Functional replacement of myostatin with GDF-11 in the germline of mice

Autor: Se-Jin Lee, Adam Lehar, Renata Rydzik, Daniel W. Youngstrom, Shalender Bhasin, Yewei Liu, Emily L. Germain-Lee

Publikováno v: Skeletal Muscle, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Background Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal muscle mass. GDF-11, which is highly related to MSTN, plays multiple roles during embryonic development, including r

Externí odkaz: https://doaj.org/article/60da8f5624b74f10a475369fcd60a23e

Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway

Autor: Joshy George, Daniel W. Youngstrom, Martin M. Matzuk, Adam Lehar, Harshpreet Chandok, Yewei Liu, Renata Rydzik, Yun-Sil Lee, Se-Jin Lee, Emily L. Germain-Lee

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Maintenance of skeletal muscle and bone is regulated by key signaling proteins belonging to the transforming growth factor family. Here, we present genetic studies in mice showing that follistatin, which normally blocks the activities of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3231b2f7ee3d1578d938b34841045c
https://doi.org/10.1073/pnas.2111401118

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

Autor: Se-Jin Lee, Ivan Rattray, Agnesska C. Benjamin, Kirupa Sathasivam, Nelly Jolinon, Linda Greensmith, Andreas Neueder, Angela Richard-Londt, Donna L. Smith, Edward J. Smith, Gillian P. Bates, Adam Lehar, Mhoriam Ahmed, Tobias C. Wood, David Howland, Sebastian Brandner, Matthew Ellis, Hayley Lazell, Ignacio Munoz-Sanjuan, Marie K. Bondulich, James R. T. Dick, Nadira Ali, Xiaoli Chang, Georgina F. Osborne, Daniel Goodwin, Sophie A. Franklin, Linda Inuabasi, Jim Rosinski, Sarah J. Tabrizi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Bondulich, M K, Jolinon, N, Osborne, G F, Smith, E J, Rattray, I, Neueder, A, Sathasivam, K, Ahmed, M, Ali, N, Benjamin, A C, Chang, X, DIck, J R T, Ellis, M, Franklin, S A, Goodwin, D, Inuabasi, L, Lazell, H, Lehar, A, Richard-Londt, A, Rosinski, J, Smith, D L, Wood, T, Tabrizi, S J, Brandner, S, Greensmith, L, Howland, D, Munoz-Sanjuan, I, Lee, S J & Bates, G P 2017, ' Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice ', Scientific Reports, vol. 7, no. 1, 14275 . https://doi.org/10.1038/s41598-017-14290-3
Scientific Reports

Huntington’s disease (HD) is an inherited neurodegenerative disorder of which skeletal muscle atrophy is a common feature, and multiple lines of evidence support a muscle-based pathophysiology in HD mouse models. Inhibition of myostatin signaling i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f6f43fdc74a5fe622d6be346fa22b1
https://doi.org/10.1038/s41598-017-14290-3