Zobrazeno 1 - 10
of 538
pro vyhledávání: '"Adam M. Brickman"'
Autor:
Patrick Lao, Natalie Edwards, Lisi Flores-Aguilar, Mohamad Alshikho, Batool Rizvi, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Bradley T. Christian, Mark Mapstone, Benjamin Handen, Molly E. Zimmerman, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Adults with Down syndrome have a genetic form of Alzheimer’s disease (AD) and evidence of cerebrovascular disease across the AD continuum, despite few systemic vascular risk factors. The onset and progression of AD in Down syndrome is high
Externí odkaz:
https://doaj.org/article/4a432bd6f9aa4c0fbc74fe1536e6faa9
Autor:
Clarissa D. Morales, Dejania Cotton-Samuel, Patrick J. Lao, Julia F. Chang, Jeffrey D. Pyne, Mohamad J. Alshikho, Rafael V. Lippert, Kelsang Bista, Christiane Hale, Natalie C. Edwards, Kay C. Igwe, Kacie Deters, Molly E. Zimmerman, Adam M. Brickman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Secondary prevention clinical trials for Alzheimer’s disease (AD) target amyloid accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent other pathophysiological processes, such as small vess
Externí odkaz:
https://doaj.org/article/3981319700254ad994e2d7bb7c378a22
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Autor:
Natalie DiProspero, Mithra Sathishkumar, John Janecek, Anna Smith, Liv McMillan, Melissa Petersen, Nicholas Tustison, David B. Keator, Eric Doran, Christy L. Hom, Dana Nguyen, Howard Andrews, Sharon Krinsky‐McHale, Adam M. Brickman, H. Diana Rosas, Florence Lai, Elizabeth Head, Mark Mapstone, Wayne Silverman, Ira T. Lott, Sid O'Bryant, Michael A. Yassa
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Virtually all people with Down syndrome (DS) develop neuropathology associated with Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well as elevated plasma concentrations of neurofilament ligh
Externí odkaz:
https://doaj.org/article/7422d877af6a4072bb0972d4b84616f7
Autor:
Randolph S. Marshall, David S. Liebeskind, John Huston III, Lloyd J. Edwards, George Howard, James F. Meschia, Thomas G. Brott, Brajesh K. Lal, Donald Heck, Giuseppe Lanzino, Navdeep Sangha, Vikram S. Kashyap, Clarissa D. Morales, Dejania Cotton-Samuel, Andres M. Rivera, Adam M. Brickman, Ronald M. Lazar
Publikováno v:
Journal of Stroke, Vol 25, Iss 1, Pp 92-100 (2023)
Background and Purpose High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma,
Externí odkaz:
https://doaj.org/article/b33a939386444fd8b5d75d9ccd336f18
Autor:
Dorothee Schoemaker, Maria Clara Zanon Zotin, Kewei Chen, Kay C. Igwe, Clara Vila-Castelar, Jairo Martinez, Ana Baena, Joshua T. Fox-Fuller, Francisco Lopera, Eric M. Reiman, Adam M. Brickman, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract Background To promote the development of effective therapies, there is an important need to characterize the full spectrum of neuropathological changes associated with Alzheimer’s disease. In line with this need, this study examined white
Externí odkaz:
https://doaj.org/article/6cea0b3f9fa745c08f5508f5f4e4a33b
Autor:
Adam M. Brickman, Jennifer J. Manly, Lawrence S. Honig, Danurys Sanchez, Dolly Reyes‐Dumeyer, Rafael A. Lantigua, Jean Paul Vonsattel, Andrew F. Teich, Min Suk Kang, Jeffrey L. Dage, Richard Mayeux
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 5, Pp 756-761 (2022)
Abstract Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau
Externí odkaz:
https://doaj.org/article/8351af1ece434fbaa5a178f235ff75b8
Autor:
Darina T. Bassil, Meagan T. Farrell, Albert Weerman, Muqi Guo, Ryan G. Wagner, Adam M. Brickman, M. Maria Glymour, Kenneth M. Langa, Jennifer J. Manly, Brent Tipping, India Butler, Stephen Tollman, Lisa F. Berkman
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract INTRODUCTION We describe the development and feasibility of using an online consensus approach for diagnosing cognitive impairment and dementia in rural South Africa. METHODS Cognitive assessments, clinical evaluations, and informant intervi
Externí odkaz:
https://doaj.org/article/06056fd1d12a461193eaee814f77eb65
Autor:
Joanna L. Shuping, Dawn C. Matthews, Katarzyna Adamczuk, David Scott, Christopher C. Rowe, William C. Kreisl, Sterling C. Johnson, Ana S. Lukic, Keith A. Johnson, Pedro Rosa‐Neto, Randolph D. Andrews, Koen Van Laere, Lindsay Cordes, Larry Ward, Claire L. Wilde, Jerome Barakos, Derk D. Purcell, Davangere P. Devanand, Yaakov Stern, Jose A. Luchsinger, Cyrille Sur, Julie C. Price, Adam M. Brickman, William E. Klunk, Adam L. Boxer, Sulantha S. Mathotaarachchi, Patrick J. Lao, Jeffrey L. Evelhoch
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 1, Pp n/a-n/a (2023)
Abstract Background The positron emission tomography (PET) radiotracer [18F]MK‐6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, a
Externí odkaz:
https://doaj.org/article/d292970eb93a4e9c97bfc3b0e3aca902
Autor:
Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Márquez, Steven J. Granger, Myra S. Larson, Blake A. Miranda, Martina K. Hollearn, Liv McMillan, Bin Nan, Nicholas J. Tustison, Patrick J. Lao, Adam M. Brickman, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Publikováno v:
NeuroImage: Clinical, Vol 37, Iss , Pp 103308- (2023)
White matter hyperintensities are a marker of small vessel cerebrovascular disease that are strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well-documented in aging and Alzheimer’s disease and is associated
Externí odkaz:
https://doaj.org/article/0f2090c3b3dd42b494583db425fa0478