Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Adam Kraszewski"'
Autor:
Merchant, John
Publikováno v:
Slavic Review, 2018 Apr 01. 77(1), 235-236.
Externí odkaz:
https://www.jstor.org/stable/26565373
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
In this review a short account of our work on the synthesis and biological activity of electrically neutral and charged anti-HIV and anticancer pronucleotides, presented on the background of the contemporary research in this area, is given.
Externí odkaz:
https://doaj.org/article/5fa079c2d7974525a1bf7f446e2dd878
Autor:
Joanna Romanowska, Justyna Gołębiewska, Michal Sobkowski, Krystian Kolodziej, Tomasz Jakubowski, Marta Rachwalak, Jerzy Boryski, Aleksandra Dabrowska, Adam Kraszewski, Jacek Stawinski
Publikováno v:
European Journal of Medicinal Chemistry. 164:47-58
We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pronucleotides. Depending o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4708d049c559aac488e3aa03cb1d84f
https://doi.org/10.1016/j.ejmech.2018.12.038
https://doi.org/10.1016/j.ejmech.2018.12.038
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry
Frontiers in Chemistry
In this review a short account of our work on the synthesis and biological activity of electrically neutral and charged anti-HIV and anticancer pronucleotides, presented on the background of the contemporary research in this area, is given.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e125d6adcd7fc0ca397a3884a4d8d07
https://doi.org/10.3389/fchem.2020.595738
https://doi.org/10.3389/fchem.2020.595738
Autor:
Dariusz Wawrzyniak, Agnieszka Szymanska-Michalak, Adam Kraszewski, Jan Barciszewski, Jerzy Boryski, Paulina Zgoła, Marta Kujda, Grzegorz Framski, Jacek Stawinski
Publikováno v:
European Journal of Medicinal Chemistry. 115:41-52
New aromatic and aliphatic 3'-O-acyl-5-fluoro-2'-deoxyuridine derivatives were synthesized and evaluated as candidates for prodrugs against various cancer cell lines. As the most promising candidate for antimalignant therapeutics was found a dual-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fc9b914cd8d74c991a94ba17dc46b1
https://doi.org/10.1016/j.ejmech.2016.03.010
https://doi.org/10.1016/j.ejmech.2016.03.010
Publikováno v:
Analytical and Bioanalytical Chemistry
Nucleotides, their analogues, and other phosphate esters and phosphoramidates often contain the triethylammonium cation as a counterion. We found that this may be lost during chromatographic purification or concentration of solutions, yielding produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca21d40a49b813b10b69eb8c327872d6
http://europepmc.org/articles/PMC4329187
http://europepmc.org/articles/PMC4329187
Autor:
Jan Barciszewski, Adam Kraszewski, Jacek Stawinski, Dariusz Wawrzyniak, Grzegorz Framski, Agnieszka Szymanska-Michalak
Publikováno v:
European journal of medicinal chemistry. 144
We have designed and synthesized new 5-fluoro-2′-deoxyuridine 5′-phosphate pronucleotides which can function as potential agents against the glioblastoma multiforme tumor. Their anti-malignant potency has been tested against T98G, U-118 MG, U-87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56e504247e03b71460b5aa701e26f9e
https://pubmed.ncbi.nlm.nih.gov/29289891
https://pubmed.ncbi.nlm.nih.gov/29289891
Autor:
Jan Barciszewski, Jacek Stawinski, Dariusz Wawrzyniak, Agnieszka Szymanska-Michalak, Adam Kraszewski, Zofia Jahnz-Wechmann, Jerzy Boryski, Grzegorz Framski
Publikováno v:
Acta Biochimica Polonica. 63
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc3dbb427e1e798363cee0c3bcef5f0
https://doi.org/10.18388/abp.2016_1338
https://doi.org/10.18388/abp.2016_1338
Publikováno v:
ChemInform. 47
This review covers recent progress in the preparation of H-phosphonate mono- and diesters, basic studies on mechanistic and stereochemical aspects of this class of phosphorus compounds, and their fundamental chemistry in terms of transformation of P-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9751390158ddf79aef518283a200311a
https://doi.org/10.1002/chin.201652436
https://doi.org/10.1002/chin.201652436
Publikováno v:
ChemInform. 47
This chapter provides an overview of recent advances in the development of new methods and protocols for the formation of the P-C bond using H-phosphonate diesters as starting materials. Various chemical and stereochemical aspects of the transition m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375cc6f22f2910ec8e8c5cf64123ed47
https://doi.org/10.1002/chin.201651273
https://doi.org/10.1002/chin.201651273