Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam M Crowe"'
Autor:
Brian C VanderVen, Ruth J Fahey, Wonsik Lee, Yancheng Liu, Robert B Abramovitch, Christine Memmott, Adam M Crowe, Lindsay D Eltis, Emanuele Perola, David D Deininger, Tiansheng Wang, Christopher P Locher, David G Russell
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)
Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we i
Externí odkaz:
https://doaj.org/article/6109150c12bc4f40969bd55a5cb7ecca
Autor:
Adam M, Crowe, Jessica M C, Krekhno, Kirstin L, Brown, Jayesh A, Kulkarni, Katherine C, Yam, Lindsay D, Eltis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8eede16748086e121f069379ec4b4bb4
https://pubmed.ncbi.nlm.nih.gov/36161908
https://pubmed.ncbi.nlm.nih.gov/36161908
Autor:
Adam M. Crowe, Jessica M. C. Krekhno, Kirstin L. Brown, Jayesh A. Kulkarni, Katherine C. Yam, Lindsay D. Eltis
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mycobacterium abscessus , an opportunistic pathogen responsible for pulmonary infections, contains genes predicted to encode two steroid catabolic pathways: a cholesterol catabolic pathway similar to that of Mycobacterium tuberculosis and a 4-androst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cee27297b230658384ca5e3afae7f2d1
https://doi.org/10.1073/pnas.2207505119
https://doi.org/10.1073/pnas.2207505119
Autor:
Adam M. Crowe, Israël Casabon, Kirstin L. Brown, Jie Liu, Jennifer Lian, Jason C. Rogalski, Timothy E. Hurst, Victor Snieckus, Leonard J. Foster, Lindsay D. Eltis
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Most mycolic acid-containing actinobacteria and some proteobacteria use steroids as growth substrates, but the catabolism of the last two steroid rings has yet to be elucidated. In Mycobacterium tuberculosis, this pathway includes virulence
Externí odkaz:
https://doaj.org/article/8a695f8dfbf74f748bcfad84bcde434f
Autor:
John E. Gadbery, Jie Liu, Israël Casabon, Nicole S. Sampson, Xinxin Yang, Lindsay D. Eltis, Tianao Yuan, James W. Round, Keith T Story, Matthew F. Wipperman, Adam M. Crowe
Publikováno v:
Biochemistry
Steroid-degrading bacteria, including Mycobacterium tuberculosis (Mtb), utilize an architecturally distinct subfamily of acyl coenzyme A dehydrogenases (ACADs) for steroid catabolism. These ACADs are α2β2 heterotetramers that are usually encoded by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c46afd01103899593f37a9c24fb299
https://doi.org/10.1021/acs.biochem.0c00005
https://doi.org/10.1021/acs.biochem.0c00005
Autor:
Ngoc Anh Thu Ho, Stephanie S. Dawes, Lindsay D. Eltis, J. Shaun Lott, Chen Gao, Edward N. Baker, Sharon L. Kendall, Adam M. Crowe, Isra eumll Casabon
Publikováno v:
Journal of Biological Chemistry. 291:7256-7266
Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100c8f2789390db0de6cd8a577a04732
https://doi.org/10.1074/jbc.m115.707760
https://doi.org/10.1074/jbc.m115.707760
Autor:
Adam M, Crowe, Sean D, Workman, Nobuhiko, Watanabe, Liam J, Worrall, Natalie C J, Strynadka, Lindsay D, Eltis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(15)
All steroid-degrading bacteria utilize IpdAB, a predicted CoA transferase (CoT) that has been implicated in the hydrolysis of a carbon–carbon bond, an unprecedented reaction in CoTs. In Mycobacterium tuberculosis, IpdAB is required for degrading ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2305abf1be543b0411b030024b390d82
https://pubmed.ncbi.nlm.nih.gov/29581275
https://pubmed.ncbi.nlm.nih.gov/29581275
Autor:
Sean D. Workman, Natalie C. J. Strynadka, Nobuhiko Watanabe, Lindsay D. Eltis, Adam M. Crowe, Liam J. Worrall
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Mycobacterium tuberculosis (Mtb) grows on host-derived cholesterol during infection. IpdAB, found in all steroid-degrading bacteria and a determinant of pathogenicity, has been implicated in the hydrolysis of the last steroid ring. Phylogenetic analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ae4f03ec88d716159d83b54664fc75
https://doi.org/10.1073/pnas.1717015115
https://doi.org/10.1073/pnas.1717015115
Autor:
Lindsay D. Eltis, Estefanía Merino, Álvaro Barrientos, José M. Luengo, Joaquín Rodríguez, Bodo Philipp, Adam M. Crowe, Johannes Holert, Elías R. Olivera, Israël Casabon
Publikováno v:
Environmental Microbiology. 17:47-63
Summary Pseudomonas putida DOC21, a soil-dwelling proteobacterium, catabolizes a variety of steroids and bile acids. Transposon mutagenesis and bioinformatics analyses identified four clusters of steroid degradation (std) genes encoding a single cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce743c8b558c31490a7b93647995897
https://doi.org/10.1111/1462-2920.12395
https://doi.org/10.1111/1462-2920.12395
Autor:
Hans Adomat, Manoj Monga, Ricardo Miyaoka, Olga Arsovska, Joey Lo, Chelsea Elwood, Emily C. Chou, Ben H. Chew, Adam M. Crowe, Dirk Lange, Emma Tomlinson-Guns
Publikováno v:
Biofouling. 29:1115-1122
Ureteral stents are fraught with problems. A conditioning film attaches to the stent surface within hours of implantation; however, differences between stent types and their role in promoting encrustation and bacterial adhesion and colonization remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25b385b83bfbfa87163c9855bf9439f
https://doi.org/10.1080/08927014.2013.829049
https://doi.org/10.1080/08927014.2013.829049