Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Adam K A Wright"'
1
Akademický článek
Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung.
Autor: Adam K A Wright, Mathieu Bangert, Jenna F Gritzfeld, Daniela M Ferreira, Kondwani C Jambo, Angela D Wright, Andrea M Collins, Stephen B Gordon
Publikováno v: PLoS Pathogens, Vol 9, Iss 3, p e1003274 (2013)
Pneumococcal carriage is both immunising and a pre-requisite for mucosal and systemic disease. Murine models of pneumococcal colonisation show that IL-17A-secreting CD4(+) T-cells (Th-17 cells) are essential for clearance of pneumococci from the naso
Externí odkaz: https://doaj.org/article/991ee9a5e40343629520074aa869eb22
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2
Akademický článek
Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage.
Autor: Adam K A Wright, Daniela M Ferreira, Jenna F Gritzfeld, Angela D Wright, Kathryn Armitage, Kondwani C Jambo, Emily Bate, Sherouk El Batrawy, Andrea Collins, Stephen B Gordon
Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002622 (2012)
Infectious challenge of the human nasal mucosa elicits immune responses that determine the fate of the host-bacterial interaction; leading either to clearance, colonisation and/or disease. Persistent antigenic exposure from pneumococcal colonisation
Externí odkaz: https://doaj.org/article/66e905982c694e28a711f28005765625
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4
Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab
Autor: Koirobi Haldar, Adam K. A. Wright, Ubaldo J. Martin, Matthew Richardson, Mohammadali Yavari Ramsheh, Latifa Chachi, Amanda Sutcliffe, René van der Merwe, Leena George, Christopher E. Brightling, Paul Newbold, Vijay Mistry
Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease. 14:1177-1185
We hypothesized whether the reduction in eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) following treatment with benralizumab, a humanized, afucosylated, monoclonal antibody that binds to interleukin-5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aead4b3828f321e95c93c390b2937fb
https://doi.org/10.2147/copd.s198302
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5
The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes
Autor: Christof A. Leicht, Sven P. Hoekstra, Adam K. A. Wright, Nicolette C. Bishop
Publikováno v: Cell Stress & Chaperones
The acute inflammatory response to active or passive activities that increase body temperature may aid to reduce chronic low-grade inflammation. This study investigates the impact of temperature and extracellular heat shock protein 72 (eHsp72) on the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eabc563dbb43470eb122db63d8079d
http://europepmc.org/articles/PMC6439050
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7
Mepolizumab does not alter blood basophil count in severe asthma
Autor: Sarah Glover, Adam K. A. Wright, Dave Cousins, Michelle Bourne, Sarah Parker, Helen Evans, Liesl Carr, Salman Siddiqui, Marcia Soares, Sarah Edwards, Sarah Diver, Christopher E. Brightling, Jamie McCarthy, Andrew Marvin, Tracy Thornton, Michelle Craner
Publikováno v: Allergy and immunology.
Introduction: Mepolizumab (anti-human IL5) reduces blood eosinophils, however, it is less well known that blood basophils, also IL-5 receptor positive, are also decreased in routine clinical tests. Aims and Objectives: Our objective was to determine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0393947a6717db3fb63fbafa4a967536
https://doi.org/10.1183/13993003.congress-2019.pa4396
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9
Validation of antibodies for the specific detection of human TRPA1
Autor: Adam K. A. Wright, Latifa Chachi, Katy M. Roach, Peter Bradding, J. Sousa, Michael Biddle, Cathryn Weston, Harvinder Virk, M. Z. Rekas
Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
The transient receptor potential cation channel family member ankyrin 1 (TRPA1) is a potential target for several diseases, but detection of human TRPA1 (hTRPA1) protein in cells and tissues is problematic as rigorous antibody validation is lacking.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7227276209bc4fa5d5c76046735f9b8
https://pubmed.ncbi.nlm.nih.gov/31811235
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10
Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
Autor: Adam K. A. Wright, Sunil Gupta, Bethan Barker, Ruth Saunders, K. Edwards, Christopher E. Brightling, Tracy Thornton, M. Shelley, Ruth Hartley, Katy M. Roach, Vijay Mistry, Rachid Berair, Chris Newby
Publikováno v: Allergy. 72:645-655
The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease.Utilizing flow cytometry
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deb1d29c9abbda5a3aa90c39581ee91
https://doi.org/10.1111/all.13061
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