Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Adam L. Halberstadt"'
Autor:
Jason Wallach, Andrew B. Cao, Maggie M. Calkins, Andrew J. Heim, Janelle K. Lanham, Emma M. Bonniwell, Joseph J. Hennessey, Hailey A. Bock, Emilie I. Anderson, Alexander M. Sherwood, Hamilton Morris, Robbin de Klein, Adam K. Klein, Bruna Cuccurazzu, James Gamrat, Tilka Fannana, Randy Zauhar, Adam L. Halberstadt, John D. McCorvy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT2A-Gq/11 and β-arrestin2 transducers, making their respectiv
Externí odkaz:
https://doaj.org/article/30bf5d9d5f33452682a561177a856eb2
Autor:
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107121- (2023)
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arre
Externí odkaz:
https://doaj.org/article/fc293bbf9b694c2ca0a05e1bba69bdbb
Autor:
Vern Lewis, Emma M. Bonniwell, Janelle K. Lanham, Abdi Ghaffari, Hooshmand Sheshbaradaran, Andrew B. Cao, Maggie M. Calkins, Mario Alberto Bautista-Carro, Emily Arsenault, Andre Telfer, Fatimeh-Frouh Taghavi-Abkuh, Nicholas J. Malcolm, Fatema El Sayegh, Alfonso Abizaid, Yasmin Schmid, Kathleen Morton, Adam L. Halberstadt, Argel Aguilar-Valles, John D. McCorvy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112203- (2023)
Summary: Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-cou
Externí odkaz:
https://doaj.org/article/2c21b545191b4d11912819fd72041816
Autor:
Pierce V. Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Alexander Stratford, Volker Auwärter, Stephen J. Chapman, Adam L. Halberstadt, Simon D. Brandt
Publikováno v:
Drug Testing and Analysis. 15:277-291
The development of novel lysergamides continues to occur, based on both the needs of psychedelic medicine and commercial interest in new recreational substances. The present study continues the authors' research on novel lysergamides and describes th
Autor:
Jared W. Young, Arpi Minassian, Benjamin Z Roberts, Adam L. Halberstadt, Yinong V He, Muhammad Chatha, Igor Grant, Mark A. Geyer
Publikováno v:
International Journal of Neuropsychopharmacology
Background HIV-associated neurocognitive disorder (HAND) is commonly observed in persons living with HIV (PWH) and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also susceptible to
Publikováno v:
J Nat Prod
A novel analogue of psilocybin was produced by hybrid chemoenzymatic synthesis in sufficient quantity to enable bioassay. Utilizing purified 4-hydroxytryptamine kinase from Psilocybe cubensis, chemically synthesized 5-methylpsilocin (2) was enzymatic
Autor:
Adam L. Halberstadt, Stephen J. Chapman, Simon D. Brandt, Muhammad Chatha, Emilie I. Anderson, Lauren J. Laskowski, John D. McCorvy, Adam K. Klein
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The 5-HT(2A) receptor is thought to be the primary target for psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and other serotonergic hallucinogens (psychedelic drugs). Although a large amount of experimental work has been conduc
Autor:
Adam L. Halberstadt, Dino Luethi, Marius C. Hoener, Daniel Trachsel, Simon D. Brandt, Matthias E. Liechti
Publikováno v:
Psychopharmacology, vol 240, iss 1
Rationale 4-Thio-substituted phenylalkylamines such as 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2) and 2,5-dimethoxy-4-n-propylthiophenethylamine (2C-T-7) produce psychedelic effects in humans and have been distributed as recreational drugs. Obj
Autor:
Jason Wallach, Heather Kang, Tristan Colestock, Hamilton Morris, Zuner A Bortolotto, Graham L Collingridge, David Lodge, Adam L Halberstadt, Simon D Brandt, Adeboye Adejare
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157021 (2016)
1,2-Diarylethylamines including lanicemine, lefetamine, and remacemide have clinical relevance in a range of therapeutic areas including pain management, epilepsy, neurodegenerative disease and depression. More recently 1,2-diarylethylamines have bee
Externí odkaz:
https://doaj.org/article/e97ed5f9486741bebd14a1590aad934e
Autor:
David Dupuis, Adam L. Halberstadt, Philip R. Corlett, Martin Fortier-Davy, Frank Larøi, Katrin H. Preller, Flavie Waters, Yuliya Zaytseva, Pantelis Leptourgos, Renaud Jardri, Eva Kozáková, Robin L. Carhart-Harris, Tehseen Noorani, Michael Kometer
Publikováno v:
Schizophrenia bulletin, vol 46, iss 6
Schizophrenia Bulletin
Schizophrenia bulletin, 2020, Vol.46(6), pp.1396-1408 [Peer Reviewed Journal]
Schizophrenia Bulletin
Schizophrenia bulletin, 2020, Vol.46(6), pp.1396-1408 [Peer Reviewed Journal]
The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary workin