Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Adam M, Fivush"'
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967
Autor:
Bruce A. Dressman, Veronique Dehlinger, Rosa Maria A. Simmons, Smriti Iyengar, Steven Marc Massey, John T. Catlow, David L. McKinzie, Langu Peng, Adam M. Fivush, Edda F. Roberts, Barry Peter Clark, Mallorie R. Bracey-Walker, James A. Monn, Junliang Hao, Steven C. Peters, Steven S. Henry, Beverly A. Heinz, Sean P. Hollinshead, Anita D. Tepool, Steven Swanson, Patrick L. Love, Thomas C. Britton, Helene Rudyk, Benjamin Paul Vokits
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1249-1252
A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold. One compound of this series, (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef86f59bea2ecb1e4670f9d5e462c59f
https://doi.org/10.1016/j.bmcl.2013.01.009
https://doi.org/10.1016/j.bmcl.2013.01.009
Autor:
Gary Gilmour, Dale M. Edgar, Francois Gastambide, Lorena Taboada, Beverly A. Heinz, Elaine Shanks, Brian G. Getman, Lourdes Prieto, Janice W. Smith, Lisa M. Broad, Thomas C. Britton, Keith A. Wafford, Adam M. Fivush, Mark D. Tricklebank, Andrew McCarthy, Ellen M. Colvin
Publikováno v:
Neuropharmacology. 64:224-239
The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::499e6fd6587a804b5c1c9dc77cbb6b56
https://doi.org/10.1016/j.neuropharm.2012.07.030
https://doi.org/10.1016/j.neuropharm.2012.07.030
Autor:
Derek J. Parks, Michael C. Lewis, Curt D. Haffner, Linda B. Moore, Stacey A. Jones, Adam M. Fivush, Timothy M. Willson, Kelli D. Plunket, Katrina L. Creech, Joan G. Wilson, Patrick R. Maloney, Gyan Chandra
Publikováno v:
Journal of Medicinal Chemistry. 43:2971-2974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730d2e2e1afcd2f2933aa2b93bd4d4b9
https://doi.org/10.1021/jm0002127
https://doi.org/10.1021/jm0002127
Autor:
Derek J. Parks, Tracey Smith-Oliver, Daniel D. Sternbach, Laura E. Wade, Paul S. Charifson, Peter Brown, Timothy M. Willson, Steven A. Kliewer, Nicholas C. O. Tomkinson, Steven G. Blanchard, Lisa A. Orband-Miller, Jürgen M. Lehmann, Adam M. Fivush
Publikováno v:
Chemistry & Biology. 4(12):909-918
Background: The peroxisome proliferator-activated receptors (PPARs) were cloned as orphan members of the nuclear receptor superfamily of transcription factors. The identification of subtype-selective ligands for PPARα and PPARγ has led to the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71052fba6d2f2a022f539e1e37910e68
Autor:
Adam M. Fivush, Timothy M. Willson
Publikováno v:
Tetrahedron Letters. 38:7151-7154
Oxidation of 4-(3-methoxy-4-hydroxymethylphenoxy)methyl polystyrene resin produced AMEBA resin 1 , a novel acid sensitive aldehyde resin. Reductive amination of AMEBA resin generated resin bound amines which were derivatized as sulfonamides, amides,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94262fda2b8c590e87de872fd42a5dda
https://doi.org/10.1016/s0040-4039(97)01771-1
https://doi.org/10.1016/s0040-4039(97)01771-1
Autor:
Millard H. Lambert, H. Eric Xu, Timothy M. Willson, Valerie G. Montana, Esther Y. Chao, Adam M. Fivush, Patrick R. Maloney, Curt D. Haffner, Marcos Luis Sznaidman, Christelle LeGrumelec, Michael Lawrence Sierra, William R. Oliver, Donna M. Goreham, Daniel D. Sternbach
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(9)
We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor delta (PPARdelta). Several hits were identified from our original libraries containing lipophilic carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8393b8fd9af7f9b199a09f382150c622
https://pubmed.ncbi.nlm.nih.gov/12699745
https://pubmed.ncbi.nlm.nih.gov/12699745
Autor:
Karl Whitney, Elizabeth J. Beaudet, Jane G Binz, Daniel G Morgan, Joan G. Wilson, Steven A. Kliewer, Tim K. Tippin, Jon L. Collins, Kelli D. Plunket, Michael C. Lewis, Timothy M. Willson, Cristin M. Galardi, Derek J. Parks, Michael A. Watson, Linda B. Moore, Adam M. Fivush
Publikováno v:
Journal of medicinal chemistry. 45(10)
A potent, selective, orally active LXR agonist was identified from focused libraries of tertiary amines. GW3965 (12) recruits the steroid receptor coactivator 1 to human LXRalpha in a cell-free ligand-sensing assay with an EC(50) of 125 nM and profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57450337574e6d092af6b86adf15bd0a
https://pubmed.ncbi.nlm.nih.gov/11985463
https://pubmed.ncbi.nlm.nih.gov/11985463