Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adam M Thorne"'
Autor:
Aad P van den Berg, Hans Blokzijl, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Ton Lisman, Vincent E de Meijer, Anne Loes Van den Boom, Joost M Klaase, Peter Meyer, Robert J Porte, Frederike G I van Vilsteren, Frans J C Cuperus, Martijn P D Haring, Isabel M A Brüggenwirth, Veerle A Lantinga, Michel Rayar, Koen M E M Reyntjens, Carlijn I Buis, Suomi MG Fouraschen, Frederik JH Hoogwater, Mark Meerdink, Maarten W Nijkamp, A Michel Rayar, Ilhama F Abbasova, Meine H Fernhout, Ernesto R R Muskiet, Jaap J Vos, Miriam Zeillemaker, Bianca Lascaris, Carol C Pamplona, Adam M Thorne, Silke B Bodewes
Publikováno v:
BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/3f50cfea28074549bfe7bb861754b74b
Autor:
Adam M. Thorne, Justina C. Wolters, Bianca Lascaris, Silke B. Bodewes, Veerle A. Lantinga, Otto B. van Leeuwen, Iris E. M. de Jong, Kirill Ustyantsev, Eugene Berezikov, Ton Lisman, Folkert Kuipers, Robert J. Porte, Vincent E. de Meijer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Normothermic machine perfusion (NMP) after static cold storage is increasingly used for preservation and assessment of human donor livers prior to transplantation. Biliary viability assessment during NMP reduces the risk of post-transplant b
Externí odkaz:
https://doaj.org/article/4196b91cef814f6483a06b7a72696332
Autor:
Isabel M.A. Brüggenwirth, Veerle A. Lantinga, Bianca Lascaris, Adam M. Thorne, Mark Meerdink, Ruben H. de Kleine, Hans Blokzijl, Aad P. van den Berg, Koen M.E.M. Reyntjens, Ton Lisman, Robert J. Porte, Vincent E. de Meijer, Cyril Moers, Diethard Monbaliu, Sijbrand H. Hofker, Jan Bottema, Hildegaard S. Franke, Marieke T. de Boer, Anne Loes van den Boom, Carlijn I. Buis, Suomi M.G. Fouraschen, Frederik J.H. Hoogwater, Joost M. Klaase, Ruben H.J. de Kleine, Maarten W. Nijkamp, A. Michel Rayar, Frans J.C. Cuperus, Frans van der Heide, Frederike G.I. van Vilsteren, Ilhama F. Abbasova, Meine H. Fernhout, Peter Meyer, Ernesto R.R. Muskiet, Jaap J. Vos, Miriam Zeillemaker, Martijn P.D. Haring, Carol C. Pamplona, Vivianne Veenma, Otto B. van Leeuwen, Silke B. Bodewes, Jelle Adelmeijer, Janneke Wiersema-Buist, Marius van den Heuvel
Publikováno v:
EClinicalMedicine, Vol 68, Iss , Pp 102411- (2024)
Summary: Background: Liver transplantation is traditionally performed around the clock to minimize organ ischemic time. However, the prospect of prolonging preservation times holds the potential to streamline logistics and transform liver transplanta
Externí odkaz:
https://doaj.org/article/29158e4bdd724fc08b40eb8e81f7654a
Autor:
Otto B. van Leeuwen, Silke B. Bodewes, Veerle A. Lantinga, Martijn P.D. Haring, Adam M. Thorne, Isabel M.A. Brüggenwirth, Aad P. van den Berg, Marieke T. de Boer, Iris E.M. de Jong, Ruben H.J. de Kleine, Bianca Lascaris, Maarten W.N. Nijsten, Koen M.E.M. Reyntjens, Vincent E. de Meijer, Robert J. Porte
Publikováno v:
American Journal of Transplantation, 22(6), 1658-1670. Wiley
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment of high-risk donor livers, whereas dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia-reperfusion injury. We aimed to resuscitate and test
Autor:
Vincent E de Meijer, Robert J. Porte, Bianca Lascaris, Adam M Thorne, Maarten W. N. Nijsten, Ton Lisman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G183-G200
Although short‐term machine perfusion (≤24 h) allows for resuscitation and viability assessment of high‐risk donor livers, the donor organ shortage might be further remedied by long‐term perfusion machines. Extended preservation of injured do
Autor:
Isabel M. A. Brüggenwirth, Willemijn S. Plas, Otto B. Leeuwen, Adam M. Thorne, Michel Rayar, Vincent E. Meijer, Robert J. Porte
Publikováno v:
ARTIFICIAL ORGANS, 46(2):14135, 201-209. Wiley
Background: During donor organ procurement and subsequent static cold storage (SCS), hepatic adenosine triphosphate (ATP) levels are progressively depleted, which contributes to ischemia-reperfusion injury (IRI). We sought to investigate a simple app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1386a153334509f63ca1ecf77d6b6ebc
https://research.rug.nl/en/publications/eb28314b-6e6b-4790-96eb-b23fd35a4c59
https://research.rug.nl/en/publications/eb28314b-6e6b-4790-96eb-b23fd35a4c59
Autor:
Otto B. van Leeuwen, Ton Lisman, Robert J. Porte, Bianca Lascaris, Silke B Bodewes, Rinse Ubbink, Maarten W. N. Nijsten, Vincent E de Meijer, Diethard Monbaliu, Adam M Thorne
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 235, p 235 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Oxygenated ex situ machine perfusion of donor livers is an alternative for static cold preservation that can be performed at temperatures from 0 °C to 37 °C. Organ metabolism depends on oxygen to produce adenosine triphosphate and temperatures belo
Autor:
Maarten W. N. Nijsten, Adam M Thorne, Isabel M A Brüggenwirth, Vincent E de Meijer, Rinse Ubbink, Robert J. Porte
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 319(1):G43-G50
Hyperthermia-induced changes in liver physiology and metabolism: A rationale for hyperthermic machine perfusion. Am J Physiol Gastrointest Liver Physiol 319: G43-G50, 2020. First published June 8, 2020; doi:10.1152/ajpgi.00101.2020.-Liver transplanta
Autor:
Darragh P. O’Brien, Adam M. Thorne, Honglei Huang, Elisa Pappalardo, Xuan Yao, Peter Søndergaard Thyrrestrup, Kristian Ravlo, Niels Secher, Rikke Norregaard, Rutger J. Ploeg, Bente Jespersen, Benedikt M. Kessler
Publikováno v:
O'Brien, D P, Thorne, A M, Huang, H, Pappalardo, E, Yao, X, Thyrrestrup, P S, Ravlo, K, Secher, N, Norregaard, R, Ploeg, R J, Jespersen, B & Kessler, B M 2022, ' Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model ', Clinical proteomics, vol. 19, no. 1, 6 . https://doi.org/10.1186/s12014-022-09343-3
O’Brien, D P, Thorne, A M, Huang, H, Pappalardo, E, Yao, X, Thyrrestrup, P S, Ravlo, K, Secher, N, Norregaard, R, Ploeg, R J, Jespersen, B & Kessler, B M 2022, ' Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model ', Clinical Proteomics, vol. 19, 6 . https://doi.org/10.1186/s12014-022-09343-3
O’Brien, D P, Thorne, A M, Huang, H, Pappalardo, E, Yao, X, Thyrrestrup, P S, Ravlo, K, Secher, N, Norregaard, R, Ploeg, R J, Jespersen, B & Kessler, B M 2022, ' Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model ', Clinical Proteomics, vol. 19, 6 . https://doi.org/10.1186/s12014-022-09343-3
Background Remote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that is inherent to organ transplantation. Using a porcine kidney transplant model, we aimed to decipher
Autor:
Honglei Huang, Bas W M van Balkom, Adam M. Thorne, Rutger J. Ploeg, Sarah Bonham, Henri G. D. Leuvenink, L Leonie van Leeuwen, Nora A Spraakman, Aukje Brat, Benedikt M. Kessler
Publikováno v:
Transplant International, 34(9), 1618-1629. Wiley
Assessment of donor kidney quality is based on clinical scores or requires biopsies for histological assessment. Noninvasive strategies to identify and predict graft outcome at an early stage are, therefore, needed. We evaluated the perfusate of dona