Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Adam Lauko"'
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Wesley Wang, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Prajwal Rajappa, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment respon
Externí odkaz:
https://doaj.org/article/235cfdd3465841ec8a0ca9c96d6c14cb
Autor:
Adam Lauko, Rupesh Kotecha, Addison Barnett, Hong Li, Vineeth Tatineni, Assad Ali, Pradnya Patil, Alireza M. Mohammadi, Samuel T. Chao, Erin S. Murphy, Lilyana Angelov, John H. Suh, Gene H. Barnett, Nathan A. Pennell, Manmeet S. Ahluwalia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Immune checkpoint inhibitors (ICIs) have resulted in improved outcomes in non-small cell lung cancer (NSCLC) patients. However, data demonstrating the efficacy of ICIs in NSCLC brain metastases (NSCLCBM) is limited. We analyzed overall survi
Externí odkaz:
https://doaj.org/article/e1027f0afb7f466d803752a48a7d5614
Autor:
Adam Lauko, Bicky Thapa, Mayur Sharma, Baha’eddin Muhsen, Addison Barnett, Yasmeen Rauf, Hamid Borghei-Razavi, Vineeth Tatineni, Pradnya Patil, Alireza Mohammadi, Samuel Chao, Erin S. Murphy, Lilyana Angelov, John Suh, Gene H. Barnett, Amy S. Nowacki, Nathan Pennell, Manmeet S. Ahluwalia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Steroids are often utilized to manage patients with non-small cell lung cancer brain metastases (NSCLCBM). Steroids and elevated neutrophil-to-lymphocyte ratio (NLR) have been associated with decreased overall survival (OS) in patients treat
Externí odkaz:
https://doaj.org/article/f4dcac47865a41d3946306192c5da152
Autor:
Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 107-107 (2023)
OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify
Externí odkaz:
https://doaj.org/article/38b0f34846504b9fac37c7e24f076612
Autor:
Tyler J. Alban, Defne Bayik, Balint Otvos, Anja Rabljenovic, Lin Leng, Leu Jia-Shiun, Gustavo Roversi, Adam Lauko, Arbaz A. Momin, Alireza M. Mohammadi, David M. Peereboom, Manmeet S. Ahluwalia, Kazuko Matsuda, Kyuson Yun, Richard Bucala, Michael A. Vogelbaum, Justin D. Lathia
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The application of tumor immunotherapy to glioblastoma (GBM) is limited by an unprecedented degree of immune suppression due to factors that include high numbers of immune suppressive myeloid cells, the blood brain barrier, and T cell sequestration t
Externí odkaz:
https://doaj.org/article/b0517335ef4c4e3faf3230da1829efe0
Autor:
Adam Lauko, Rupesh Kotecha, Addison Barnett, Hong Li, Vineeth Tatineni, Assad Ali, Pradnya Patil, Alireza M. Mohammadi, Samuel T. Chao, Erin S. Murphy, Lilyana Angelov, John H. Suh, Gene H. Barnett, Nathan A. Pennell, Manmeet S. Ahluwalia
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/92e15452fa0f49b386931b922b83062a
Autor:
Adam Lauko, Bicky Thapa, Mayur Sharma, Baha’eddin A. Muhsen, Addison Barnett, Yasmeen Rauf, Hamid Borghei-Razavi, Vineeth Tatineni, Pradnya Patil, Alireza Mohammadi, Samuel Chao, Erin S. Murphy, Lilyana Angelov, John Suh, Gene H. Barnett, Amy S. Nowacki, Nathan Pennell, Manmeet S. Ahluwalia
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/df6435edefc94c44bbfde69263a976a3
Autor:
Adam Lauko, Bicky Thapa, Mayur Sharma, Baha’eddin A. Muhsen, Addison Barnett, Yasmeen Rauf, Hamid Borghei‑Razavi, Vineeth Tatineni, Pradnya Patil, Alireza Mohammadi, Samuel Chao, Erin S. Murphy, Lilyana Angelov, John Suh, Gene H. Barnett, Amy S. Nowacki, Nathan Pennell, Manmeet S. Ahluwalia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/a7690529a2fa47338170d5e9edcffcf4
Autor:
Dionysios C. Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A. Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R. Lunavat, Daniel J. Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi Deshpande, Joris Guyon, Yadi Zhou, Capucine R. Magaut, Juliana Seder, Laura Neises, Sarah E. Williford, Johannes Meiser, Andrew J. Scott, Peter Sajjakulnukit, Jason A. Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas A. Lyssiotis, Daniel R. Wahl, Anita B. Hjelmeland, Jubayer A. Hossain, Hrvoje Miletic, Justin D. Lathia
Publikováno v:
Nature Cancer. 4:648-664
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood. Here we show that mit
Autor:
Kelly Mitchell, Samuel A. Sprowls, Sonali Arora, Sajina Shakya, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel E. Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, Jonathan D'Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Eric C. Holland, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Genes & Development. 37:86-102
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We develo