Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam K. Savage"'
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T. Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively
Externí odkaz:
https://doaj.org/article/9167378588ad444cbf7f985a5e41ce2a
Autor:
Adam K. Savage, Miriam V. Gutschow, Tony Chiang, Kathy Henderson, Richard Green, Monica Chaudhari, Elliott Swanson, Alexander T. Heubeck, Nina Kondza, Kelli C. Burley, Palak C. Genge, Cara Lord, Tanja Smith, Zachary Thomson, Aldan Beaubien, Ed Johnson, Jeff Goldy, Hamid Bolouri, Jane H. Buckner, Paul Meijer, Ernest M. Coffey, Peter J. Skene, Troy R. Torgerson, Xiao-jun Li, Thomas F. Bumol
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102404- (2021)
Summary: Multi-omic profiling of human peripheral blood is increasingly utilized to identify biomarkers and pathophysiologic mechanisms of disease. The importance of these platforms in clinical and translational studies led us to investigate the impa
Externí odkaz:
https://doaj.org/article/a1e55c9d0af740fea6a687681949f26b
Autor:
Jenna M. Kastenschmidt, Gerald Coulis, Philip K. Farahat, Phillip Pham, Rodolfo Rios, Therese T. Cristal, Ali H. Mannaa, Rachel E. Ayer, Rayan Yahia, Archis A. Deshpande, Brandon S. Hughes, Adam K. Savage, Carlee R. Giesige, Scott Q. Harper, Richard M. Locksley, Tahseen Mozaffar, S. Armando Villalta
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108997- (2021)
Summary: Despite the well-accepted view that chronic inflammation contributes to the pathogenesis of Duchenne muscular dystrophy (DMD), the function and regulation of eosinophils remain an unclear facet of type II innate immunity in dystrophic muscle
Externí odkaz:
https://doaj.org/article/415bf515be5348feade1d4581741b4f9
Autor:
Elliott Swanson, Cara Lord, Julian Reading, Alexander T Heubeck, Palak C Genge, Zachary Thomson, Morgan DA Weiss, Xiao-jun Li, Adam K Savage, Richard R Green, Troy R Torgerson, Thomas F Bumol, Lucas T Graybuck, Peter J Skene
Publikováno v:
eLife, Vol 10 (2021)
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease. Recent advances have allowed paired capture of prote
Externí odkaz:
https://doaj.org/article/046189b6ef98402f806f13d5a7619de7
Autor:
Megan E. Smithmyer, Alice E. Wiedeman, David A. G. Skibinski, Adam K. Savage, Carolina Acosta‐Vega, Sheila Scheiding, Vivian H. Gersuk, Colin O'Rourke, S. Alice Long, Jane H. Buckner, Cate Speake
Publikováno v:
Cytometry Part A. 101:351-360
Mislabeling samples or data with the wrong participant information can affect study integrity and lead investigators to draw inaccurate conclusions. Quality control to prevent these types of errors is commonly embedded into the analysis of genomic da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f7514fbf3c8220c91d9b6a7f55b1b0
https://doi.org/10.1002/cyto.a.24525
https://doi.org/10.1002/cyto.a.24525
Autor:
Claire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez, Morgan Weiss, Palak C. Genge, Julian Reading, Josephine R. Giles, Sasikanth Manne, Jeanette Dougherty, CJ Jasen, Allison R. Greenplate, Lynne A. Becker, Lucas T. Graybuck, Suhas V. Vasaikar, Gregory L. Szeto, Adam K. Savage, Cate Speake, Jane H. Buckner, Xiao-jun Li, Troy R. Torgerson, E. John Wherry, Thomas F. Bumol, Laura A. Vella, Sarah E. Henrickson, Peter J. Skene
The naive T cell compartment undergoes multiple changes across age that associate with altered susceptibility to infection and autoimmunity. In addition to the acquisition of naive-like memory T cell subsets, mouse studies describe substantial molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510ab66e66b266ad28cf5b58559c3b29
https://doi.org/10.1101/2022.10.04.510869
https://doi.org/10.1101/2022.10.04.510869
Autor:
Adam K. Savage, Carolina Acosta-Vega, Vivian H. Gersuk, Cate Speake, S. Alice Long, Megan E Smithmyer, Sheila Scheiding, David A. G. Skibinski, Jane H. Buckner, Alice E. Wiedeman
Mislabeling samples or data with the wrong participant information can impact study integrity and lead investigators to draw inaccurate conclusions. Quality control to prevent these types of errors is commonly embedded into the analysis of genomic da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12dd2179b2e1f9cd8afb4daf0ef8981
https://doi.org/10.1101/2021.10.26.465993
https://doi.org/10.1101/2021.10.26.465993
Autor:
Kelli C. Burley, Hamid Bolouri, Jeff Goldy, Paul Meijer, Peter J Skene, Ed Johnson, Thomas F. Bumol, Tanja Smith, Elliott Swanson, Cara Lord, Miriam V. Gutschow, Aldan Beaubien, Alexander T. Heubeck, Zachary Thomson, Ernest M. Coffey, Adam K. Savage, Xiao-jun Li, Monica Chaudhari, Jane H. Buckner, Tony Chiang, Palak C Genge, Nina Kondza, Kathy Henderson, Richard Green, Troy R. Torgerson
Publikováno v:
iScience
iScience, Vol 24, Iss 5, Pp 102404-(2021)
iScience, Vol 24, Iss 5, Pp 102404-(2021)
Summary Multi-omic profiling of human peripheral blood is increasingly utilized to identify biomarkers and pathophysiologic mechanisms of disease. The importance of these platforms in clinical and translational studies led us to investigate the impac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8178f77625edc469d4e3bb15c894f3b1
http://europepmc.org/articles/PMC8169801
http://europepmc.org/articles/PMC8169801
Autor:
Therese T. Cristal, Rodolfo Rios, Gerald Coulis, Adam K. Savage, Tahseen Mozaffar, Brandon S. Hughes, Scott Q. Harper, Jenna M. Kastenschmidt, Rachel E. Ayer, Archis A. Deshpande, S. Armando Villalta, Ali H. Mannaa, Richard M. Locksley, Rayan Yahia, Philip K. Farahat, Carlee R. Giesige, Phillip Pham
Publikováno v:
Cell reports, vol 35, iss 2
Cell reports
Cell Reports, Vol 35, Iss 2, Pp 108997-(2021)
Cell reports
Cell Reports, Vol 35, Iss 2, Pp 108997-(2021)
SUMMARY Despite the well-accepted view that chronic inflammation contributes to the pathogenesis of Duchenne muscular dystrophy (DMD), the function and regulation of eosinophils remain an unclear facet of type II innate immunity in dystrophic muscle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93634d2ee96482c107503c688e1e7242
https://escholarship.org/uc/item/57k699x2
https://escholarship.org/uc/item/57k699x2