hematopoiesis give rise to blood-forming cells with diverse lineage potentials and self-renewal properties. This process must accomplish two important yet divergent goals: the rapid generation of diff
Externí odkaz:
https://doaj.org/article/6b616d1b4ce04b6c8f584f54a543341d
Autor:
Joseph Russo, Jerome E Lee, Carolina M López, John Anderson, Thuy-Mi P Nguyen, Adam M Heck, Jeffrey Wilusz, Carol J Wilusz
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170680 (2017)
We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. Through immunoprecipitation of RNAs cross
Externí odkaz:
https://doaj.org/article/e0a3b8c5c2f442b18b970ccd7093527c
Autor:
Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Blood. 140:8574-8575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14271786781ee1c6cd2bd5c03764d06
https://doi.org/10.1182/blood-2022-156513
https://doi.org/10.1182/blood-2022-156513
Publikováno v:
RNA. 26:739-755
N6-methyladenosine (m6A) is an abundant post-transcriptional modification that can impact RNA fate via interactions with m6A-specific RNA binding proteins. Despite accumulating evidence that m6A plays an important role in modulating pluripotency, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd564cbd86e0f88ba91757a5adceab5
https://doi.org/10.1261/rna.073502.119
https://doi.org/10.1261/rna.073502.119
Autor:
Samuel G. Rayner, Brian Hayes, Yoon Jung Choi, Adam M Heck, Brandon Hadland, Ying Zheng, Daniel Lih
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bb5d48501b5335012f214f43e6c15e
https://doi.org/10.1186/s13287-021-02380-z
https://doi.org/10.1186/s13287-021-02380-z
Autor:
Sanjay Srivatsan, Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Dana Jackson, Brandon Hadland, Shahin Rafii, Cole Trapnell, Adam M Heck, Tessa Dignum, Olivia Waltner, Irwin D. Bernstein, Stacey Dozono
SUMMARYDuring embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a84988cc0099f0305022ac79db16f9f
https://doi.org/10.1101/2021.04.13.439736
https://doi.org/10.1101/2021.04.13.439736
Autor:
Shahin Rafii, Stacey Dozono, Brandon Hadland, Cole Trapnell, Barbara Varnum-Finney, Irwin D. Bernstein, Adam M Heck, Olivia Waltner, Dana Jackson, Sanjay Srivastan, Cynthia Nourigat-Mckay, Tessa Dignum
Publikováno v:
SSRN Electronic Journal.
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid progeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a983a6cd501aefb1318701a1307a58
https://doi.org/10.2139/ssrn.3832990
https://doi.org/10.2139/ssrn.3832990