Výsledky vyhledávání - "Adam Jeremiah Nagourney"

Abstract 4062: Activity of 3 Bromopyruvate in human tumor primary culture 3-dimensional explants using ex vivo analysis of programmed cell death

Autor: Adam Jeremiah Nagourney, Paulo D'Amora, Steven Scott Evans, Paula Bernard, Federico Francisco, Young Ko, Thomas Stockwell, Maxine Johnson, Robert Alan Nagourney

Publikováno v: Cancer Research. 82:4062-4062

Altered metabolism is a hallmark of human malignancy. The “Warburg Effect “reflecting increased glycolytic activity in the presence of oxygen represents an opportunity to target specific features of cancer to induce selective toxicity to malignan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12190ce32cd816915a0db95ace3d3643
https://doi.org/10.1158/1538-7445.am2022-4062

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Drugging the undruggable-targeting P53: A comparative analysis of APR-246 and coti-2 in human tumor primary culture explants

Autor: Adam Jeremiah Nagourney, Steven Scott Evans, Max Serge Duesberg, Paulo D'Amora, Paula J. Bernard, Eric Francisco, Robert Alan Nagourney

Publikováno v: Journal of Clinical Oncology. 40:e15092-e15092

e15092 Background: The TP53 tumor suppressor is the most commonly mutated gene in human cancer. P53 protein comprised of 393 amino acids functions as a tetramer with the loss of function mutations concentrated in “hotspots” that often affect DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c114c565ff00adae02b0445d4b70a97
https://doi.org/10.1200/jco.2022.40.16_suppl.e15092

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