Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Adam M Szlachetka"'
Autor:
Yazen Alnouti, Howard S. Fox, Nagsen Gautam, Adam M. Szlachetka, Shannon Callen, Benson J Edagwa, Howard E. Gendelman, Brenda Morsey, Tian Zhou, Benjamin G. Lamberty, JoEllyn M McMillan
Publikováno v:
AIDS. 33:585-588
Long-acting antiretrovirals can improve therapy and prevention for HIV-1 infection. Current long-acting cabotegravir (CAB LAP) can be administered every other month. Previously, we demonstrated that a myristoylated CAB prodrug encased in poloxamer 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeeca7c7974dce4c33af773850aced6
https://doi.org/10.1097/qad.0000000000002032
https://doi.org/10.1097/qad.0000000000002032
Autor:
Wenkuan Li, Yazen Alnouti, Devendra Kumar, Adam M. Szlachetka, Nagsen Gautam, Qiaoyu Pan, Nathan Smith, Tanmay A. Kulkarni, Brady Sillman, JoEllyn M McMillan, Benson J Edagwa, Howard E. Gendelman, Bhagya Laxmi Dyavar Shetty, Aditya N. Bade
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
A once every eight-week cabotegravir (CAB) long-acting parenteral is more effective than daily oral emtricitabine and tenofovir disoproxil fumarate in preventing human immunodeficiency virus type one (HIV-1) transmission. Extending CAB dosing to a ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d08dcd211b4f2afe0532ce212f79ab
https://doi.org/10.1038/s41467-021-23668-x
https://doi.org/10.1038/s41467-021-23668-x
Autor:
Howard E. Gendelman, JoEllyn M McMillan, Yazen Alnouti, Nagsen Gautam, Prasanta K. Dash, Santhi Gorantla, R. Lee Mosley, Tian Zhou, Ted Kocher, Hang Su, Bhagya Laxmi Dyavar Shetty, Larisa Y. Poluektova, Adam M. Szlachetka, Benjamin G. Lamberty, Zhiyi Lin, Benson J Edagwa, Howard S. Fox
Publikováno v:
Biomaterials
Long-acting parenteral (LAP) antiretroviral drugs have generated considerable interest for treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly potent integrase inhibitor, with a half-life of up to 54 days, allowin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfe87189d3a7a9b134824007fdfea41
https://doi.org/10.1016/j.biomaterials.2017.10.023
https://doi.org/10.1016/j.biomaterials.2017.10.023
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19258 (2011)
Methamphetamine (METH), an addictive psycho-stimulant drug exerts euphoric effects on users and abusers. It is also known to cause cognitive impairment and neurotoxicity. Here, we hypothesized that METH exposure impairs the glucose uptake and metabol
Externí odkaz:
https://doaj.org/article/bc3ae6f402f84d7f83f460f3f694bfa7
Autor:
Brady Sillman, Tai-Yuen Yue, Howard E. Gendelman, Nagsen Gautam, Melinda Wojtkiewicz, R. Lee Mosley, Adam M. Szlachetka, Bhagya Laxmi Dyavar Shetty, Sruthi Sravanam, Howard S. Fox, Jane L. Meza, Yazen Alnouti, James R. Hilaire, Aditya N. Bade, Tanmay A. Kulkarni, Paul L. Domanico, Benson J Edagwa, Brenda Morsey, Benjamin G. Lamberty, Gary Moore, JoEllyn M McMillan
Publikováno v:
Nature materials. 19(8)
Long-acting cabotegravir (CAB) extends antiretroviral drug administration from daily to monthly. However, dosing volumes, injection site reactions and health-care oversight are obstacles towards a broad usage. The creation of poloxamer-coated hydroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edce3d8d71ee6472b6755874ca83dc4b
https://pubmed.ncbi.nlm.nih.gov/32704135
https://pubmed.ncbi.nlm.nih.gov/32704135
Autor:
Melinda Wojtkiewicz, Nagsen Gautam, Brady Sillman, Jonathan Herskovitz, Benson J Edagwa, James R. Hilaire, Howard S. Fox, Sruthi Sravanam, Yazen Alnouti, Adam M. Szlachetka, Benjamin G. Lamberty, Howard E. Gendelman, JoEllyn M McMillan, Aditya N. Bade, Bhagya Laxmi Dyavar Shetty, Prasanta K. Dash
Publikováno v:
J Control Release
Antiretroviral therapy requires lifelong daily dosing to attain viral suppression, restore immune function, and improve quality of life. As a treatment alternative, long-acting (LA) antiretrovirals can sustain therapeutic drug concentrations in blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fec3ae992efa3b210529137caa07982
https://europepmc.org/articles/PMC6875695/
https://europepmc.org/articles/PMC6875695/
Publikováno v:
International journal of physiology, pathophysiology and pharmacology. 11(4)
Although the combination of highly active antiretroviral therapy (cART) can remarkably control human immunodeficiency virus type-1 (HIV-1) replication, it fails to cure HIV/AIDS disease. It is attributed to the incapability of cART to eliminate persi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb881f2ac509f54892a3b9ff878e5fe7
https://pubmed.ncbi.nlm.nih.gov/31523362
https://pubmed.ncbi.nlm.nih.gov/31523362
Autor:
P. M. Abdul-Muneer, Xiaotang Ma, James Haorah, Adam M. Szlachetka, Saleena Alikunju, Heather Schuetz
Publikováno v:
Mol Neurobiol
Wernicke's encephalopathy, a common neurological disease, is caused by thiamine (vitamin B1) deficiency. Neuropathy resulting from thiamine deficiency is a hallmark of Wernicke-Korsakoff syndrome in chronic alcohol users. The underlying mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423cb436a0667725c60b0543c821f88f
https://pubmed.ncbi.nlm.nih.gov/29128903
https://pubmed.ncbi.nlm.nih.gov/29128903
Publikováno v:
Psychopharmacology. 214:707-718
Evidence shows that alcohol intake causes oxidative neuronal injury and neurocognitive deficits that are distinct from the classical Wernicke-Korsakoff neuropathy. Our previous findings indicated that alcohol-elicited blood-brain barrier (BBB) damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1009b2723896a4e1e9a3aff3003932ae
https://doi.org/10.1007/s00213-010-2076-4
https://doi.org/10.1007/s00213-010-2076-4
Autor:
Jocelyn Jones, Yuri Persidsky, Jianuo Liu, James Haorah, James Keblesh, Allyson Lamb, Adam M. Szlachetka, Saleena Alikunju, Terrence M. Donohue, Catherine Haorei, Travis J. Rump, Huangui Xiong, Matthew C. Zimmerman, P. M. Abdul Muneer
Publikováno v:
Free Radical Biology and Medicine. 49:1494-1504
The studies presented here demonstrate the protective effect of acetyl-L-carnitine (ALC) against alcohol-induced oxidative neuroinflammation, neuronal degeneration, and impaired neurotransmission. Our findings reveal the cellular and biochemical mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35423d579773d1b8a3d9031e7084f78a
https://doi.org/10.1016/j.freeradbiomed.2010.08.011
https://doi.org/10.1016/j.freeradbiomed.2010.08.011