Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Adam Lazorchak"'
Autor:
Feng Jiang, Hong Wang, Yan Lan, Guozhong Qin, Jin Qi, Bo Marelli, Huakui Yu, Kin-Ming Lo, Dong Zhang, Hui Huang, Hong Ma, Tsz-Lun Yeung, Ansgar A Wegener, Somdutta Saha, Mira Toister-Achituv, Molly H Jenkins, Li-Ya Chiu, Adam Lazorchak, Ohad Tarcic, George Locke, Doron Kalimi, Alec W Gross, Melissa G Derner, Maria Soloviev, Mathieu Botte, Aroop Sircar, Vanita D Sood
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Bintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized, simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1), within the tumor micro
Externí odkaz:
https://doaj.org/article/6670ff6236be4d8e8fdcf07fa04a27b4
Autor:
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, Mira Toister-Achituv, Molly H Jenkins, Li-Ya Chiu, Adam Lazorchak, Ohad Tarcic, Hong Wang, Jin Qi, George Locke, Doron Kalimi, Guozhong Qin, Bo Marelli, Huakui Yu, Alec W Gross, Melissa G Derner, Maria Soloviev, Mathieu Botte, Aroop Sircar, Hong Ma, Vanita D Sood, Dong Zhang, Feng Jiang, Kin-Ming Lo
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004122
BackgroundBintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized, simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1), within the tumor microe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f6ae2abf317f53e9d8f3c670958e3d
https://doi.org/10.1136/jitc-2021-004122
https://doi.org/10.1136/jitc-2021-004122
Autor:
Julian Schlegel, Mahmoud Moustafa, Katharina Kriegsmann, Katrin Rein, Jin Qi, Guozhong Qin, Cheng Zhou, Jennifer Furkel, Mark Kriegsmann, Amir Abdollahi, Maximilian Knoll, Feng Jiang, Sayed-Mohammad Hasheminasab, Adam Lazorchak, Juergen Debus, Chunxiao Xu, Rachel E. Fontana, Bo Marelli, Zili Tang, Damir Krunic, Yan Lan, George Locke, Carmen Klein, Molly H. Jenkins, Tsz-Lun Yeung, Huakui Yu, Sarah Meister, Kin-Ming Lo, Melissa G. Derner, Christian Schwager
Publikováno v:
Cancer Cell. 39:1388-1403.e10
Summary Localized radiotherapy (RT) induces an immunogenic antitumor response that is in part counterbalanced by activation of immune evasive and tissue remodeling processes, e.g., via upregulation of programmed cell death-ligand 1 (PD-L1) and transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9ce4655319e5c8e432661a57b50307
https://doi.org/10.1016/j.ccell.2021.08.008
https://doi.org/10.1016/j.ccell.2021.08.008
Publikováno v:
Cancer Research. 81:443-443
The targeting of pathways that regulate tumor angiogenesis is an effective strategy for the treatment of solid tumors. Transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF) are master regulators of tumor angiogenesis that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b3afa5c07e871c4a3e7cdba4d94b0a
https://doi.org/10.1158/1538-7445.am2021-443
https://doi.org/10.1158/1538-7445.am2021-443
Publikováno v:
Clinical Cancer Research. 27:PO-088
Ionizing radiation therapy (RT) is a standard of care for many cancer indications. RT promotes the activation of transforming growth factor (TGF)-β, a pleotropic cytokine that mediates RT-induced fibrosis and suppresses anti-tumor immunity. Addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a83dfa1f97a5dfbf006cbcea45edfc0
https://doi.org/10.1158/1557-3265.radsci21-po-088
https://doi.org/10.1158/1557-3265.radsci21-po-088
Autor:
Guozhong Qin, Jin Qi, Huakui Yu, Laureen S. Ojalvo, Tsz-Lun Yeung, George Locke, Bo Marelli, Isabelle Dussault, Alex Rolfe, Adam Lazorchak, Yan Lan, Molly H. Jenkins
Publikováno v:
Cancer Research. 80:1573-1573
Background: Bintrafusp alfa (M7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor, to function as a TGF-β “trap”, fused to a human IgG1 antibody blocking PD-L1, which has shown ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a81659a6a1b2d77b6445eb884da806c
https://doi.org/10.1158/1538-7445.am2020-1573
https://doi.org/10.1158/1538-7445.am2020-1573