Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Adam L. Burrack"'
Autor:
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which
Externí odkaz:
https://doaj.org/article/f686ccd3ae77471d8e50f4e9b637e5d1
Autor:
Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112732- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, b
Externí odkaz:
https://doaj.org/article/9c8f1bd7911f4300864de0884a707a9f
Autor:
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1 dendritic cel
Externí odkaz:
https://doaj.org/article/78e01ca8e9fd4f30a7edc6e8a733121d
Autor:
Ronald G. Gill, Adam L. Burrack
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Memory T lymphocytes constitute a significant problem in tissue and organ transplantation due their contribution to early rejection and their relative resistance to tolerance-promoting therapies. Memory cells generated by environmental antigen exposu
Externí odkaz:
https://doaj.org/article/79ea995a83354d1684419f80bfb936c7
Autor:
Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2140-2155.e6 (2019)
Summary: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is required for intratumoral T cell accumulation and response to immune checkpoint blockade
Externí odkaz:
https://doaj.org/article/432579c464ba4028af08cb056171821b
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the immune system. Despite improvements in insulin analogs and continuous blood glucose level monitoring, there is no cure for T1D, and some individuals develop lif
Externí odkaz:
https://doaj.org/article/c22e5c1788524e34916c9959360c6896
Autor:
Philip D Greenberg, Patrick Bonson, Sunil R Hingorani, Ayaka Hulbert, Meagan R Rollins, Ryan S Basom, Jeffrey Delrow, Adam L Burrack
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Achieving robust responses with adoptive cell therapy for the treatment of the highly lethal pancreatic ductal adenocarcinoma (PDA) has been elusive. We previously showed that T cells engineered to express a mesothelin-specific T cell rece
Externí odkaz:
https://doaj.org/article/0ce5efbe9025488eb29b3b4f114e582e
Autor:
Adam L. Burrack, Ellen J. Spartz, Meagan R. Rollins, Ebony A. Miller, Maria Firulyova, Eduardo Cruz, Michael F. Goldberg, Iris X. Wang, Hezkiel Nanda, Steven Shen, Konstantin Zaitsev, Ingunn M. Stromnes
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1461-1478
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells differentiate and are maintained in vivo could inform novel therapeutic avenues to promote T cell ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a800b3a2978443d4dca76a444b603707
https://doi.org/10.1007/s00262-022-03338-7
https://doi.org/10.1007/s00262-022-03338-7
Autor:
Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, Ingunn M. Stromnes
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3889d98b8d31697f6a7b46d07e3a0c8
https://doi.org/10.1158/2326-6066.22542532
https://doi.org/10.1158/2326-6066.22542532
Autor:
Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, Ingunn M. Stromnes
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapies, including immune-checkpoint blockade. We investigated two distinct strategies to modulate tumor-associated macrophages (TAM) to enhance cellular therapy targeting m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090cc78bd1afb4f777552df268a76f6b
https://doi.org/10.1158/2326-6066.c.6549967.v1
https://doi.org/10.1158/2326-6066.c.6549967.v1