Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Adam K. Rosenstein"'
Autor:
Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Publikováno v:
Nat Med
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =
Publikováno v:
Mucosal Immunology. 11:1558-1570
The emergence of biologic therapies is arguably the greatest therapeutic advance in the care of inflammatory bowel disease (IBD) to date, allowing directed treatments targeted at highly specific molecules shown to play critical roles in disease patho
Autor:
Mathieu Uzzan, Kamron Pourmand, Huaibin M. Ko, Saurabh Mehandru, Adam K. Rosenstein, Jean-Frederic Colombel
Publikováno v:
Annals of the New York Academy of Sciences. 1415:5-10
The vast majority of antibody-producing B cells are located within the gastrointestinal tract and are key players in maintaining homeostasis. The failure of rituximab, a potent B cell-depleting agent, to ameliorate ulcerative colitis in a single clin
Autor:
Jean-Frederic Colombel, Saurabh Mehandru, Marla Dubinsky, Mary E. Keir, Mathieu Uzzan, Ruiqi Huang, Shashibala Kumar, Francesca Petralia, Nandhini Ramamoorthi, Tomas Castro-Dopico, Sakteesh Gurunathan, Ephraim Kenigsberg, Adam K. Rosenstein, Mayte Suárez-Fariñas, Carmen Argmann, Gwendalyn J. Randolph, Menna R. Clatworthy, Benjamin L. Cohen, Adeeb Rahman, Akihiro Seki, Jerome Martin, Jason A. Hackney
Publikováno v:
Gastroenterology. 160:S-41
Autor:
Jerome Martin, R Huang, Carmen Argmann, Adeeb Rahman, Sakteesh Gurunathan, Menna R. Clatworthy, Adam K. Rosenstein, E Keningsberg, Marla Dubinsky, J.-F. Colombel, Benjamin L. Cohen, Ryan C. Ungaro, Tomas Castro-Dopico, Mayte Suárez-Fariñas, Saurabh Mehandru, Mathieu Uzzan
Publikováno v:
Journal of Crohn's and Colitis. 14:S181-S182
Background Among the adaptive immune cells, B cells, dominated by IgA producing plasma cells (PC), are critical for intestinal homeostasis. However, the B-cell response remains under studied in ulcerative colitis (UC). Methods Using single-cell RNA s
Publikováno v:
European journal of pharmacology. 850
Previous studies by us and others have indicated that berberine is a promising therapy for ulcerative colitis (UC). However, the mechanisms of UC and the therapeutic targets of berberine are poorly understood. iTRAQ-based proteomics was utilized to c
Autor:
Sakteesh Gurunathan, Jean-Frederic Colombel, Francesca Cossarini, Ruiqi Huang, Adam K. Rosenstein, Saurabh Mehandru, Akihiro Seki, Gwendalyn J. Randolph, Adeeb Rahman, Marla Dubinsky, Keshav Sharma, Mayte Suárez-Fariñas, Benjamin L. Cohen, Shashibala Kumar, Nandhini Ramamoorthi, Effi Kenigsberg, William O'Gorman, Ryan C. Ungaro, Tomas Castro-Dopico, Divya Jha, Mary E. Keir, Mathieu Uzzan, Francesca Petralia, Jerome Martin, Carmen Argmann, Menna R. Clatworthy, Jason A. Hackney
Publikováno v:
Gastroenterology. 158:S-116
Autor:
Hideki Ueno, Jennifer Lui, Akihiro Seki, Anupa Chokola, J.-F. Colombel, Timothy W. Schacker, Ivo N. SahBandar, Emma Kaplan-Lewis, Sergio A. Lira, Jean K. Lim, Louise Leyre, Itai Doron, Saurabh Mehandru, A. La Porte, Mathieu Uzzan, Bing Chen, Lishomwa C. Ndhlovu, Huaibin M. Ko, Nicolas Chomont, Glaucia C. Furtado, Eun-young Park, Amir Horowitz, Iliyan D. Iliev, Judith A. Aberg, Adam K. Rosenstein, Costin Tomescu, Ioannis Oikonomou, Michael J. Corley, Minami Tokuyama, Luis J. Montaner, Gabriela Rodriguez
Herein, we present the first human study of anti-α4β7 therapy in a cohort of HIV-1 infected subjects with mild inflammatory bowel disease. α4β7+ gut homing CD4+ T cells are early viral targets and contribute to HIV-1 pathogenesis, likely by seedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2656f902cb2e4b4f05531ead77803a24
Autor:
Luis J. Montaner, Saurabh Mehandru, Jean K. Lim, Gabriela Rodriguez, Iliyan D. Iliev, Louise Leyre, Eun-young Park, Adeeb Rahman, Hideki Ueno, Sergio A. Lira, Lishomwa C. Ndhlovu, Anupa Chokola, Amir Horowitz, Ivo N. SahBandar, Jennifer Lui, Akihiro Seki, Emma Kaplan-Lewis, Judith A. Aberg, Costin Tomescu, Benjamin K. Chen, Adam K. Rosenstein, Mathieu Uzzan, Annalena La Porte, Nicolas Chomont, Huaibin M. Ko, Minami Tokuyama, Glaucia C. Furtado, Jean-Frederic Colombel, Timothy W. Schacker, Itai Doron, Michael J. Corley, Ioannis Oikonomou
Publikováno v:
Science translational medicine. 10(461)
Gut homing CD4 + T cells expressing the integrin α4β7 are early viral targets and contribute to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although simianized anti-α4β7 monoclonal antibodies have shown promise
Autor:
Mathieu, Uzzan, Huaibin M, Ko, Adam K, Rosenstein, Kamron, Pourmand, Jean-Frederic, Colombel, Saurabh, Mehandru
Publikováno v:
Annals of the New York Academy of Sciences. 1415(1)
The vast majority of antibody-producing B cells are located within the gastrointestinal tract and are key players in maintaining homeostasis. The failure of rituximab, a potent B cell–depleting agent, to ameliorate ulcerative colitis in a single cl