Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adam L. Hughes"'
Autor:
Nadav Shai, Eden Yifrach, Carlo W. T. van Roermund, Nir Cohen, Chen Bibi, Lodewijk IJlst, Laetitia Cavellini, Julie Meurisse, Ramona Schuster, Lior Zada, Muriel C. Mari, Fulvio M. Reggiori, Adam L. Hughes, Mafalda Escobar-Henriques, Mickael M. Cohen, Hans R. Waterham, Ronald J. A. Wanders, Maya Schuldiner, Einat Zalckvar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The internal organization of the cell has been enriched by the discovery that organelles establish membrane contact sites, however the entire repertoire of these contacts is still being explored. Here the authors systematically identify the landscape
Externí odkaz:
https://doaj.org/article/2dc37c819f6140ea903c97bd975857d0
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 9, Pp 2001-2012 (2008)
The endoplasmic reticulum membrane protein SREBP cleavage-activating protein (Scap) senses sterols and regulates activation of sterol-regulatory element binding proteins (SREBPs), membrane-bound transcription factors that control lipid homeostasis in
Externí odkaz:
https://doaj.org/article/d7d602712d0743f799bcfdec6e3c1fa5
Autor:
Viplendra PS Shakya, William A Barbeau, Tianyao Xiao, Christina S Knutson, Max H Schuler, Adam L Hughes
Publikováno v:
eLife, Vol 10 (2021)
Mitochondrial import deficiency causes cellular toxicity due to the accumulation of non-imported mitochondrial precursor proteins, termed mitoprotein-induced stress. Despite the burden mis-localized mitochondrial precursors place on cells, our unders
Externí odkaz:
https://doaj.org/article/6fa52855a2574c56a02283654cb85a14
Autor:
Troy K Coody, Adam L Hughes
Publikováno v:
eLife, Vol 7 (2018)
A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research.
Externí odkaz:
https://doaj.org/article/626b34a3365c4541afc74c2cb255345c
Autor:
Adam L. Hughes
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51e6200c07dd8c116ac14672bf5d1fba
https://doi.org/10.1096/fasebj.2022.36.s1.0i171
https://doi.org/10.1096/fasebj.2022.36.s1.0i171
Autor:
Max-Hinderk Schuler, Adam L. Hughes
Publikováno v:
Molecular cell. 82(6)
Li et al. (2022) discover that Toxoplasma infection triggers remodeling of the mitochondrial outer membrane through generation of a mitochondrial subdomain termed "structure positive for outer mitochondrial membrane" (SPOT).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8978191539ffb3c4682c20c39d508e
https://pubmed.ncbi.nlm.nih.gov/35025629
https://pubmed.ncbi.nlm.nih.gov/35025629
Publikováno v:
eLife, Vol 5 (2016)
Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial proteome or alter mitochondrial content during time
Externí odkaz:
https://doaj.org/article/58fd680ae64c4870a87c5060d7aa9b6e
Fission yeast Dap1 is a membrane-bound, heme binding protein that binds directly to both fission yeast cytochromes P450, Erg5 and Erg11, and is required for Erg5 and Erg11 function in ergosterol synthesis (Hughes et al., 2007). Progesterone receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a51d415dabe4fee89dadb0d84b6cd9
Publikováno v:
eLife, Vol 3 (2014)
Replicative aging in yeast is asymmetric–mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother
Externí odkaz:
https://doaj.org/article/97925d28da9a49f9a1821bca0d06b3fc
Publikováno v:
Ageing research reviews. 32
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including responses to nutrient availability and composition, stress resistance, programmed cell death, plasma membrane repair, develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2dad46c085158385565df793308281a8
https://pubmed.ncbi.nlm.nih.gov/27125853
https://pubmed.ncbi.nlm.nih.gov/27125853