Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Adam Jochem"'
Autor:
Zachary A. Kemmerer, Kyle P. Robinson, Jonathan M. Schmitz, Mateusz Manicki, Brett R. Paulson, Adam Jochem, Paul D. Hutchins, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Coenzyme Q (CoQ) is a lipid made in the inner mitochondrial membrane with antioxidant roles throughout the cell, but regulation of its cellular distribution is unclear. Here the authors identify two proteins that have reciprocal CoQ trafficking funct
Externí odkaz:
https://doaj.org/article/0f3ed6133c854d93a8edf70a6550d460
Publikováno v:
eLife, Vol 10 (2021)
Copy number variation through gene or chromosome amplification provides a route for rapid phenotypic variation and supports the long-term evolution of gene functions. Although the evolutionary importance of copy-number variation is known, little is u
Externí odkaz:
https://doaj.org/article/60c4fbf3b4ee4f4b847914fd36d28baa
Autor:
Xiao Guo, Natalie M. Niemi, Paul D. Hutchins, Samson G.F. Condon, Adam Jochem, Arne Ulbrich, Alan J. Higbee, Jason D. Russell, Alessandro Senes, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 307-313 (2017)
Summary: Proper maintenance of mitochondrial activity is essential for metabolic homeostasis. Widespread phosphorylation of mitochondrial proteins may be an important element of this process; yet, little is known about which enzymes control mitochond
Externí odkaz:
https://doaj.org/article/b6c309bd7364473a84cfc593c6e3f2f0
Autor:
Jarred W. Rensvold, Evgenia Shishkova, Yuriy Sverchkov, Ian J. Miller, Arda Cetinkaya, Angela Pyle, Mateusz Manicki, Dain R. Brademan, Yasemin Alanay, Julian Raiman, Adam Jochem, Paul D. Hutchins, Sean R. Peters, Vanessa Linke, Katherine A. Overmyer, Austin Z. Salome, Alexander S. Hebert, Catherine E. Vincent, Nicholas W. Kwiecien, Matthew J. P. Rush, Michael S. Westphall, Mark Craven, Nurten A. Akarsu, Robert W. Taylor, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles(1) and have linked their dysfunction to more than 150 distinct disorders(2,
Autor:
Joshua J. Coon, Michael S. Westphall, Katherine A. Overmyer, David J. Pagliarini, Evgenia Shishkova, Edrees H. Rashan, Yuchen He, Alexander S. Hebert, Adam Jochem, Vanessa Linke
Publikováno v:
Anal Chem
Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and metabolome analysis. To have a better understanding of the multi-faceted networks of myriad regulatory layers in complex organisms, an integration on different la
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Copy number variation (CNV) through gene or chromosome amplification provides a route for rapid phenotypic variation and supports long-term evolution of gene functions. Although the evolutionary importance of CNV is known, little is understood about
Autor:
Maxence Le Vasseur, Thiruchelvi R. Reddy, Brett R. Paulson, Jason D. Russell, Adam Jochem, Samantha C. Lewis, David J. Pagliarini, Kelly Subramanian, Jodi Nunnari, Joshua J. Coon
Publikováno v:
The Journal of Cell Biology
CoQ lipids are built at the mitochondrial inner membrane by a multicomponent pathway. Subramanian et al. reveal that CoQ pathway components assemble via CoQ intermediates into domains at ER–mitochondria contacts, suggesting that CoQ domains functio
Autor:
Adam Jochem, Joshua J. Coon, Thiruchelvi R. Reddy, David J. Pagliarini, Jason D. Russell, Sheila E. Johnson, Kyle P. Robinson
Publikováno v:
J Biol Chem
Coenzyme Q (CoQ), a redox-active lipid essential for oxidative phosphorylation, is synthesized by virtually all cells, but how eukaryotes make the universal CoQ head group precursor 4-hydroxybenzoate (4-HB) from tyrosine is unknown. The first and las
Autor:
Jonathan M. Schmitz, Kyle P. Robinson, Joshua J. Coon, David J. Pagliarini, Zachary A. Kemmerer, Paul D. Hutchins, Brett Paulson, Adam Jochem
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid essential for many core metabolic processes in mitochondria, including oxidative phosphorylation1-3. While lesser appreciated, CoQ also serves as a key membrane-embedded antioxidant throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8416d82a16c7c58cc783f1fb15094ce0
https://doi.org/10.1101/2020.12.09.418202
https://doi.org/10.1101/2020.12.09.418202