Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Adam M. Farkas"'
Autor:
Casandra Panea, Adam M. Farkas, Yoshiyuki Goto, Shahla Abdollahi-Roodsaz, Carolyn Lee, Balázs Koscsó, Kavitha Gowda, Tobias M. Hohl, Milena Bogunovic, Ivaylo I. Ivanov
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1314-1324 (2015)
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrat
Externí odkaz:
https://doaj.org/article/25d7a25159a54385952a2286e56e880e
Autor:
Nina Bhardwaj, Seunghee Kim-Schulze, Matthew Galsky, John Sfakianos, Amir Horowitz, Kristin Beaumont, Michelle A Tran, Adam M Farkas, Dina Youssef
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b011823130a54943ae6c3de5d896f403
Autor:
Matthew D. Park, Ivan Reyes-Torres, Jessica LeBerichel, Pauline Hamon, Nelson M. LaMarche, Samarth Hegde, Meriem Belabed, Leanna Troncoso, John A. Grout, Assaf Magen, Etienne Humblin, Achuth Nair, Martina Molgora, Jinchao Hou, Jenna H. Newman, Adam M. Farkas, Andrew M. Leader, Travis Dawson, Darwin D’Souza, Steven Hamel, Alfonso Rodriguez Sanchez-Paulete, Barbara Maier, Nina Bhardwaj, Jerome C. Martin, Alice O. Kamphorst, Ephraim Kenigsberg, Maria Casanova-Acebes, Amir Horowitz, Brian D. Brown, Lucas Ferrari De Andrade, Marco Colonna, Thomas U. Marron, Miriam Merad
Publikováno v:
Nature Immunology. 24:792-801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03bc3b9e8d3d3b64cd6944d3408171bd
https://doi.org/10.1038/s41590-023-01475-4
https://doi.org/10.1038/s41590-023-01475-4
Autor:
David J. Mulholland, Jun Zhu, Nina Bhardwaj, Adam M. Farkas, Bishoy M. Faltas, Olivier Elemento, Harkirat S. Sandhu, Matthew D. Galsky, Jorge Daza, Yang Hu, Li Wang, John P. Sfakianos, Haocheng Yu
Supplementary Data from Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT–Stromal and Tgfβ-Dependent Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b6af0119484ccf6a76fcaacd92674a
https://doi.org/10.1158/1535-7163.22523731.v1
https://doi.org/10.1158/1535-7163.22523731.v1
Autor:
Matthew D. Galsky, Jun Zhu, Nina Bhardwaj, Padmanee Sharma, Eric Schadt, Xin Yao, Keziban Unsal-Kacmaz, Megan Wind-Rotolo, Peter M. Szabo, William K. Oh, Peter Wiklund, Sudeh Izadmehr, Austin Hake, Sacha Gnjatic, Adam M. Farkas, Robert P. Sebra, Amir Horowitz, Guray Akturk, Kristin G. Beaumont, John P. Sfakianos, Li Wang
Purpose:To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer.Experimental Design:We pursued an unbiased approach using bulk RNA sequencing data from two clinical trials to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172a51184276f191649cafbed4713694
https://doi.org/10.1158/1078-0432.c.6530757.v1
https://doi.org/10.1158/1078-0432.c.6530757.v1
Autor:
Ashley, Reid Cahn, Adam M, Farkas
Publikováno v:
Nature reviews. ImmunologyOriginal articleRelated article. 22(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::008ec818f940bd1703e5a304710f9853
https://pubmed.ncbi.nlm.nih.gov/35869322
https://pubmed.ncbi.nlm.nih.gov/35869322
Autor:
Sacha Gnjatic, Adam M. Farkas, Matthew D. Galsky, Xin Yao, Sudeh Izadmehr, Eric E. Schadt, Robert Sebra, Péter Szabó, Li Wang, Austin Hake, Padmanee Sharma, Guray Akturk, Nina Bhardwaj, John P. Sfakianos, Kristin G. Beaumont, Megan Wind-Rotolo, Peter Wiklund, Jun Zhu, William Oh, Keziban Unsal-Kacmaz, Amir Horowitz
Publikováno v:
Clin Cancer Res
Purpose: To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer. Experimental Design: We pursued an unbiased approach using bulk RNA sequencing data from two clinical trials t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cec528e85fb44f98f3c55d7070060c
https://doi.org/10.1158/1078-0432.ccr-20-4574
https://doi.org/10.1158/1078-0432.ccr-20-4574
Autor:
Bérengère Salomé, John P. Sfakianos, Jorge Daza, Andrew Charap, Christian Hammer, Romain Banchereau, Adam M. Farkas, Daniel Geanon, Geoffrey Kelly, Ronaldo M. de Real, Brian Lee, Kristin G. Beaumont, Sanjana Shroff, Yuan Shuo A. Wang, Ying-chih Wang, Tin Htwe Thin, Monica Garcia-Barros, Everardo Hegewisch-Solloa, Emily M. Mace, Li Wang, Timothy O’Donnell, Diego Chowell, Ruben Fernandez-Rodriguez, Mihaela Skobe, Nicole Taylor, Seunghee Kim-Schulze, Robert P. Sebra, Doug Palmer, Eleanor Clancy-Thompson, Scott Hammond, Alice O. Kamphorst, Karl-Johan Malmberg, Emanuela Marcenaro, Pedro Romero, Rachel Brody, Mathias Viard, Yuko Yuki, Maureen Martin, Mary Carrington, Reza Mehrazin, Peter Wiklund, Ira Mellman, Sanjeev Mariathasan, Jun Zhu, Matthew D. Galsky, Nina Bhardwaj, Amir Horowitz
SummaryPD-1/PD-L1-blockade immunotherapies have limited efficacy in the treatment of muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma. Here, we show thatKLRC1(NKG2A) expression associates with improved survival and responsive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1254fb4f5982038f1a365d0992c3c6a3
https://doi.org/10.1101/2022.03.04.482960
https://doi.org/10.1101/2022.03.04.482960
Autor:
Haocheng Yu, John P. Sfakianos, Li Wang, Yang Hu, Jorge Daza, Matthew D. Galsky, Harkirat S. Sandhu, Olivier Elemento, Bishoy M. Faltas, Adam M. Farkas, Nina Bhardwaj, Jun Zhu, David J. Mulholland
Publikováno v:
Mol Cancer Ther
Most bladder cancers are poorly responsive to immune checkpoint blockade (ICB). With the need to define mechanisms of de novo resistance, including contributions from the tumor microenvironment (TME), we used single-cell transcriptional profiling to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5af900973f7c91d34067505a19a3be
https://pubmed.ncbi.nlm.nih.gov/36129800
https://pubmed.ncbi.nlm.nih.gov/36129800
Autor:
Bérengère Salomé, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber, Andrew Charap, Christian Hammer, Romain Banchereau, Adam M. Farkas, Dan Fu Ruan, Sudeh Izadmehr, Daniel Geanon, Geoffrey Kelly, Ronaldo M. de Real, Brian Lee, Kristin G. Beaumont, Sanjana Shroff, Yuanshuo A. Wang, Ying-chih Wang, Tin Htwe Thin, Monica Garcia-Barros, Everardo Hegewisch-Solloa, Emily M. Mace, Li Wang, Timothy O’Donnell, Diego Chowell, Ruben Fernandez-Rodriguez, Mihaela Skobe, Nicole Taylor, Seunghee Kim-Schulze, Robert P. Sebra, Doug Palmer, Eleanor Clancy-Thompson, Scott Hammond, Alice O. Kamphorst, Karl-Johan Malmberg, Emanuela Marcenaro, Pedro Romero, Rachel Brody, Mathias Viard, Yuko Yuki, Maureen Martin, Mary Carrington, Reza Mehrazin, Peter Wiklund, Ira Mellman, Sanjeev Mariathasan, Jun Zhu, Matthew D. Galsky, Nina Bhardwaj, Amir Horowitz
Publikováno v:
Cancer cell. 40(9)
Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1)-blockade immunotherapies have limited efficacy in the treatment of bladder cancer. Here, we show that NKG2A associates with improved survival and responsiveness to PD-L1 blockad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a471149980f9642d40f7eced3a3d285
https://pubmed.ncbi.nlm.nih.gov/36099881
https://pubmed.ncbi.nlm.nih.gov/36099881