Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Adam Kim"'
Autor:
Adam Kim, Martí Ortega-Ribera, Megan R. McMullen, Annette Bellar, Moyinoluwa Taiwo, Vai Pathak, David Streem, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, Vidula Vachharajani, Laura E. Nagy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107133- (2023)
Summary: Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular me
Externí odkaz:
https://doaj.org/article/d98479cccd364976b87e0478ee4d52c3
Autor:
Xiude Fan, Jianguo Wu, Kyle L. Poulsen, Adam Kim, Xiaoqin Wu, Emily Huang, Tatsunori Miyata, Carlos Sanz‐Garcia, Laura E. Nagy
Publikováno v:
Hepatology Communications, Vol 5, Iss 5, Pp 830-845 (2021)
We aimed to identify a microRNA (miRNA)‐E3 ubiquitin ligase regulatory network for protein substrates enriched in cell death pathways and investigate the underlying molecular mechanisms in alcohol‐associated hepatitis (AH). An miRNA‐E3 ubiquiti
Externí odkaz:
https://doaj.org/article/f58c98a8f50e47dcaa605cccdf145872
Publikováno v:
Hepatology Communications, Vol 4, Iss 10, Pp 1459-1476 (2020)
Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate the liver, leading to nonresolving inflammation and injury. Single‐cell RNA sequencing
Externí odkaz:
https://doaj.org/article/ccb295b2c4a54038ba2e6a863ab3d2e0
Autor:
Robert N Helsley, Tatsunori Miyata, Anagha Kadam, Venkateshwari Varadharajan, Naseer Sangwan, Emily C Huang, Rakhee Banerjee, Amanda L Brown, Kevin K Fung, William J Massey, Chase Neumann, Danny Orabi, Lucas J Osborn, Rebecca C Schugar, Megan R McMullen, Annette Bellar, Kyle L Poulsen, Adam Kim, Vai Pathak, Marko Mrdjen, James T Anderson, Belinda Willard, Craig J McClain, Mack Mitchell, Arthur J McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Jose Carlos Garcia-Garcia, Daniel M Rotroff, Daniela S Allende, Zeneng Wang, Stanley L Hazen, Laura E Nagy, Jonathan Mark Brown
Publikováno v:
eLife, Vol 11 (2022)
There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including the most deadly form known as alcohol-associated hepatitis (AH). However, mechanisms by which gut microbe
Externí odkaz:
https://doaj.org/article/9d2e1ecd214249d6a556320886d84ab0
Autor:
Juliana M. Sá, Sarah R. Kaslow, Roberto R. Moraes Barros, Nicholas F. Brazeau, Christian M. Parobek, Dingyin Tao, Rebecca E. Salzman, Tyler J. Gibson, Soundarapandian Velmurugan, Michael A. Krause, Viviana Melendez-Muniz, Whitney A. Kite, Paul K. Han, Richard T. Eastman, Adam Kim, Evan G. Kessler, Yonas Abebe, Eric R. James, Sumana Chakravarty, Sachy Orr-Gonzalez, Lynn E. Lambert, Theresa Engels, Marvin L. Thomas, Pius S. Fasinu, David Serre, Robert W. Gwadz, Larry Walker, Derrick K. DeConti, Jianbing Mu, Jeffrey A. Bailey, B. Kim Lee Sim, Stephen L. Hoffman, Michael P. Fay, Rhoel R. Dinglasan, Jonathan J. Juliano, Thomas E. Wellems
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.
Externí odkaz:
https://doaj.org/article/d2e5b78b5b7d41ea85f525fdaf910313
Autor:
Nathan A. Snyder, Adam Kim, Louis Kester, Andrew N. Gale, Christian Studer, Dominic Hoepfner, Silvio Roggo, Stephen B. Helliwell, Kyle W. Cunningham
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 829-840 (2019)
Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cel
Externí odkaz:
https://doaj.org/article/3c656557bb5648078cf2ced79446adef
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Plasmodium vivax biology is not well understood, due to a lack of in vitro culture systems and difficulties associated with studying clinical blood samples. Here, Kim et al. use gene expression profiles from P. vivax infected patient blood and show s
Externí odkaz:
https://doaj.org/article/dd68ed0408f6443b81edead0762457ba
Autor:
Nathan A. Snyder, Christopher P. Stefan, Camille T. Soroudi, Adam Kim, Carlos Evangelista, Kyle W. Cunningham
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 12, Pp 3913-3924 (2017)
Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H+) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and
Externí odkaz:
https://doaj.org/article/892216a29abd43f2a3e13a43633bbd9f
Autor:
Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo-Herrera, Didier Ménard, David Serre
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically displ
Externí odkaz:
https://doaj.org/article/cec4e837a2a7481f9b1cc28fd298bd6f