Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Adam L Borne"'
Autor:
Anthony M. Ciancone, Kyung W. Seo, Miaomiao Chen, Adam L. Borne, Adam H. Libby, Dina L. Bai, Ralph E. Kleiner, Ku-Lung Hsu
Publikováno v:
Journal of the American Chemical Society. 145:11056-11066
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a665d6399d403dcc351fb4cfb9c1d44
https://doi.org/10.1021/jacs.3c00165
https://doi.org/10.1021/jacs.3c00165
Autor:
Ku-Lung Hsu, Heather A. Ferris, Jeffrey W. Brulet, Mitchell E. Granade, Thurl E. Harris, Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne
Publikováno v:
Chemical Science
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of SuTEx chemistry f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf7e33426ec572ae52cc64d0e7dc2ed
https://doi.org/10.1039/d0sc06623k
https://doi.org/10.1039/d0sc06623k
Publikováno v:
RSC chemical biology
Sulfur electrophiles constitute an important class of covalent small molecules that have found widespread applications in synthetic chemistry and chemical biology. Various electrophilic scaffolds, including sulfonyl fluorides and arylfluorosulfates a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658bfd4478c7452de836220d74385a63
https://doi.org/10.1039/d0cb00180e
https://doi.org/10.1039/d0cb00180e
Publikováno v:
J Am Chem Soc
Tuning reactivity of sulfur electrophiles is key for advancing click chemistry and chemical probe discovery. To date, activation of the sulfur electrophile for protein modification has been ascribed principally to stabilization of a fluoride leaving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b3686a69d8616a4d70bca31dfdbd0a
https://doi.org/10.1021/jacs.0c00648
https://doi.org/10.1021/jacs.0c00648
Autor:
Anthony M. Ciancone, Seyyedmohsen Hosseinibarkooie, Dina L. Bai, Adam L. Borne, Heather A. Ferris, Ku-Lung Hsu
Publikováno v:
Cell Chemical Biology. 29:1709-1720.e7
RNA granules are cytoplasmic condensates that organize biochemical and signaling complexes in response to cellular stress. Functional proteomic investigations under RNA-granule-inducing conditions are needed to identify protein sites involved in coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd6c42065047b3ea7e4c9ecdb59998
https://doi.org/10.1016/j.chembiol.2022.11.008
https://doi.org/10.1016/j.chembiol.2022.11.008
Autor:
Jeffrey W. Brulet, Emmanuel K. Toroitich, Adam L. Borne, Ku-Lung Hsu, Adam H. Libby, Kun Yuan, Rebecca L. McCloud, Heung Sik Hahm, Anthony M. Ciancone, Timothy B. Ware
Publikováno v:
Nature chemical biology
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g. cysteine and lysine), a large fraction of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e67754184c57e1858402514e5bc77d0
https://doi.org/10.1038/s41589-019-0404-5
https://doi.org/10.1038/s41589-019-0404-5
Autor:
Jae-Young Kim, Paul A. Stewart, Adam L. Borne, Bin Fang, Eric A. Welsh, Yian Ann Chen, Steven A. Eschrich, John M. Koomen, Eric B. Haura
Publikováno v:
Proteomes, Vol 4, Iss 2, p 16 (2016)
One way cancer cells can escape from targeted agents is through their ability to evade drug effects by rapidly rewiring signaling networks. Many protein classes, such as kinases and metabolic enzymes, are regulated by ATP binding and hydrolysis. We h
Externí odkaz:
https://doaj.org/article/57256ec4d482404a97ced0655e30fc7a
Autor:
Ku-Lung Hsu, Adam L Borne, Jeffrey W Brulet, Heung S Hahm, Emmanuel K Toroitich, Adam H Libby, Kun Yuan, Timothy B Ware, Rebecca L McCloud, Anthony M Ciancone
Publikováno v:
The Journal of Immunology. 204:159.44-159.44
Chemoproteomic probes serve as valuable tools to study and perturb protein function on a global scale. Despite advances in methodologies for cysteine and lysine profiling, a large fraction of the human proteome remains inaccessible with current activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46d1fc4fdd7a6d0a9359204ba24566d
https://doi.org/10.4049/jimmunol.204.supp.159.44
https://doi.org/10.4049/jimmunol.204.supp.159.44
Autor:
Liuzhi Zhang, Ku-Lung Hsu, Adam L. Borne, Myungsun Shin, Caroline E. Franks, Sean T. Campbell
Ritanserin was tested in the clinic as a serotonin receptor inverse agonist but recently emerged as a novel kinase inhibitor with potential applications in cancer. Here, we discovered that ritanserin induced apoptotic cell death of non-small cell lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6787511f8f58fb7db2ed150520242f44
https://europepmc.org/articles/PMC6160665/
https://europepmc.org/articles/PMC6160665/
Autor:
Adam L. Borne, Tao Huang, Rebecca L. McCloud, Ku-Lung Hsu, Boobalan Pachaiyappan, Timothy N. J. Bullock
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030111427
As a major sentinel of adaptive immunity, T cells seek and destroy diseased cells using antigen recognition to achieve molecular specificity. Strategies to block checkpoint inhibition of T cell activity and thus reawaken the patient's antitumor immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b525c24617d32cb95e9813818980fc8c
https://pubmed.ncbi.nlm.nih.gov/30128827
https://pubmed.ncbi.nlm.nih.gov/30128827