Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Adam Lavertu"'
Autor:
Violette Gijsen, Michele Maddux, Adam Lavertu, Graciela Gonzalez‐Hernandez, Nilam Ram, Byron Reeves, Thomas Robinson, Victoria Ziesenitz, Valentina Shakhnovich, Russ Altman
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 26-30 (2020)
Electronic communication is becoming increasingly popular worldwide, as evidenced by its widespread and rapidly growing use. In medicine, however, it remains a novel approach to reach out to patients. Yet, they have the potential for further improvin
Externí odkaz:
https://doaj.org/article/553b5004418447e9bef68ed544427e6a
Autor:
Michael L. Cato, Hallie D. Jester, Adam Lavertu, Audrey Lyman, Lacey M. Tallent, Geoffrey C. Mitchell
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3843-3853 (2019)
A delicate relationship exists between reef-building corals and their photosynthetic endosymbionts. Unfortunately, this relationship can be disrupted, with corals expelling these algae when temperatures rise even marginally above the average summer m
Externí odkaz:
https://doaj.org/article/9dd3e5cd28bb4bd5ad398b13c24bb25e
Publikováno v:
Journal of Medical Internet Research, Vol 23, Iss 10, p e27714 (2021)
BackgroundAdverse drug reactions (ADRs) affect the health of hundreds of thousands of individuals annually in the United States, with associated costs of hundreds of billions of dollars. The monitoring and analysis of the severity of ADRs is limited
Externí odkaz:
https://doaj.org/article/ca8a09a31f6a48d78e0c4db14fdd84ea
Autor:
David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Publikováno v:
eLife, Vol 8 (2019)
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://doaj.org/article/f8b0b64eb9da49ff8b1b2ae4b6712fa1
Autor:
Christopher DeBoever, Yosuke Tanigawa, Malene E. Lindholm, Greg McInnes, Adam Lavertu, Erik Ingelsson, Chris Chang, Euan A. Ashley, Carlos D. Bustamante, Mark J. Daly, Manuel A. Rivas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Protein-truncating variants (PTVs) are predicted to significantly affect a gene’s function and, thus, human traits. Here, DeBoever et al. systematically analyze PTVs in more than 300,000 individuals across 135 phenotypes and identify 27 association
Externí odkaz:
https://doaj.org/article/4ce5ec51846e458aa6a36cea259e640a
Autor:
Simon Lalonde, Oliver A Stone, Samuel Lessard, Adam Lavertu, Jessica Desjardins, Mélissa Beaudoin, Manuel Rivas, Didier Y R Stainier, Guillaume Lettre
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178700 (2017)
The introduction of frameshift indels by genome editing has emerged as a powerful technique to study the functions of uncharacterized genes in cell lines and model organisms. Such mutations should lead to mRNA degradation owing to nonsense-mediated m
Externí odkaz:
https://doaj.org/article/1a33658a753544a1839021af69869ef6
Publikováno v:
Clinical Pharmacology and Therapeutics
Adverse drug reactions (ADRs) are a major concern for patients, clinicians, and regulatory agencies. The discovery of serious ADRs leading to substantial morbidity and mortality has resulted in mandatory phase IV clinical trials, black box warnings,
Autor:
Manuel A. Rivas, Greg McInnes, Matthew Aguirre, Yosuke Tanigawa, Adam Lavertu, Christopher DeBoever
Publikováno v:
Am J Hum Genet
Population-scale biobanks that combine genetic data and high-dimensional phenotyping for a large number of participants provide an exciting opportunity to perform genome-wide association studies (GWAS) to identify genetic variants associated with div
Autor:
Lester G. Carter, Adam Lavertu, Anurag Verma, Michelle Whirl-Carrillo, Marylyn D. Ritchie, Teri E. Klein, Ryan Whaley, Russ B. Altman, Mark Woon, Katrin Sangkuhl
Publikováno v:
Clinical Pharmacology and Therapeutics
Pharmacogenomics (PGx) decision support and return of results is an active area of precision medicine. One challenge of implementing PGx is extracting genomic variants and assigning haplotypes in order to apply prescribing recommendations and informa
Autor:
Valentina Shakhnovich, Violette Gijsen, Victoria C. Ziesenitz, Byron Reeves, Russ B. Altman, Graciela Gonzalez-Hernandez, Adam Lavertu, Nilam Ram, Thomas N. Robinson, Michele H Maddux
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 13, Iss 1, Pp 26-30 (2020)
Clinical and Translational Science, Vol 13, Iss 1, Pp 26-30 (2020)
Electronic communication is becoming increasingly popular worldwide, as evidenced by its widespread and rapidly growing use. In medicine, however, it remains a novel approach to reach out to patients. Yet, they have the potential for further improvin