Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Adam M Fontebasso"'
Autor:
Kednapa Thavorn, Peter Glen, Adam M Fontebasso, Sonshire Figueira, Jacinthe Lampron, Maher Matar
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 5, Iss 1 (2020)
Background Trauma is a cause of significant morbidity and mortality globally, and patients with major trauma require specialized settings for multidisciplinary care. We sought to enumerate the variability of costs of caring for patients at a Canadian
Externí odkaz:
https://doaj.org/article/7ed2de25b7d14c6b82feb07bffb04ef3
Publikováno v:
Journal of Trauma and Acute Care Surgery. 89:1225-1232
BACKGROUND Hemothorax is a common sequelae following thoracic trauma and is associated with significant morbidity and mortality. Current guidelines recommend all traumatic hemothoraces be considered for drainage with tube thoracostomy (TT), regardles
Autor:
David T.W. Jones, Yusanne Ma, Xin Wang, Betty Luu, Cynthia Hawkins, Adrian Ally, Marc Remke, John S. Myseros, Nada Jabado, Adam M. Fontebasso, Volker Hovestadt, Michael D. Taylor, Craig Daniels, Borja L. Holgado, Steffen Albrecht, Uri Tabori, David Malkin, Andrey Korshunov, Diana M. Merino, Stuart Horswell, Rebecca Carlsen, James T. Rutka, Daniel Picard, Marco A. Marra, David Shih, Angela Tam, Patrick Plettner, Roger J. Packer, Gary D. Bader, Erin N. Kiehna, Hamza Farooq, Eloi Mercier, John Peacock, Stephen C. Mack, A. Sorana Morrissy, Sameer Agnihotri, Jonathon Torchia, Vijay Ramaswamy, Young Cheng, Kane Tse, Steven J.M. Jones, Laura K. Donovan, Richard A. Moore, Sunit Das, Annie Huang, Nina Thiessen, James Loukides, Darlene Lee, Yisu Li, Marcel Kool, Charles Swanton, Eric Chuah, Tenzin Gayden, Xiaochong Wu, Michael Mayo, Eric Bouffet, Chelsea Mayoh, Peter Lichter, Noreen Dhalla, Brian R. Rood, Jacek Majewski, Ulrich Schüller, Haiyan I. Li, Richard Corbett, Tina Wong, Paul A. Northcott, Pawel Buczkowicz, Florence M.G. Cavalli, Yuan Yao Thompson, William Long, Maria C. Vladoiu, Peter B. Dirks, Hamid Nikbakht, Livia Garzia, Stefan M. Pfister, Jacqueline E. Schein, Simon Papillon-Cavanagh, Andrew J. Mungall, Jüri Reimand
Publikováno v:
Nature genetics
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification of biomarkers and the development of targeted therapies that will be effective against the
Autor:
Pierre Fiset, Adam M. Fontebasso, Jacek Majewski, Tenzin Gayden, Nicolas De Jay, Hamid Nikbakht, Nada Jabado, Steffen Albrecht
Publikováno v:
Pediatric Blood & Cancer. 64:275-278
A cerebellar pilocytic astrocytoma (PA) in a child recurred first with a PA histology and then with features of a ganglioglioma (GG). Molecular genetic analyses of the tumors confirmed a BRAF V600E mutation in all. They also all harbored a T202M muta
Autor:
László Bognár, Sébastien Brunet, David T.W. Jones, Andrey Korshunov, Geneviève Bourret, Denise Bechet, Dong-Anh Khuong-Quang, Jose-Luis Montes, Nicolas De Jay, Noha Gerges, Pierre Lepage, Huriye Seker-Cin, Tenzin Gayden, Tony Kwan, V. Peter Collins, Uri Tabori, Margret Shirinian, Werner Paulus, M Kool, Stefan M. Pfister, Adam M. Fontebasso, Hendrik Witt, Karine Jacob, Barbara Hutter, Jean-Pierre Farmer, Peter Hauser, Almos Klekner, Damien Faury, Jeffrey Atkinson, Nada Jabado, Steffen Albrecht, Alexandre Montpetit, Sally R. Lambert, Miklós Garami, Martin Hasselblatt
Publikováno v:
Oncotarget
Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid genomes were identified in 45
Autor:
Nada Jabado, Adam M. Fontebasso
Publikováno v:
Critical Reviews in Oncogenesis. 20:271-299
Primary malignant brain tumors remain a disproportionate cause of morbidity and mortality in humans. A number of studies exploring the cancer genome of brain tumors across ages using integrated genetics and epigenetics and next-generation sequencing
Publikováno v:
Brain Pathology. 23:210-216
Primary brain tumors occur in 8 out of 100 000 people and are the leading cause of cancer-related death in children. Among brain tumors, high-grade astrocytomas (HGAs) including glioblastoma multiforme (GBM) are aggressive and are lethal human cancer
Autor:
Peter Hauser, László Bognár, Alfredo Staffa, Almos Klekner, Xiaoyang Liu, Djihad Hadjadj, Stephan Busche, Miklós Garami, Adam Fleming, Adam M. Fontebasso, Marcel Kool, David T.W. Jones, Jeremy Schwartzentruber, Jacek Majewski, Stefan M. Pfister, Krzystof Zakrzewski, Nada Jabado, Noha Gerges, Dominik Sturm, Hendrik Witt, Steffen Albrecht, Dong Anh Khuong-Quang, Pierre Lepage, Pawel P. Liberski, Alexandre Montpetit, Damien Faury, Gelareh Zadeh, Andrey Korshunov, Magdalena Zakrzewska
Publikováno v:
Acta Neuropathologica
Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To identify additional driver mutations in HGGs, we investigated a cohort of 60 pediatric HGGs
Autor:
Nada Jabado, Djihad Hadjadj, Nesrin Sabha, Marcel Kool, Andrey Korshunov, Adam M. Fontebasso, Jeremy Schwartzentruber, Damien Faury, Gelareh Zadeh, Sidney Croul, Guido Reifenberger, Jacek Majewski, Steffen Albrecht, Peter M. Siegel, Noha Gerges, Xiaoyang Liu, Adam Fleming, Zhifeng Dong, David T.W. Jones, Martje Tönjes, Dong-Anh Khuong-Quang, Stefan M. Pfister
Publikováno v:
Acta Neuropathologica. 124:615-625
Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways including recurrent mutations in H3F3A and mutations in ATRX (α-thalassemia/mental-retardation-syn
Autor:
Nada Jabado, Eric Bouffet, Andrey Korshunov, Jacek Majewski, David T.W. Jones, Alexandre Montpetit, Marcel Kool, Patricia Rakopoulos, Andreas von Deimling, Jeremy Schwartzentruber, Peter Lichter, Geneviève Bourret, Dong Anh Khuong-Quang, Steffen Albrecht, Guillaume Bourque, Damien Faury, Ute Bartels, Adam Fleming, Pierre Lepage, Louis Letourneau, Mathieu Bourgey, Cynthia Hawkins, Adam M. Fontebasso, Dominik Sturm, Stefan M. Pfister, Xiaoyang Liu, Pawel Buczkowicz
Publikováno v:
Acta Neuropathologica
Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for