Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Adam K. Hedger"'
Autor:
Atanu Maiti, Adam K. Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan K. Watts, Celia A. Schiffer, Hiroshi Matsuo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Here, the enzymatic activity of APOBEC3G resulting in conversion of 2′-deoxy-zebularine into a hydration product allowed the authors to capture the transition state, which provides a blueprint for designing a new class of transition state-mimicking
Externí odkaz:
https://doaj.org/article/9b59b40269cb4ef4b61dc593fa6d83f7
Autor:
Ashley N. Matthew, Jacqueto Zephyr, Desaboini Nageswara Rao, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam K. Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, includ
Externí odkaz:
https://doaj.org/article/c55fb866934b41dabb2b47c634a8609a
Publikováno v:
The Journal of Organic Chemistry. 88:5341-5347
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709b90c72ec0e3ea08691dfd119d0855
https://doi.org/10.1021/acs.joc.2c02861
https://doi.org/10.1021/acs.joc.2c02861
Pre-adenylated single-stranded DNA ligation adaptors are essential reagents in many next generation RNA sequencing library preparation protocols. These oligonucleotides can be adenylated enzymatically or chemically. Enzymatic adenylation reactions ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f59568d953e07d261ee172e7449dae89
https://doi.org/10.1101/2022.11.16.516815
https://doi.org/10.1101/2022.11.16.516815
Autor:
Nese Kurt Yilmaz, Desaboini Nageswara Rao, Hasahn L. Conway, Mohsan Saeed, Alicia Newton, Adam K. Hedger, Jacqueto Zephyr, Ashley N. Matthew, Akbar Ali, Mina Henes, Elise T Chan, Wei Huang, Christos J. Petropoulos, Celia A. Schiffer
Publikováno v:
J Med Chem
The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clinical use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5522535181ab0aabd2f1c0ce6ac851ee
https://doi.org/10.1021/acs.jmedchem.1c00554
https://doi.org/10.1021/acs.jmedchem.1c00554
Publikováno v:
RNA. :rna.079521.122
Pre-adenylated single-stranded DNA ligation adaptors are essential reagents in many next generation RNA sequencing library preparation protocols. These oligonucleotides can be adenylated enzymatically or chemically. Enzymatic adenylation reactions ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ebcbcba31cd250838a1d6fde1b5612d
https://doi.org/10.1261/rna.079521.122
https://doi.org/10.1261/rna.079521.122
Publikováno v:
Nature methods
Chromosome segregation requires both compaction and disentanglement of sister chromatids. We describe SisterC, a chromosome conformation capture assay that distinguishes interactions between and along identical sister chromatids. SisterC employs 5-br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a09e40875de45a23772255274ba2e21
https://doi.org/10.1038/s41592-020-0930-9
https://doi.org/10.1038/s41592-020-0930-9
Current chromosome conformation capture techniques are not able to distinguish sister chromatids. Here we describe the protocol of SisterC1: a novel Hi-C technique that leverages BrdU incorporation and UV/Hoechst-induced single strand breaks to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b33c469bd314c72dfbf50718755c1f84
https://doi.org/10.21203/rs.3.pex-1021/v1
https://doi.org/10.21203/rs.3.pex-1021/v1
Autor:
Adam K. Hedger, Wasih Kamran, Jennifer Timm, Akbar Ali, Desaboini Nageswara Rao, Nese Kurt Yilmaz, Gordon J. Lockbaum, Celia A. Schiffer, Klajdi Kosovrasti, Ashley N. Matthew, Jacqueto Zephyr, Mina Henes
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
mBio
mBio, Vol 11, Iss 2, p e00172-20 (2020)
mBio
mBio, Vol 11, Iss 2, p e00172-20 (2020)
Despite significant progress, hepatitis C virus (HCV) continues to be a major health problem with millions of people infected worldwide and thousands dying annually due to resulting complications. Recent antiviral combinations can achieve >95% cure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b19d2448aad70a5f22062b6047c4de3
https://doi.org/10.1128/mbio.00172-20
https://doi.org/10.1128/mbio.00172-20
Accurate chromosome segregation requires chromosome compaction with concordant disentanglement of the two sister chromatids. This process has been studied extensively by microscopy but has remained a challenge for genomic methods, such as Hi-C, becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d615ede7ac0f9829fb830c079f3ca468