Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).

Autor: Sudha K Iyengar, John R Sedor, Barry I Freedman, W H Linda Kao, Matthias Kretzler, Benjamin J Keller, Hanna E Abboud, Sharon G Adler, Lyle G Best, Donald W Bowden, Allison Burlock, Yii-Der Ida Chen, Shelley A Cole, Mary E Comeau, Jeffrey M Curtis, Jasmin Divers, Christiane Drechsler, Ravi Duggirala, Robert C Elston, Xiuqing Guo, Huateng Huang, Michael Marcus Hoffmann, Barbara V Howard, Eli Ipp, Paul L Kimmel, Michael J Klag, William C Knowler, Orly F Kohn, Tennille S Leak, David J Leehey, Man Li, Alka Malhotra, Winfried März, Viji Nair, Robert G Nelson, Susanne B Nicholas, Stephen J O'Brien, Madeleine V Pahl, Rulan S Parekh, Marcus G Pezzolesi, Rebekah S Rasooly, Charles N Rotimi, Jerome I Rotter, Jeffrey R Schelling, Michael F Seldin, Vallabh O Shah, Adam M Smiles, Michael W Smith, Kent D Taylor, Farook Thameem, Denyse P Thornley-Brown, Barbara J Truitt, Christoph Wanner, E Jennifer Weil, Cheryl A Winkler, Philip G Zager, Robert P Igo, Robert L Hanson, Carl D Langefeld, Family Investigation of Nephropathy and Diabetes (FIND)

Publikováno v: PLoS Genetics, Vol 11, Iss 8, p e1005352 (2015)

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident e

Externí odkaz: https://doaj.org/article/60f7e3700dd5412789cd4b99b548f387

Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1.

Autor: Jung Eun Lee, Tomohito Gohda, William H Walker, Jan Skupien, Adam M Smiles, Rita R Holak, Jackson Jeong, Kevin P McDonnell, Andrzej S Krolewski, Monika A Niewczas

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58007 (2013)

Recent studies demonstrated that circulating fibroblast growth factor (FGF)-23 was associated with risk of end stage renal disease (ESRD) and mortality. This study aims to examine whether the predictive effect of FGF-23 is independent from circulatin

Externí odkaz: https://doaj.org/article/cbf015f726274b05b6580187b1680dca

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (

Autor: Josyf C, Mychaleckyj, Erkka, Valo, Takaharu, Ichimura, Tarunveer S, Ahluwalia, Christian, Dina, Rachel G, Miller, Ivan G, Shabalin, Beata, Gyorgy, JingJing, Cao, Suna, Onengut-Gumuscu, Eiichiro, Satake, Adam M, Smiles, Jani K, Haukka, David-Alexandre, Tregouet, Tina, Costacou, Kristina, O'Neil, Andrew D, Paterson, Carol, Forsblom, Hillary A, Keenan, Marcus G, Pezzolesi, Marlon, Pragnell, Andrzej, Galecki, Stephen S, Rich, Niina, Sandholm, Ronald, Klein, Barbara E, Klein, Katalin, Susztak, Trevor J, Orchard, Ron, Korstanje, George L, King, Samy, Hadjadj, Peter, Rossing, Joseph V, Bonventre, Per-Henrik, Groop, James H, Warram, Andrzej S, Krolewski

Publikováno v: J Am Soc Nephrol

Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common variants through disruption of their encoded protein. We searched for rare variants associated with onset of ESKD in individuals with type 1 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b686049d78408da97a1fe56f0b11722
https://pubmed.ncbi.nlm.nih.gov/34599034

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

Autor: Emma Ahlqvist, Catherine Godson, Darrell Andrews, Per-Henrik Groop, Raimund Weitgasser, Andrzej S. Krolewski, Kristine E. Lee, Lina Radzeviciene, Stuart J. McGurnaghan, Colin N. A. Palmer, Joanne B. Cole, Shelley B. Bull, Andrew P. Boright, Lars Stechemesser, Katalin Susztak, Barbara E.K. Klein, Wei-Min Chen, Kerstin Brismar, Carol Forsblom, Jani K. Haukka, Beata Gyorgy, Adam M. Smiles, Jose C. Florez, Harvest F. Gu, Niina Sandholm, Leif Groop, Gareth J. McKay, Maria Hughes, Mark I. McCarthy, Joel N. Hirschhorn, Athina Spiliopoulou, Michael Mauer, Samy Hadjadj, Nicolae Mircea Panduru, Helen M. Colhoun, Jingchuan Guo, Robert G. Nelson, Matthias Kretzler, Valdis Pīrāgs, Marcus G. Pezzolesi, Tarunveer S. Ahluwalia, Rasa Verkauskiene, Michel Marre, Linda T. Hiraki, Janet K. Snell-Bergeon, Bernhard Paulweber, Stephen S. Rich, Erkka Valo, Chen Di Liao, David M. Maahs, Vita Rovīte, Rachel G. Miller, Eoin P. Brennan, Peter Rossing, Natalie R. van Zuydam, Maria Luiza Caramori, Jan Skupien, Rany M. Salem, A. Peter Maxwell, Paul M. McKeigue, Maria Lajer, Gianpaolo Zerbini, Chengxiang Qiu, David-Alexandre Trégouët, Henrik Falhammar, Jennifer Todd, Rajasree Menon, Jelizaveta Sokolovska, Valma Harjutsalo, Anna Möllsten, Ronald Klein, Xiaoyu Gao, Viji Nair, Jihwan Park, Amy Jayne McKnight, Jing Jing Cao, Silvia Maestroni, Edita Prakapiene, Ian H. de Boer, Finian Martin, Andrew D. Paterson, Suna Onengut-Gumuscu, Ross Doyle, Hyun Min Kang, Angelo J. Canty, Andrew C. Liu, Tina Costacou, Carine M. Boustany-Kari

Publikováno v: Salem, R M, Todd, J N, Sandholm, N, Rossing, P, Rich, S S, Hirschhorn, J N, Florez, J C & SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium 2019, ' Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen ', Journal of the American Society of Nephrology, vol. 30, no. 10, pp. 2000-2016 . https://doi.org/10.1681/ASN.2019030218
2019, ' Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen ', Journal of the American Society of Nephrology . https://doi.org/10.1681/ASN.2019030218
SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium, Kretzler, M, Susztak, K, Colhoun, H M, Krolewski, A S, Paterson, A D, Groop, P-H, Rich, S S, Hirschhorn, J N & Florez, J C 2019, ' Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen ', Journal of the American Society of Nephrology, vol. 30, no. 10, pp. 2000-2016 . https://doi.org/10.1681/ASN.2019030218
J Am Soc Nephrol

BACKGROUND: Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown.METHODS: To identify genetic variants predisposin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c5428acfac62f36ff4056292157371
https://curis.ku.dk/portal/da/publications/genomewide-association-study-of-diabetic-kidney-disease-highlights-biology-involved-in-glomerular-basement-membrane-collagen(b30453e6-4f70-4b36-83fd-2afa1bcee756).html

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

Autor: Pierre-Jean Saulnier, Jihwan Park, Katalin Susztak, Zaipul I. Md Dom, Alessandro Doria, Monika A. Niewczas, Carl F. Ware, Kevin L. Duffin, Jonathan M. Wilson, Andrew Schlafly, Robert G. Nelson, Meda E. Pavkov, Jan Skupien, Paolo Fiorina, Hetal Shah, Adam M. Smiles, Jennifer K. Sun, Christopher A Simeone, Chengxiang Qiu, Helen C. Looker, Eiichiro Satake, Matthias Kretzler, Andrzej S. Krolewski, Viji Nair

Publikováno v: Nature medicine

Chronic inflammation is postulated to be involved in development of end stage renal disease (ESRD) in diabetes, but which specific circulating inflammatory proteins contribute to this risk remains unknown. To study this we examined 194 circulating in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1b0194a4d6443ea1040c851ce20974
https://ruj.uj.edu.pl/xmlui/handle/item/112643